Crucial Role of Apoptosis in the Resolution of Experimental Autoimmune Anterior Uveitis

2007 ◽  
Vol 48 (11) ◽  
pp. 5091 ◽  
Author(s):  
Purushottam Jha ◽  
Bharati Matta ◽  
Valeriy Lyzogubov ◽  
Ruslana Tytarenko ◽  
Puran S. Bora ◽  
...  
Keyword(s):  
Anterior Uveitis ◽  
Crucial Role ◽  
Experimental Autoimmune Anterior Uveitis ◽  
Experimental Autoimmune

Crucial role of P2X7 receptor for effector T cell activation in experimental autoimmune uveitis

2018 ◽  
Vol 62 (3) ◽  
pp. 398-406 ◽  
Author(s):  
Atsunobu Takeda ◽  
Hisakata Yamada ◽  
Eiichi Hasegawa ◽  
Mitsuru Arima ◽  
Shoji Notomi ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Activation ◽  
Crucial Role ◽  
P2x7 Receptor ◽  
Cell Activation ◽  
Experimental Autoimmune Uveitis ◽  
Autoimmune Uveitis ◽  
Effector T Cell ◽  
Experimental Autoimmune

Immunohistochemical studies on melanin associated antigen (MAA) induced experimental autoimmune anterior uveitis (EAAU)

1995 ◽  
Vol 14 (8) ◽  
pp. 703-710 ◽  
Author(s):  
Mike C. Kim ◽  
Nisreen H. Kabeer ◽  
Michael T. Tandhasetti ◽  
Henry J. Kaplan ◽  
Nalini S. Bora
Keyword(s):  
Anterior Uveitis ◽  
Experimental Autoimmune Anterior Uveitis ◽  
Immunohistochemical Studies ◽  
Experimental Autoimmune

Expressions of lymphotactin and its receptor, XCR, in Lewis rats with experimental autoimmune anterior uveitis

2010 ◽  
Vol 248 (12) ◽  
pp. 1737-1747 ◽  
Author(s):  
Po-Ting Yeh ◽  
Feng-An Lin ◽  
Chang-Pin Lin ◽  
Chung-May Yang ◽  
Muh-Shy Chen ◽  
...  
Keyword(s):  
Anterior Uveitis ◽  
Lewis Rats ◽  
Experimental Autoimmune Anterior Uveitis ◽  
Experimental Autoimmune

scholarly journals Chitosan Oligosaccharides Attenuate Ocular Inflammation in Rats with Experimental Autoimmune Anterior Uveitis

2014 ◽  
Vol 2014 ◽  
pp. 1-15 ◽  
Author(s):  
I-Mo Fang ◽  
Chang-Hao Yang ◽  
Chung-May Yang
Keyword(s):  
Inflammatory Mediators ◽  
Anterior Uveitis ◽  
Culture Media ◽  
High Dose ◽  
Dependent Manner ◽  
Protective Effects ◽  
Chitosan Oligosaccharides ◽  
Clinical Scores ◽  
Experimental Autoimmune Anterior Uveitis ◽  
Experimental Autoimmune

We investigated the protective effects and mechanisms of chitosan oligosaccharides (COS) on experimental autoimmune anterior uveitis (EAAU) in rats. EAAU was induced in Lewis rats by footpad and intraperitoneal injections of melanin-associated antigen. The rats received intraperitoneal injections of low-dose (5 mg/kg) or high-dose (10 mg/kg) COS or PBS daily after the immunization. The effects of COS were evaluated by determining the clinical scores and the morphology of the iris/ciliary body (ICB). The expression of inflammatory mediators was evaluated using western blot, immunofluorescence, and ELISA. Treatment with COS significantly attenuated the clinical scores and the leukocyte infiltration in the ICB in a dose-dependent manner. COS effectively reduced the expression of inflammatory mediators (TNF-α, iNOS, MCP-1, RANTES, fractalkine, and ICAM-1). Moreover, COS decreased the IκB degradation and p65 presence in the ICB, which resulted in the inhibition of NF-κB/DNA binding activity. In an in vitro study, sensitized spleen-derived lymphocytes of the COS-treated group showed less chemotaxis toward their aqueous humor and decreased secretion of the above inflammatory mediators in the culture media. COS treated EAAU by inhibiting the activation of NF-κB and reducing the expression of inflammatory mediators. COS might be a potential treatment for acute anterior uveitis.

Crucial Role of Interferon-γ in Experimental Autoimmune Prostatitis

2010 ◽  
Vol 183 (3) ◽  
pp. 1213-1220 ◽  
Author(s):  
Ruben Darío Motrich ◽  
Evelyne van Etten ◽  
Femke Baeke ◽  
Clelia Maria Riera ◽  
Chantal Mathieu ◽  
...  
Keyword(s):  
Crucial Role ◽  
Interferon Γ ◽  
Experimental Autoimmune

scholarly journals Type I Collagen Is the Autoantigen in Experimental Autoimmune Anterior Uveitis

2004 ◽  
Vol 172 (11) ◽  
pp. 7086-7094 ◽  
Author(s):  
Nalini S. Bora ◽  
Jeong-Hyeon Sohn ◽  
Shin-Goo Kang ◽  
Jose M. C. Cruz ◽  
Hiroki Nishihori ◽  
...  
Keyword(s):  
Anterior Uveitis ◽  
Type I Collagen ◽  
Type I ◽  
Experimental Autoimmune Anterior Uveitis ◽  
Experimental Autoimmune
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