Structural and Functional Consequences of Trolox C Treatment in the Rat Model of Postnatal Hyperoxia

2006 ◽  
Vol 47 (3) ◽  
pp. 1101 ◽  
Author(s):  
Allison Lindsay Dorfman ◽  
Olga Dembinska ◽  
Sylvain Chemtob ◽  
Pierre Lachapelle
Keyword(s):  
Rat Model ◽  
Functional Consequences ◽  
Trolox C

In search of lost time: cognitive and arginine metabolic correlates of temporal dysfunction in the MIA rat model of schizophrenia risk

2021 ◽  
Author(s):  
Ashley Deane ◽  
Ping Liu ◽  
Reza Shoorangiz ◽  
Yu Jing ◽  
Ryan Ward
Keyword(s):  
Working Memory ◽  
Liquid Chromatography ◽  
Sustained Attention ◽  
Rat Model ◽  
High Performance ◽  
Working Memory Capacity ◽  
Preliminary Evidence ◽  
Late Gestation ◽  
Temporal Perception ◽  
Functional Consequences

Abnormal temporal perception is a hallmark characteristic of schizophrenia associated with cognitive impairment, however the relationship between these functions is yet to be characterised within translational models. Using the maternal immune activation (MIA) rat model, this study investigated the contribution of sustained attention and working memory capacity to temporal perception impairments via operant paradigms. In addition, we also investigated the involvement of L-arginine metabolites in timing and cognition via high performance liquid chromatography and liquid chromatography/mass spectrometry. Principally, we identified that underestimation of interval durations (2-8 s) in MIA rats was related to attentional capacity. MIA rats were found to exhibit impaired working memory maintenance, however this was not related to temporal perception. In addition, we identified evidence of MIA impacting PFC L-arginine metabolites, L-citrulline and putrescine, which both correlated with working memory maintenance impairments. MIA also appeared to produce discrete differences in glutamate levels depending on whether inflammation was incited early or late in gestation (gestation day 10/18). Following late gestation MIA exposure, higher glutamate levels in PFC corresponded with poorer sustained attention capacity. These findings represent the first direct identification of a timing-attention relationship within rodents, and provide clues regarding the potential involvement of elevated dopamine in timing-cognition pathology in schizophrenia. Moreover, we present preliminary evidence that changes in L-arginine metabolism have functional consequences for cognition. These outcomes commend the MIA rat model as a tool for potential future investigations exploring the biological instantiation of timing deficits.

scholarly journals Suppression of poly (ADP-ribose) polymerase activation by 3-aminobenzamide in a rat model of myocardial infarction: long-term morphological and functional consequences

2001 ◽  
Vol 133 (8) ◽  
pp. 1424-1430 ◽  
Author(s):  
Lucas Liaudet ◽  
Éva Szabó ◽  
Leonid Timashpolsky ◽  
László Virág ◽  
Attila Cziráki ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Rat Model ◽  
Functional Consequences

1045: Pioglitazone Ameliorates Penile Corpora Veno-Occlusive Dysfunction (CVOD) in a Rat Model of Type 2 Diabetes

2005 ◽  
Vol 173 (4S) ◽  
pp. 283-284
Author(s):  
Istvan Kovanecz ◽  
Monica G. Ferrini ◽  
Hugo H. Davila ◽  
Jacob Rajfer ◽  
Nestor F. Gonzalez-Cadavid
Keyword(s):  
Type 2 Diabetes ◽  
Rat Model

V1341: The Rat Model of Cavernous Nerve Injury: Practical Aspects

2005 ◽  
Vol 173 (4S) ◽  
pp. 364-365
Author(s):  
John F. Donohue ◽  
Michael Mullerad ◽  
Philip S. Li ◽  
Peter T. Scardino ◽  
John P. Mulhall
Keyword(s):  
Nerve Injury ◽  
Rat Model ◽  
Cavernous Nerve ◽  
Cavernous Nerve Injury

1441: Experimental Success of Biodegradable Conduit Graft for Regeneration and Reconnection of Transected Cavernous Nerves in a Rat Model

2004 ◽  
Vol 171 (4S) ◽  
pp. 379-380
Author(s):  
Shinichi Hisasue ◽  
Ryuichi Kato ◽  
Yoshikazu Sato ◽  
Takahiro Suetomi ◽  
Atsushi Takahashi ◽  
...  
Keyword(s):  
Rat Model ◽  
Cavernous Nerves

1713: Effect of Botulinum Toxin on Overactive Bladder Contractions Induced by Intra Vesical ATP and Capsaicin in the RAT Model

2004 ◽  
Vol 171 (4S) ◽  
pp. 453-453
Author(s):  
Humphrey O. Atiemo ◽  
Jacob Wynes ◽  
James Chuo ◽  
Lisa Nipkow ◽  
Geoffrey N. Sklar ◽  
...  
Keyword(s):  
Botulinum Toxin ◽  
Overactive Bladder ◽  
Rat Model
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