Vascular Damage in a Mouse Model of Diabetic Retinopathy: Relation to Neuronal and Glial Changes

2005 ◽  
Vol 46 (11) ◽  
pp. 4281 ◽  
Author(s):  
Rachel A. Feit-Leichman ◽  
Reiko Kinouchi ◽  
Masumi Takeda ◽  
Zhigang Fan ◽  
Susanne Mohr ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Mouse Model ◽  
Vascular Damage ◽  
Glial Changes

Does Neuronal Damage Precede Vascular Damage in Subjects with Type 2 Diabetes Mellitus and Having No Clinical Diabetic Retinopathy?

2012 ◽  
Vol 47 (4) ◽  
pp. 202-207 ◽  
Author(s):  
Aditya Verma ◽  
Rajiv Raman ◽  
K. Vaitheeswaran ◽  
Swakshyar Saumya Pal ◽  
Gella Laxmi ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Diabetic Retinopathy ◽  
Neuronal Damage ◽  
Vascular Damage

Paeoniflorin suppresses vascular damage and the expression of E-selectin and ICAM-1 in a mouse model of cutaneous Arthus reaction

2013 ◽  
Vol 22 (7) ◽  
pp. 453-457 ◽  
Author(s):  
Tao Chen ◽  
Zai-pei Guo ◽  
Lin Wang ◽  
Sha Qin ◽  
Na Cao ◽  
...  
Keyword(s):  
Mouse Model ◽  
Vascular Damage ◽  
Arthus Reaction

scholarly journals Role of endoplasmic reticulum stress in 12/15-lipoxygenase-induced retinal microvascular dysfunction in a mouse model of diabetic retinopathy

Diabetologia ◽  
2018 ◽  
Vol 61 (5) ◽  
pp. 1220-1232 ◽  
Author(s):  
Khaled Elmasry ◽  
Ahmed S. Ibrahim ◽  
Heba Saleh ◽  
Nehal Elsherbiny ◽  
Sally Elshafey ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Diabetic Retinopathy ◽  
Endoplasmic Reticulum Stress ◽  
Mouse Model ◽  
Microvascular Dysfunction

Neutrophil extracellular traps target senescent vasculature for tissue remodeling in retinopathy

Science ◽  
2020 ◽  
Vol 369 (6506) ◽  
pp. eaay5356
Author(s):  
François Binet ◽  
Gael Cagnone ◽  
Sergio Crespo-Garcia ◽  
Masayuki Hata ◽  
Mathieu Neault ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Diabetic Retinopathy ◽  
Mouse Model ◽  
Vascular Remodeling ◽  
Neutrophil Extracellular Traps ◽  
Developed Countries ◽  
Sterile Inflammation ◽  
Extracellular Traps ◽  
Retinal Blood Vessels ◽  
Underlying Mechanisms

In developed countries, the leading causes of blindness such as diabetic retinopathy are characterized by disorganized vasculature that can become fibrotic. Although many such pathological vessels often naturally regress and spare sight-threatening complications, the underlying mechanisms remain unknown. Here, we used orthogonal approaches in human patients with proliferative diabetic retinopathy and a mouse model of ischemic retinopathies to identify an unconventional role for neutrophils in vascular remodeling during late-stage sterile inflammation. Senescent vasculature released a secretome that attracted neutrophils and triggered the production of neutrophil extracellular traps (NETs). NETs ultimately cleared diseased endothelial cells and remodeled unhealthy vessels. Genetic or pharmacological inhibition of NETosis prevented the regression of senescent vessels and prolonged disease. Thus, clearance of senescent retinal blood vessels leads to reparative vascular remodeling.

scholarly journals Basigin can be a therapeutic target to restore the retinal vascular barrier function in the mouse model of diabetic retinopathy

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Mitsuru Arima ◽  
Dan Cui ◽  
Tokuhiro Kimura ◽  
Koh-Hei Sonoda ◽  
Tatsuro Ishibashi ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Mouse Model ◽  
Therapeutic Target ◽  
Barrier Function

scholarly journals Oxidative Stress and Light-Evoked Responses of the Posterior Segment in a Mouse Model of Diabetic Retinopathy

2015 ◽  
Vol 56 (1) ◽  
pp. 606-615 ◽  
Author(s):  
B. A. Berkowitz ◽  
E. M. Grady ◽  
N. Khetarpal ◽  
A. Patel ◽  
R. Roberts
Keyword(s):  
Oxidative Stress ◽  
Diabetic Retinopathy ◽  
Mouse Model ◽  
Posterior Segment ◽  
Evoked Responses

Vascular damage of retina in diabetic retinopathy and its treatment

2012 ◽  
Vol 7 (1) ◽  
pp. 73-86
Author(s):  
Jayamanti Pandit ◽  
Yasmin Sultana
Keyword(s):  
Diabetic Retinopathy ◽  
Vascular Damage

scholarly journals 5-Lipoxygenase, but Not 12/15-Lipoxygenase, Contributes to Degeneration of Retinal Capillaries in a Mouse Model of Diabetic Retinopathy

Diabetes ◽  
2008 ◽  
Vol 57 (5) ◽  
pp. 1387-1393 ◽  
Author(s):  
R. A. Gubitosi-Klug ◽  
R. Talahalli ◽  
Y. Du ◽  
J. L. Nadler ◽  
T. S. Kern
Keyword(s):  
Diabetic Retinopathy ◽  
Mouse Model ◽  
Retinal Capillaries

Pure neuroretinal dysfunction in diabetic retinopathy occurring prior to endothelial and vascular damage

2013 ◽  
Vol 91 ◽  
pp. 0-0
Author(s):  
A REIS ◽  
C MATEUS ◽  
P MELO ◽  
J FIGUEIRA ◽  
J CUNHA-VAZ ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Vascular Damage
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