scholarly journals The Complement System Plays a Critical Role in the Development of Experimental Autoimmune Anterior Uveitis

2006 ◽  
Vol 47 (3) ◽  
pp. 1030 ◽  
Author(s):  
Purushottam Jha ◽  
Jeong-Hyeon Sohn ◽  
Qin Xu ◽  
Hiroki Nishihori ◽  
Yali Wang ◽  
...  
Keyword(s):  
Complement System ◽  
Anterior Uveitis ◽  
Critical Role ◽  
Experimental Autoimmune Anterior Uveitis ◽  
The Complement System ◽  
Experimental Autoimmune

Immunohistochemical studies on melanin associated antigen (MAA) induced experimental autoimmune anterior uveitis (EAAU)

1995 ◽  
Vol 14 (8) ◽  
pp. 703-710 ◽  
Author(s):  
Mike C. Kim ◽  
Nisreen H. Kabeer ◽  
Michael T. Tandhasetti ◽  
Henry J. Kaplan ◽  
Nalini S. Bora
Keyword(s):  
Anterior Uveitis ◽  
Experimental Autoimmune Anterior Uveitis ◽  
Immunohistochemical Studies ◽  
Experimental Autoimmune

Expressions of lymphotactin and its receptor, XCR, in Lewis rats with experimental autoimmune anterior uveitis

2010 ◽  
Vol 248 (12) ◽  
pp. 1737-1747 ◽  
Author(s):  
Po-Ting Yeh ◽  
Feng-An Lin ◽  
Chang-Pin Lin ◽  
Chung-May Yang ◽  
Muh-Shy Chen ◽  
...  
Keyword(s):  
Anterior Uveitis ◽  
Lewis Rats ◽  
Experimental Autoimmune Anterior Uveitis ◽  
Experimental Autoimmune

scholarly journals Chitosan Oligosaccharides Attenuate Ocular Inflammation in Rats with Experimental Autoimmune Anterior Uveitis

2014 ◽  
Vol 2014 ◽  
pp. 1-15 ◽  
Author(s):  
I-Mo Fang ◽  
Chang-Hao Yang ◽  
Chung-May Yang
Keyword(s):  
Inflammatory Mediators ◽  
Anterior Uveitis ◽  
Culture Media ◽  
High Dose ◽  
Dependent Manner ◽  
Protective Effects ◽  
Chitosan Oligosaccharides ◽  
Clinical Scores ◽  
Experimental Autoimmune Anterior Uveitis ◽  
Experimental Autoimmune

We investigated the protective effects and mechanisms of chitosan oligosaccharides (COS) on experimental autoimmune anterior uveitis (EAAU) in rats. EAAU was induced in Lewis rats by footpad and intraperitoneal injections of melanin-associated antigen. The rats received intraperitoneal injections of low-dose (5 mg/kg) or high-dose (10 mg/kg) COS or PBS daily after the immunization. The effects of COS were evaluated by determining the clinical scores and the morphology of the iris/ciliary body (ICB). The expression of inflammatory mediators was evaluated using western blot, immunofluorescence, and ELISA. Treatment with COS significantly attenuated the clinical scores and the leukocyte infiltration in the ICB in a dose-dependent manner. COS effectively reduced the expression of inflammatory mediators (TNF-α, iNOS, MCP-1, RANTES, fractalkine, and ICAM-1). Moreover, COS decreased the IκB degradation and p65 presence in the ICB, which resulted in the inhibition of NF-κB/DNA binding activity. In an in vitro study, sensitized spleen-derived lymphocytes of the COS-treated group showed less chemotaxis toward their aqueous humor and decreased secretion of the above inflammatory mediators in the culture media. COS treated EAAU by inhibiting the activation of NF-κB and reducing the expression of inflammatory mediators. COS might be a potential treatment for acute anterior uveitis.

scholarly journals Interaction Between the Complement System and Infectious Agents – A Potential Mechanistic Link to Neurodegeneration and Dementia

2021 ◽  
Vol 15 ◽  
Author(s):  
Noriko Shinjyo ◽  
Wataru Kagaya ◽  
Marcela Pekna
Keyword(s):  
Nervous System ◽  
Complement System ◽  
Complement Activation ◽  
Neural Plasticity ◽  
Measles Virus ◽  
System Development ◽  
Critical Role ◽  
Nervous System Development ◽  
Infectious Agents ◽  
The Complement System

As part of the innate immune system, complement plays a critical role in the elimination of pathogens and mobilization of cellular immune responses. In the central nervous system (CNS), many complement proteins are locally produced and regulate nervous system development and physiological processes such as neural plasticity. However, aberrant complement activation has been implicated in neurodegeneration, including Alzheimer’s disease. There is a growing list of pathogens that have been shown to interact with the complement system in the brain but the short- and long-term consequences of infection-induced complement activation for neuronal functioning are largely elusive. Available evidence suggests that the infection-induced complement activation could be protective or harmful, depending on the context. Here we summarize how various infectious agents, including bacteria (e.g., Streptococcus spp.), viruses (e.g., HIV and measles virus), fungi (e.g., Candida spp.), parasites (e.g., Toxoplasma gondii and Plasmodium spp.), and prion proteins activate and manipulate the complement system in the CNS. We also discuss the potential mechanisms by which the interaction between the infectious agents and the complement system can play a role in neurodegeneration and dementia.

Crucial Role of Apoptosis in the Resolution of Experimental Autoimmune Anterior Uveitis

2007 ◽  
Vol 48 (11) ◽  
pp. 5091 ◽  
Author(s):  
Purushottam Jha ◽  
Bharati Matta ◽  
Valeriy Lyzogubov ◽  
Ruslana Tytarenko ◽  
Puran S. Bora ◽  
...  
Keyword(s):  
Anterior Uveitis ◽  
Crucial Role ◽  
Experimental Autoimmune Anterior Uveitis ◽  
Experimental Autoimmune
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