Corneal Innervation and Cellular Changes after Corneal Transplantation: An In Vivo Confocal Microscopy Study

2007 ◽  
Vol 48 (2) ◽  
pp. 621 ◽  
Author(s):  
Rachael L. Niederer ◽  
Divya Perumal ◽  
Trevor Sherwin ◽  
Charles N. J. McGhee
Keyword(s):  
Confocal Microscopy ◽  
Corneal Transplantation ◽  
Microscopy Study ◽  
In Vivo Confocal Microscopy ◽  
Corneal Innervation ◽  
Cellular Changes

Conjunctival findings in hyperbaric and low-tension glaucoma: an in vivo confocal microscopy study

2011 ◽  
Vol 90 (2) ◽  
pp. e132-e137 ◽  
Author(s):  
Luca Agnifili ◽  
Paolo Carpineto ◽  
Vincenzo Fasanella ◽  
Rodolfo Mastropasqua ◽  
Antonio Zappacosta ◽  
...  
Keyword(s):  
Confocal Microscopy ◽  
Microscopy Study ◽  
In Vivo Confocal Microscopy ◽  
Low Tension Glaucoma ◽  
Low Tension

scholarly journals In Vivo Confocal Microscopy Evaluation in Patients with Keratoconus

2022 ◽  
Vol 11 (2) ◽  
pp. 393
Author(s):  
Alvin Wei Jun Teo ◽  
Hassan Mansoor ◽  
Nigel Sim ◽  
Molly Tzu-Yu Lin ◽  
Yu-Chi Liu
Keyword(s):  
Confocal Microscopy ◽  
Nerve Regeneration ◽  
Nerve Fibre ◽  
Ex Vivo ◽  
Fibre Length ◽  
In Vivo Confocal Microscopy ◽  
Corneal Sensitivity ◽  
Mechanical Removal ◽  
Cellular Changes

Keratoconus is the most common primary corneal ectasia characterized by progressive focal thinning. Patients experience increased irregular astigmatism, decreased visual acuity and corneal sensitivity. Corneal collagen crosslinking (CXL), a minimally invasive procedure, is effective in halting disease progression. Historically, keratoconus research was confined to ex vivo settings. In vivo confocal microscopy (IVCM) has been used to examine the corneal microstructure clinically. In this review, we discuss keratoconus cellular changes evaluated by IVCM before and after CXL. Cellular changes before CXL include decreased keratocyte and nerve densities, disorganized subbasal nerves with thickening, increased nerve tortuosity and shortened nerve fibre length. Repopulation of keratocytes occurs up to 1 year post procedure. IVCM also correlates corneal nerve status to functional corneal sensitivity. Immediately after CXL, there is reduced nerve density and keratocyte absence due to mechanical removal of the epithelium and CXL effect. Nerve regeneration begins after 1 month, with nerve fibre densities recovering to pre-operative levels between 6 months to 1 year and remains stable up to 5 years. Nerves remain tortuous and nerve densities are reduced. Corneal sensitivity is reduced immediately postoperatively but recovers with nerve regeneration. Our article provides comprehensive review on the use of IVCM imaging in keratoconus patients.

Filtering blebs functionality after trabeculectomy: a clinical and in vivo confocal microscopy study

2014 ◽  
Vol 92 ◽  
pp. 0-0
Author(s):  
L VIEIRA ◽  
A SANTOS ◽  
M LISBOA ◽  
A AMARAL ◽  
JP CUNHA ◽  
...  
Keyword(s):  
Confocal Microscopy ◽  
Microscopy Study ◽  
In Vivo Confocal Microscopy

Innervation of Tissue-Engineered Corneal Implants in a Porcine Model: A 1-Year In Vivo Confocal Microscopy Study

2007 ◽  
Vol 48 (8) ◽  
pp. 3537 ◽  
Author(s):  
Neil S. Lagali ◽  
May Griffith ◽  
Naoshi Shinozaki ◽  
Per Fagerholm ◽  
Rejean Munger
Keyword(s):  
Confocal Microscopy ◽  
Porcine Model ◽  
Microscopy Study ◽  
In Vivo Confocal Microscopy

Peripheral neuropathy in Parkinson disease: An in vivo confocal microscopy study

2014 ◽  
Vol 92 ◽  
pp. 0-0 ◽  
Author(s):  
R ANJOS ◽  
L VIEIRA ◽  
A SOUSA ◽  
V MADURO ◽  
N ALVES ◽  
...  
Keyword(s):  
Peripheral Neuropathy ◽  
Confocal Microscopy ◽  
Parkinson Disease ◽  
Microscopy Study ◽  
In Vivo Confocal Microscopy
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