In Vivo Imaging of Retinal Ganglion Cell Axons within the Nerve Fiber Layer

2010 ◽  
Vol 51 (4) ◽  
pp. 2011 ◽  
Author(s):  
Akiyasu Kanamori ◽  
Maria-Magdalena Catrinescu ◽  
Manuela Traistaru ◽  
Rachel Beaubien ◽  
Leonard A. Levin
Keyword(s):  
Ganglion Cell ◽  
Nerve Fiber ◽  
Retinal Ganglion Cell ◽  
In Vivo Imaging ◽  
Retinal Ganglion ◽  
Fiber Layer ◽  
Nerve Fiber Layer

scholarly journals Nerve Fiber Layer Thinning Lags Retinal Ganglion Cell Density Following Crush Axonopathy

2014 ◽  
Vol 55 (10) ◽  
pp. 6505 ◽  
Author(s):  
Gustavo C. Munguba ◽  
Sanja Galeb ◽  
Yuan Liu ◽  
David C. Landy ◽  
Daisy Lam ◽  
...  
Keyword(s):  
Ganglion Cell ◽  
Nerve Fiber ◽  
Cell Density ◽  
Retinal Ganglion Cell ◽  
Retinal Ganglion ◽  
Fiber Layer ◽  
Nerve Fiber Layer

scholarly journals Estimated Retinal Ganglion Cell Counts in Glaucomatous Eyes with Localized Retinal Nerve Fiber Layer Defects

2013 ◽  
Vol 156 (3) ◽  
pp. 578-587.e1 ◽  
Author(s):  
Andrew J. Tatham ◽  
Robert N. Weinreb ◽  
Linda M. Zangwill ◽  
Jeffrey M. Liebmann ◽  
Christopher A. Girkin ◽  
...  
Keyword(s):  
Ganglion Cell ◽  
Nerve Fiber ◽  
Retinal Ganglion Cell ◽  
Retinal Nerve Fiber Layer ◽  
Retinal Ganglion ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Cell Counts ◽  
Retinal Nerve Fiber

scholarly journals Retinal Ganglion Cell Layer Thinning Followed By Retinal Nerve Fiber Layer Thinning In Patients with Uveitis

2016 ◽  
Vol 1 (2) ◽  
Keyword(s):  
Optic Nerve ◽  
Ganglion Cell ◽  
Nerve Fiber ◽  
Retinal Ganglion Cell ◽  
Ganglion Cell Layer ◽  
Cell Layer ◽  
Retinal Ganglion ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Retinal Ganglion Cell Layer

In the model of experimentally induced ischemia- reperfusion injury, retinal ganglion cells (RGC) expressing the gene AP-1 result apoptosis. The inflammation mediators, such as TNF-α, IL-1β, etc. lead RGC to apoptosis, that may lead the thinning of the retinal ganglion cell layer (RGCL) followed by the optic nerve fiber layer (RNFL) thinning. In his study we observed retinal ganglion cell and optic nerve fiber layer thinning in patients with various uveitis, that the pathological features appear obliterative vasculitis, using the optical coherence tomography (OCT) imaging analyses. Subjects were 182 eyes of 91 uveitis patients without glaucoma. Comparison were patients with normal tension glaucoma (NTG). Image analyses were conducted with 3D OCT-2000. As a result average RGCL thickness values in the patients with uveitis were significantly(p<0.01) thinner than those in healthies. Cycle scan findings of RNFL around the optic disc in the patients with uveitis showed significant thinning especially at nasal side. The retinal ganglion cell layer thinning followed by the retinal nerve fiber thinning in the patients with various uveitis was observed, and the thinning was similar to that in patients with glaucoma. The observation of RGCL and RNFL thickness may be useful for the diagnosis and the follow-up of uveitis.

scholarly journals Tissue engineering the retinal ganglion cell nerve fiber layer

Biomaterials ◽  
2013 ◽  
Vol 34 (17) ◽  
pp. 4242-4250 ◽  
Author(s):  
Karl E. Kador ◽  
Ramon B. Montero ◽  
Praseeda Venugopalan ◽  
Jonathan Hertz ◽  
Allison N. Zindell ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Ganglion Cell ◽  
Nerve Fiber ◽  
Retinal Ganglion Cell ◽  
Retinal Ganglion ◽  
Fiber Layer ◽  
Nerve Fiber Layer

scholarly journals In-vivo imaging of retinal nerve fiber layer vasculature: imaging - histology comparison

2009 ◽  
Vol 9 (1) ◽  
Author(s):  
Drew Scoles ◽  
Daniel C Gray ◽  
Jennifer J Hunter ◽  
Robert Wolfe ◽  
Bernard P Gee ◽  
...  
Keyword(s):  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
In Vivo Imaging ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Retinal Nerve Fiber

scholarly journals Exosome-Mediated Delivery of the Neuroprotective Peptide PACAP38 Promotes Retinal Ganglion Cell Survival and Axon Regeneration in Rats With Traumatic Optic Neuropathy

2021 ◽  
Vol 9 ◽  
Author(s):  
Tian Wang ◽  
Yiming Li ◽  
Miao Guo ◽  
Xue Dong ◽  
Mengyu Liao ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Optic Neuropathy ◽  
Axon Regeneration ◽  
Retinal Ganglion ◽  
Traumatic Optic Neuropathy ◽  
Fiber Layer

Traumatic optic neuropathy (TON) refers to optic nerve damage caused by trauma, leading to partial or complete loss of vision. The primary treatment options, such as hormonal therapy and surgery, have limited efficacy. Pituitary adenylate cyclase-activating polypeptide 38 (PACAP38), a functional endogenous neuroprotective peptide, has emerged as a promising therapeutic agent. In this study, we used rat retinal ganglion cell (RGC) exosomes as nanosized vesicles for the delivery of PACAP38 loaded via the exosomal anchor peptide CP05 (EXOPACAP38). EXOPACAP38 showed greater uptake efficiency in vitro and in vivo than PACAP38. The results showed that EXOPACAP38 significantly enhanced the RGC survival rate and retinal nerve fiber layer thickness in a rat TON model. Moreover, EXOPACAP38 significantly promoted axon regeneration and optic nerve function after injury. These findings indicate that EXOPACAP38 can be used as a treatment option and may have therapeutic implications for patients with TON.

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