scholarly journals Constriction of Retinal Arterioles to Endothelin-1: Requisite Role of Rho Kinase Independent of Protein Kinase C and L-Type Calcium Channels

2012 ◽  
Vol 53 (6) ◽  
pp. 2904 ◽  
Author(s):  
Luke B. Potts ◽  
Yi Ren ◽  
Guangrong Lu ◽  
Enoch Kuo ◽  
Ellen Ngo ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Calcium Channels ◽  
Rho Kinase ◽  
Endothelin 1 ◽  
Kinase C ◽  
Retinal Arterioles

Role of calcium channels and protein kinase C for release of norepinephrine and neuropeptide Y

1990 ◽  
Vol 259 (5) ◽  
pp. R925-R930
Author(s):  
M. Haass ◽  
C. Forster ◽  
G. Richardt ◽  
R. Kranzhofer ◽  
A. Schomig
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Calcium Channels ◽  
Calcium Channel ◽  
Neuropeptide Y ◽  
Nerve Fibers ◽  
Extracellular Calcium ◽  
Minor Effect ◽  
Kinase C

The role of calcium for the release of norepinephrine (NE, determined by high-pressure liquid chromatography) and neuropeptide Y (NPY, determined by radioimmunoassay) was investigated in guinea pig perfused hearts with intact sympathetic innervation. In the presence of extracellular calcium (1.85 mM), electrical stimulation of the left stellate ganglion (12 Hz, 1 min) induced a closely related release of NE and NPY with the molar ratio of approximately 400-600 (NE) to 1 (NPY). The stimulation-evoked overflow of both transmitters was dependent from the extracellular calcium concentration and was almost completely suppressed by calcium-free perfusion. The corelease of both transmitters was not affected by the L-type calcium channel blocker felodipine (1-10 microM). However, the overflow of NE and NPY was markedly attenuated by the unselective calcium antagonist flunarizine (1-10 microM) and completely prevented by the neuronal (N-type) calcium channel blockers omega-conotoxin (1-100 nM) and cadmium chloride (10-100 microM), indicating a key role for N-type calcium channels in the exocytotic release of transmitters from cardiac sympathetic nerve fibers. Possibly due to unspecific actions, such as interference with sodium channels or uptake1-blocking properties, the phenylalkylamines verapamil (0.01-10 microM) and gallopamil (1-10 microM) reduced NPY overflow with only a minor effect on NE overflow. The stimulation-induced transmitter release was increased up to twofold by activation of protein kinase C (phorbol 12-myristate 13-acetate, 3 nM-3 microM) and completely suppressed by inhibition of protein kinase C (polymyxin B, 100 microM).(ABSTRACT TRUNCATED AT 250 WORDS)

Interactive Role of Protein Kinase C-δ with Rho-Kinase in the Development of Cerebral Vasospasm in a Canine Two-Hemorrhage Model

2005 ◽  
Vol 42 (1) ◽  
pp. 67-76 ◽  
Author(s):  
Kazuo Obara ◽  
Shigeru Nishizawa ◽  
Masayo Koide ◽  
Kayo Nozawa ◽  
Ayako Mitate ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Cerebral Vasospasm ◽  
Rho Kinase ◽  
Kinase C

scholarly journals Exaggerated coronary vasoreactivity to endothelin-1 in aged rats: Role of protein kinase C

2005 ◽  
Vol 66 (2) ◽  
pp. 384-392 ◽  
Author(s):  
D KORZICK ◽  
J MULLERDELP ◽  
P DOUGHERTY ◽  
C HEAPS ◽  
D BOWLES ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Aged Rats ◽  
Endothelin 1 ◽  
Kinase C
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