scholarly journals Depletion ofSLC4A11Causes Cell Death by Apoptosis in an Immortalized Human Corneal Endothelial Cell Line

2012 ◽  
Vol 53 (7) ◽  
pp. 3270 ◽  
Author(s):  
Jun Liu ◽  
Li-Fong Seet ◽  
Li Wei Koh ◽  
Anandalakshmi Venkatraman ◽  
Divya Venkataraman ◽  
...  
Keyword(s):  
Cell Death ◽  
Endothelial Cell ◽  
Cell Line ◽  
Corneal Endothelial Cell ◽  
Endothelial Cell Line

Effects of Phthalates on the Human Corneal Endothelial Cell Line B4G12

2012 ◽  
Vol 31 (4) ◽  
pp. 364-371 ◽  
Author(s):  
Tanja Krüger ◽  
Yi Cao ◽  
Søren K. Kjærgaard ◽  
Lisbeth E. Knudsen ◽  
Eva C. Bonefeld-Jørgensen
Keyword(s):  
Gene Expression ◽  
Cell Proliferation ◽  
Endothelial Cell ◽  
Cell Line ◽  
Corneal Endothelial Cell ◽  
Industrial Chemicals ◽  
Cell Secretion ◽  
Endothelial Cell Line ◽  
Butyl Phthalate

Phthalates are industrial chemicals used in many cosmetics. We evaluated an in vitro model for eye irritancy testing using the human corneal endothelial cell line B4G12. Cell proliferation and toxicity were assessed after exposing to di- n-butyl phthalate (DBP), benzyl butyl phthalate (BBP), di-2-ethylhexyl phthalate (DEHP), diisodecyl phthalate (DIDP), di- n-octyl phthalate (DnOP), and di-isononyl phthalate (DINP). Gene expression and secretion of inflammatory cytokines were evaluated after exposure to DBP. Decreased cell proliferation was observed for the phthalates DBP, BBP, and DEHP, and cell toxicity was observed for DBP and BBP. Upon DBP exposure at nontoxic concentrations, a significant increased gene expression and cytokine cell secretion were observed for interleukin-1β (IL-1β) and IL-8, and also an increased IL-6 secretion was observed. In conclusion, the human corneal endothelial cell line B4G12 may be a potential model for inflammatory eye irritancy testing of phthalates.

Development and Characterization of a Rabbit Corneal Endothelial Cell Line

2004 ◽  
Vol 48 (5) ◽  
pp. 454-459 ◽  
Author(s):  
Jun Seop Shin ◽  
In Keun Jang ◽  
Chan Wha Kim ◽  
Jae Chan Kim
Keyword(s):  
Endothelial Cell ◽  
Cell Line ◽  
Corneal Endothelial Cell ◽  
Endothelial Cell Line

Establishment of a novel corneal endothelial cell line from domestic rabbit, Oryctolagus curiculus

2007 ◽  
Vol 50 (2) ◽  
pp. 161-169 ◽  
Author(s):  
TingJun Fan ◽  
Jun Zhao ◽  
YongFeng Fu ◽  
RiShan Cong ◽  
RuiChao Guo ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Cell Line ◽  
Corneal Endothelial Cell ◽  
Endothelial Cell Line ◽  
Domestic Rabbit

scholarly journals Establishment of Functioning Human Corneal Endothelial Cell Line with High Growth Potential

PLoS ONE ◽  
2012 ◽  
Vol 7 (1) ◽  
pp. e29677 ◽  
Author(s):  
Tadashi Yokoi ◽  
Yuko Seko ◽  
Tae Yokoi ◽  
Hatsune Makino ◽  
Shin Hatou ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Cell Line ◽  
High Growth ◽  
Corneal Endothelial Cell ◽  
Growth Potential ◽  
Endothelial Cell Line ◽  
High Growth Potential
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