scholarly journals Microvascular Density Is Associated With Retinal Ganglion Cell Axonal Volume in the Laminar Compartments of the Human Optic Nerve Head

2018 ◽  
Vol 59 (3) ◽  
pp. 1562 ◽  
Author(s):  
Min H. Kang ◽  
Mengchen Suo ◽  
Chandrakumar Balaratnasingam ◽  
Paula K. Yu ◽  
William H. Morgan ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Optic Nerve Head ◽  
Microvascular Density ◽  
Retinal Ganglion ◽  
Human Optic Nerve

scholarly journals OPTICAL COHERENCE TOMOGRAPHY

2016 ◽  
Vol 23 (09) ◽  
pp. 1149-1156
Author(s):  
Faheem Ahmad ◽  
Muhmmad Hussian
Keyword(s):  
Optic Nerve ◽  
Diagnostic Accuracy ◽  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Optic Nerve Head ◽  
Predictive Value ◽  
Structural Changes ◽  
Retinal Ganglion ◽  
Fiber Layer ◽  
Cross Sectional

“Glaucoma an optic neuropathy is a caused by progressive retinal ganglion cell(RGC) loss associated with characteristic structural changes in the optic nerve and retinal nervefiber layer (RNFL).Glaucoma induced damage causes the retinal ganglion cells loss that canresult in functional loss and decrease in vision of patient . Measurement of intraocular pressureby Tonometery, characteristics of the optic nerve head changes and associated visual fieldloss are used for diagnosis of Glaucoma. Objectives: To determine the diagnostic accuracy ofOptical Coherence Tomography in detection of glaucoma taking perimetry as gold standard.Study Design: Cross sectional (validation). Period: Six months from 17-02-2014 to 16-08-2014.Material and Method: Regarding the Inclusion Criteria patients of glaucoma suspects that meetthe criteria mentioned in operational definition of either gender with age range between 35- 60years were included while patients having refractive errors, hazy media, pupil size less than4mm after dilation were not included in this study. Also patients with history diabetes mellitus,refractive or retinal surgery were also excluded. All the data was entered and analyzed by usingSPSS V-16. Results: A total of 100 patients were included in this study during the study period.Majority of the patients were between 35-45 years of age and minimum patients were 56-60 years old. Mean age of the patients was 47.10±8.02 years. Males and females were 50(50%). At OCT glaucoma was present in 71 patients while at perimetry glaucoma was presentin 69 patients .Sensitivity, specificity and diagnostic accuracy of OCT was 92.7%, 77.4%, 88.0%,respectively .Positive predictive value and negative predictive value of OCT was 90.1% and82.7%, respectively. Discussion: Regarding the pathogenesis of Glaucoma induced damageis due to result of retinal ganglion cell (RGC) death with progressive loss of axons located inthe retinal nerve fiber layer (RNFL). Many clinical studies showed that optic nerve head (ONH)damage and thinning of the RNFL occur earlier than the appearance of Glaucoma inducedvisual field defects; Conclusion: In conclusion, glaucoma suspects undergoing the OCT canbe assessed for the presence of glaucoma based purely on the results of the OCT.

scholarly journals Translational profiling of retinal ganglion cell optic nerve regeneration in Xenopus laevis

2017 ◽  
Vol 426 (2) ◽  
pp. 360-373 ◽  
Author(s):  
G.B. Whitworth ◽  
B.C. Misaghi ◽  
D.M. Rosenthal ◽  
E.A. Mills ◽  
D.J. Heinen ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Xenopus Laevis ◽  
Ganglion Cell ◽  
Nerve Regeneration ◽  
Retinal Ganglion Cell ◽  
Retinal Ganglion ◽  
Optic Nerve Regeneration

Different functional susceptibilities of mouse retinal ganglion cell subtypes to optic nerve crush injury

2017 ◽  
Vol 162 ◽  
pp. 97-103 ◽  
Author(s):  
Zhen Puyang ◽  
Hai-Qing Gong ◽  
Shi-Gang He ◽  
John B. Troy ◽  
Xiaorong Liu ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Crush Injury ◽  
Optic Nerve Crush ◽  
Retinal Ganglion ◽  
Nerve Crush ◽  
Nerve Crush Injury

Long-Term Effect of Optic Nerve Axotomy on the Retinal Ganglion Cell Layer

2015 ◽  
Vol 56 (10) ◽  
pp. 6095 ◽  
Author(s):  
Francisco M. Nadal-Nicolás ◽  
Paloma Sobrado-Calvo ◽  
Manuel Jiménez-López ◽  
Manuel Vidal-Sanz ◽  
Marta Agudo-Barriuso
Keyword(s):  
Optic Nerve ◽  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Ganglion Cell Layer ◽  
Cell Layer ◽  
Term Effect ◽  
Retinal Ganglion ◽  
Long Term Effect ◽  
Retinal Ganglion Cell Layer

scholarly journals Exosome-Mediated Delivery of the Neuroprotective Peptide PACAP38 Promotes Retinal Ganglion Cell Survival and Axon Regeneration in Rats With Traumatic Optic Neuropathy

2021 ◽  
Vol 9 ◽  
Author(s):  
Tian Wang ◽  
Yiming Li ◽  
Miao Guo ◽  
Xue Dong ◽  
Mengyu Liao ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Optic Neuropathy ◽  
Axon Regeneration ◽  
Retinal Ganglion ◽  
Traumatic Optic Neuropathy ◽  
Fiber Layer

Traumatic optic neuropathy (TON) refers to optic nerve damage caused by trauma, leading to partial or complete loss of vision. The primary treatment options, such as hormonal therapy and surgery, have limited efficacy. Pituitary adenylate cyclase-activating polypeptide 38 (PACAP38), a functional endogenous neuroprotective peptide, has emerged as a promising therapeutic agent. In this study, we used rat retinal ganglion cell (RGC) exosomes as nanosized vesicles for the delivery of PACAP38 loaded via the exosomal anchor peptide CP05 (EXOPACAP38). EXOPACAP38 showed greater uptake efficiency in vitro and in vivo than PACAP38. The results showed that EXOPACAP38 significantly enhanced the RGC survival rate and retinal nerve fiber layer thickness in a rat TON model. Moreover, EXOPACAP38 significantly promoted axon regeneration and optic nerve function after injury. These findings indicate that EXOPACAP38 can be used as a treatment option and may have therapeutic implications for patients with TON.

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