scholarly journals ATP-Sensitive Potassium (KATP) Channel Openers Diazoxide and Nicorandil Lower Intraocular Pressure In Vivo

2013 ◽  
Vol 54 (7) ◽  
pp. 4892 ◽  
Author(s):  
Uttio Roy Chowdhury ◽  
Bradley H. Holman ◽  
Michael P. Fautsch
Keyword(s):  
Intraocular Pressure ◽  
Katp Channel ◽  
Katp Channel Openers

scholarly journals ATP-sensitive potassium (KATP) channel openers diazoxide and nicorandil lower intraocular pressure by activating the Erk1/2 signaling pathway

PLoS ONE ◽  
2017 ◽  
Vol 12 (6) ◽  
pp. e0179345 ◽  
Author(s):  
Uttio Roy Chowdhury ◽  
Cindy K. Bahler ◽  
Bradley H. Holman ◽  
Michael P. Fautsch
Keyword(s):  
Intraocular Pressure ◽  
Signaling Pathway ◽  
Katp Channel ◽  
Katp Channel Openers

Design, Synthesis and Biological Evaluation of Benzopyran Derivatives as KATP Channel Openers

2010 ◽  
Vol 7 (6) ◽  
pp. 415-420 ◽  
Author(s):  
Jinpei Zhou ◽  
Hai Qian ◽  
Huibin Zhang ◽  
Hui Gao ◽  
Wenlong Huang ◽  
...  
Keyword(s):  
Katp Channel ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation ◽  
Katp Channel Openers

scholarly journals Consequences of SUR2[A478V] Mutation in Skeletal Muscle of Murine Model of Cantu Syndrome

Cells ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 1791
Author(s):  
Rosa Scala ◽  
Fatima Maqoud ◽  
Nicola Zizzo ◽  
Giuseppe Passantino ◽  
Antonietta Mele ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Katp Channel ◽  
Ex Vivo ◽  
Channel Modulation ◽  
Flexor Digitorum Brevis ◽  
Inflammatory Edema ◽  
Flexor Digitorum ◽  
Channel Currents

(1) Background: Cantu syndrome (CS) arises from gain-of-function (GOF) mutations in the ABCC9 and KCNJ8 genes, which encode ATP-sensitive K+ (KATP) channel subunits SUR2 and Kir6.1, respectively. Most CS patients have mutations in SUR2, the major component of skeletal muscle KATP, but the consequences of SUR2 GOF in skeletal muscle are unknown. (2) Methods: We performed in vivo and ex vivo characterization of skeletal muscle in heterozygous SUR2[A478V] (SUR2wt/AV) and homozygous SUR2[A478V] (SUR2AV/AV) CS mice. (3) Results: In SUR2wt/AV and SUR2AV/AV mice, forelimb strength and diaphragm amplitude movement were reduced; muscle echodensity was enhanced. KATP channel currents recorded in Flexor digitorum brevis fibers showed reduced MgATP-sensitivity in SUR2wt/AV, dramatically so in SUR2AV/AV mice; IC50 for MgATP inhibition of KATP currents were 1.9 ± 0.5 × 10−5 M in SUR2wt/AV and 8.6 ± 0.4 × 10−6 M in WT mice and was not measurable in SUR2AV/AV. A slight rightward shift of sensitivity to inhibition by glibenclamide was detected in SUR2AV/AV mice. Histopathological and qPCR analysis revealed atrophy of soleus and tibialis anterior muscles and up-regulation of atrogin-1 and MuRF1 mRNA in CS mice. (4) Conclusions: SUR2[A478V] “knock-in” mutation in mice impairs KATP channel modulation by MgATP, markedly so in SUR2AV/AV, with atrophy and non-inflammatory edema in different skeletal muscle phenotypes.

KATP channel openers protect mesencephalic neurons against MPP+-induced cytotoxicity via inhibition of ROS production

2010 ◽  
Vol 88 (2) ◽  
pp. 428-437 ◽  
Author(s):  
Juan Xie ◽  
Lei Duan ◽  
Xia Qian ◽  
Xu Huang ◽  
Jianhua Ding ◽  
...  
Keyword(s):  
Katp Channel ◽  
Ros Production ◽  
Katp Channel Openers

Development of Novel Implantable Intraocular Pressure Sensors to Enhance the Performance in in vivo Tests

2015 ◽  
Vol 24 (6) ◽  
pp. 1896-1905 ◽  
Author(s):  
Kyeong-Sik Shin ◽  
Cheol-In Jang ◽  
Mi Jeung Kim ◽  
Kwang-Seok Yun ◽  
Ki Ho Park ◽  
...  
Keyword(s):  
Intraocular Pressure ◽  
Pressure Sensors ◽  
Intraocular Pressure Sensors

Structure–Activity studies for a novel series of tricyclic dihydropyrimidines as KATP channel openers (KCOs)

2002 ◽  
Vol 12 (11) ◽  
pp. 1481-1484 ◽  
Author(s):  
Irene Drizin ◽  
Mark W. Holladay ◽  
Lin Yi ◽  
Henry Q. Zhang ◽  
Sujatha Gopalakrishnan ◽  
...  
Keyword(s):  
Katp Channel ◽  
Structure Activity ◽  
Katp Channel Openers

scholarly journals Effect of Acute Increases in Intraocular Pressure on Corneal Pachymetry in Rabbit Eyes Treated with Timolol Maleate

2018 ◽  
Vol 12 (1) ◽  
pp. 314-321
Author(s):  
Cristina Sánchez-Barahona ◽  
Gema Bolívar ◽  
Dimitrios G. Mikropoulos ◽  
Anastasios G. Konstas ◽  
Miguel A. Teus
Keyword(s):  
Intraocular Pressure ◽  
Anterior Chamber ◽  
Central Corneal Thickness ◽  
Corneal Thickness ◽  
Rabbit Model ◽  
Controlled Study ◽  
Control Group ◽  
Study Group ◽  
Timolol Maleate

Objective: To evaluate in an in vivo rabbit model, the effect of topical timolol maleate therapy on the central corneal thickness response to acute intraocular pressure increases. Method: In this prospective and interventional controlled study, the central corneal thickness and intraocular pressure were measured in vivo in 12 rabbit eyes treated with topical timolol maleate for 1 month and in 12 controls at baseline, and after the intraocular pressure (measured by direct cannulation of the anterior chamber) was increased to 15 and 30 mmHg using a forced saline infusion into the anterior chamber. Results: There were no significant differences in the basal central corneal thickness values (control group, 373.2±12.9 µm; study group, 377.5±19.2 µm, p=0.5) or the central corneal thickness values when the intraocular pressure was increased to 15 mmHg (control group, 335.2±14.3 µm; study group, 330.0±32.1 µm, p=0.6) and to 30 mmHg (study group, 318.8±25.3 µm; control group, 329.8±21.0 µm, p=0.3). Conclusion: Rabbit corneas treated with topical timolol maleate for 1 month did not show a strain response to acute intraocular pressure increases that differed from control eyes. This is in contrast to a previous finding in which rabbit eyes treated with prostaglandin analogues had a greater decrease in central corneal thickness in response to a sudden intraocular pressure increase compared with untreated corneas.

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