Simvastatin Elicits Dilation of Isolated Porcine Retinal Arterioles: Role of Nitric Oxide and Mevalonate-Rho Kinase Pathways

2007 ◽  
Vol 48 (2) ◽  
pp. 825 ◽  
Author(s):  
Taiji Nagaoka ◽  
Travis W. Hein ◽  
Akitoshi Yoshida ◽  
Lih Kuo
Keyword(s):  
Nitric Oxide ◽  
Rho Kinase ◽  
Retinal Arterioles

Vasomodulatory effect of novel peroxovanadate compounds on rat aorta: Role of rho kinase and nitric oxide/cGMP pathway

2011 ◽  
Vol 64 (3) ◽  
pp. 274-282 ◽  
Author(s):  
Vivek Khanna ◽  
Manish Jain ◽  
Manoj Kumar Barthwal ◽  
Diganta Kalita ◽  
Jeena Jyoti Boruah ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Rho Kinase ◽  
Rat Aorta ◽  
Cgmp Pathway

Thromboxane prostanoid receptor activation impairs endothelial nitric oxide-dependent vasorelaxations: The role of Rho kinase

2009 ◽  
Vol 78 (4) ◽  
pp. 374-381 ◽  
Author(s):  
Cui Qing Liu ◽  
Fung Ping Leung ◽  
Siu Ling Wong ◽  
Wing Tak Wong ◽  
Chi Wai Lau ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Rho Kinase ◽  
Receptor Activation ◽  
Prostanoid Receptor ◽  
Endothelial Nitric Oxide

Rho kinase contributes to basal vascular tone in humans: role of endothelium-derived nitric oxide

2007 ◽  
Vol 293 (1) ◽  
pp. H541-H547 ◽  
Author(s):  
E. Büssemaker ◽  
Frank Pistrosch ◽  
Sarah Förster ◽  
Kay Herbrig ◽  
Peter Gross ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Vascular Tone ◽  
Rho Kinase ◽  
Calcium Sensitivity ◽  
Venous Occlusion ◽  
Dependent Manner ◽  
Endothelin 1 ◽  
Mlc Phosphorylation ◽  
Constrictor Response

Our objective was to determine the role of the Rho-associated kinase (ROK) for the regulation of FBF (FBF) and to unmask a potential role of ROK for the regulation of endothelium-derived nitric oxide (NO). Moreover, the effect of fasudil on the constrictor response to endothelin-1 was recorded. Regarding background, phosphorylation of the myosin light chain (MLC) determines the calcium sensitivity of the contractile apparatus. MLC phosphorylation depends on the activity of the MLC kinase and the MLC phosphatase. The latter enzyme is inhibited through phosphorylation by ROK. ROK has been suggested to inhibit NO generation, possibly via the inhibition of the Akt pathway. In this study, the effect of intra-arterial infusion of the ROK inhibitor fasudil on FBF in 12 healthy volunteers was examined by venous occlusion plethysmography. To unmask the role of NO, fasudil was infused during NO clamp. As a result, fasudil markedly increased FBF in a dose-dependent manner from 2.34 ± 0.21 to 6.96 ± 0.93 ml/100 ml forearm volume at 80 μg/min ( P < 0.001). At 1,600 μg/min, fasudil reduced systolic, diastolic, and mean arterial pressure while increasing heart rate. Fasudil abolished the vasoconstrictor effect of endothelin-1. The vascular response to fasudil (80 μmol/min) was blunted during NO clamp (104 ± 18% vs. 244 ± 48% for NO clamp + fasudil vs. fasudil alone; data as ratio between infused and noninfused arm with baseline = 0%, P < 0.05). In conclusion, 1) basal peripheral and systemic vascular tone depends on ROK; 2) a significant portion of fasudil-induced vasodilation is mediated by NO, suggesting that vascular bioavailable NO is negatively regulated by ROK; and 3) the constrictor response to endothelin involves the activation of ROK.

scholarly journals Multiscale modeling and simulation of neurovascular coupling in the retina

2018 ◽  
Vol 2 (2) ◽  
pp. 30-35
Author(s):  
Riccardo Sacco ◽  
Aurelio G. Mauri ◽  
Alessandra Cardani ◽  
Brent A. Siesky ◽  
Giovanna Guidoboni ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Mathematical Model ◽  
Diabetic Retinopathy ◽  
Multiscale Modeling ◽  
Neurovascular Coupling ◽  
Retinal Arterioles ◽  
Potent Vasodilator ◽  
Simulation Results ◽  
Flicker Light

The role of nitric oxide (NO), usually considered as a potent vasodilator, in regulating retinal neurovascular coupling is still elusive. Measurements of flicker light-induced functional hyperemia (FH) in humans show that an increase of NO levels reduces vasodilation. This evidence has led to conjecture that such an increase may be responsible for suppressing flicker-evoked vasodilation in diabetic retinopathy. In this paper, we propose a mathematical model to theoretically investigate the effect of an increase in neural NO (nNO) on the vasodilation of retinal arterioles. Simulation results indicate that nNO increase may:1. significantly aff ect vasoconstrictive agent production by glial cells; and2. elicit vasoconstriction rather than vasodilation in retinal arterioles.Model predictions seem therefore to support the conjecture that NO increase may be responsible for suppressing flicker-evoked vasodilation in diabetic retinopathy.

scholarly journals Acute retinal ischemia inhibits endothelium‐dependent nitric oxide‐mediated dilation of retinal arterioles: role of endothelin‐1 and superoxide

2008 ◽  
Vol 22 (S1) ◽  
Author(s):  
Travis W. Hein ◽  
Zhaoxu Yuan ◽  
Wenjuan Xu ◽  
Yi Ren ◽  
Elizabeth Roberts ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Retinal Ischemia ◽  
Endothelin 1 ◽  
Retinal Arterioles

scholarly journals Important Role of Rho-kinase in the Pathogenesis of Cardiovascular Inflammation and Remodeling Induced by Long-Term Blockade of Nitric Oxide Synthesis in Rats

Hypertension ◽  
2002 ◽  
Vol 39 (2) ◽  
pp. 245-250 ◽  
Author(s):  
Chu Kataoka ◽  
Kensuke Egashira ◽  
Shujiro Inoue ◽  
Masao Takemoto ◽  
Weihua Ni ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Rho Kinase ◽  
Nitric Oxide Synthesis
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