Morphometric Characteristics of Central Retinal Artery and Vein Endothelium in the Normal Human Optic Nerve Head

2011 ◽  
Vol 52 (3) ◽  
pp. 1359 ◽  
Author(s):  
Min H. Kang ◽  
Chandrakumar Balaratnasingam ◽  
Paula K. Yu ◽  
William H. Morgan ◽  
Ian L. McAllister ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Optic Nerve Head ◽  
Central Retinal Artery ◽  
Morphometric Characteristics ◽  
Normal Human ◽  
Retinal Artery ◽  
Human Optic Nerve

Age-Related Topographical Changes in the Normal Human Optic Nerve Head Measured by Scanning Laser Tomography

2001 ◽  
Vol 78 (6) ◽  
pp. 431-435 ◽  
Author(s):  
HÉLÈNE KERGOAT ◽  
MARIE-JEANNE KERGOAT ◽  
LISETTE JUSTINO ◽  
and JOHN V. LOVASIK
Keyword(s):  
Optic Nerve ◽  
Optic Nerve Head ◽  
Scanning Laser ◽  
Laser Tomography ◽  
Age Related ◽  
Normal Human ◽  
Human Optic Nerve

Association of systemic cardio-vasculature status with retinal vascular endothelium in diabetes

2020 ◽  
Vol 1 (1) ◽  
pp. 52-57
Author(s):  
Galina Dimitrova ◽  
Keyword(s):  
Blood Flow ◽  
Diabetic Retinopathy ◽  
Optic Nerve ◽  
Arterial Stiffness ◽  
Vascular Endothelium ◽  
Lamina Cribrosa ◽  
Central Retinal Artery ◽  
Diabetic Patients ◽  
Retinal Artery ◽  
Central Retinal Vein

The relationship between diabetic retinopathy and macro-vascular complications in diabetes suggests a pathogenic association between these conditions. Vascular endothelium has been identified as a main site of blood vessel injury in diabetes. Diabetic retinopathy is associated with systemic arterial stiffness and altered vascular endothelium function and structure. Retinal vasculature endothelium at the macula, arterio-venous crossings, and in the optic nerve at the lamina cribrosa region is reported to differ from the endothelium in the rest of the retinal blood vessels. The central retinal artery and vein are in close proximity in the optic nerve where they share a common adventitia; thus, increased arterial wall stiffness and thickness may affect blood flow in the neighboring central retinal vein in this region. Moreover, increased arterial stiffness in small arterial beds is associated with retinal venular widening; it suggests the possibility of central retinal artery compressing the central retinal vein at the lamina cribrosa, thereby compromising venular outflow in the retina of diabetic patients. Altered blood flow in the central retinal vein in the postlaminar region has been detected in patients who experience progression of diabetic retinopathy. Increased hydrostatic pressure in the central retinal vein may play a major role in the pathogenesis of diabetic retinopathy. The aim of this review article is to emphasize this pathogenetic mechanism that has often been overlooked.

scholarly journals Microvascular Density Is Associated With Retinal Ganglion Cell Axonal Volume in the Laminar Compartments of the Human Optic Nerve Head

2018 ◽  
Vol 59 (3) ◽  
pp. 1562 ◽  
Author(s):  
Min H. Kang ◽  
Mengchen Suo ◽  
Chandrakumar Balaratnasingam ◽  
Paula K. Yu ◽  
William H. Morgan ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Optic Nerve Head ◽  
Microvascular Density ◽  
Retinal Ganglion ◽  
Human Optic Nerve

Sonographic assessment of the optic nerve and the central retinal artery in idiopathic intracranial hypertension

2020 ◽  
Vol 72 ◽  
pp. 292-297 ◽  
Author(s):  
Monika Jeub ◽  
Elena Schlapakow ◽  
Martina Ratz ◽  
Christine Kindler ◽  
Arndt-Hendrik Schievelkamp ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Intracranial Hypertension ◽  
Idiopathic Intracranial Hypertension ◽  
Central Retinal Artery ◽  
Sonographic Assessment ◽  
Retinal Artery

Variations in the Blood Flow of the Human Optic Nerve Head

1997 ◽  
Vol 7 (4) ◽  
pp. 364-369 ◽  
Author(s):  
R. Osuský ◽  
A. Schoetzau ◽  
J. Flammer
Keyword(s):  
Blood Flow ◽  
Optic Nerve ◽  
Optic Nerve Head ◽  
Continuous Measurement ◽  
The Body ◽  
Flow Volume ◽  
Frequency Range ◽  
Flow Fluctuations ◽  
Human Optic Nerve ◽  
Doppler Flowmeter

Blood flow in various tissues of the body shows spontaneous variations. The purpose of this study was to analyze variations over time in the blood flow of the optic nerve head. Blood flow was measured by the laser Doppler flowmeter (LDF) in 12 healthy volunteers, and analyzed by spectral Fourier analysis. The LDF technique allows continuous measurement of flow, volume, and velocity in the microcirculation of the optic nerve head. We found variations expressed in cycles per minute (c/min) at frequencies characteristic of vasomotion (<10 c/min) of breathing, and of cardiac pulsation. Oscillations at frequency <10 c/min predominated in volume in all subjects and in flow in all but one. Variations in velocity of 60-90 c/min were identified in 10 of the 12 volunters. Oscillations in the range of breathing frequency made the smallest contribution to changes in blood flow. Fluctuations in the frequency range of 5 c/min and lower were observed most frequently, and the majority of subjects showed fluctuations of several frequencies. Our results provide evidence that blood flow in the human optic nerve head presents some characteristics already known from the general physiology of the microcirculation.

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