Decorin Modulates Wound Healing in Experimental Glaucoma Filtration Surgery: A Pilot Study

2005 ◽  
Vol 46 (1) ◽  
pp. 191 ◽  
Author(s):  
Salvatore Grisanti ◽  
Peter Szurman ◽  
Max Warga ◽  
Radoslaw Kaczmarek ◽  
Focke Ziemssen ◽  
...  
Keyword(s):  
Wound Healing ◽  
Pilot Study ◽  
Filtration Surgery ◽  
Glaucoma Filtration Surgery ◽  
Experimental Glaucoma

scholarly journals Adenovirus-mediated delivery of p27KIP1 to prevent wound healing after experimental glaucoma filtration surgery

2009 ◽  
Vol 30 (4) ◽  
pp. 413-423 ◽  
Author(s):  
Jian-gang Yang ◽  
Nai-xue Sun ◽  
Li-jun Cui ◽  
Xiao-hua Wang ◽  
Zhao-hui Feng
Keyword(s):  
Wound Healing ◽  
Filtration Surgery ◽  
Glaucoma Filtration Surgery ◽  
Experimental Glaucoma

scholarly journals A Pilot Study on Ocular Safety and Efficacy of Infliximab as an Antifibrotic Agent After Experimental Glaucoma Filtration Surgery

2017 ◽  
Vol 6 (2) ◽  
pp. 323-334 ◽  
Author(s):  
Eleni Nikita ◽  
Alexandre Moulin ◽  
Ioannis Vergados ◽  
Dimitrios Brouzas ◽  
Panagiotis G. Theodossiadis
Keyword(s):  
Pilot Study ◽  
Filtration Surgery ◽  
Glaucoma Filtration Surgery ◽  
Safety And Efficacy ◽  
Experimental Glaucoma ◽  
Ocular Safety

scholarly journals Epigenetic Modification Prevents Excessive Wound Healing and Scar Formation After Glaucoma Filtration Surgery

2016 ◽  
Vol 57 (7) ◽  
pp. 3381 ◽  
Author(s):  
Ajay Sharma ◽  
Govindaraj Anumanthan ◽  
Marcos Reyes ◽  
Huiyi Chen ◽  
Jacob W. Brubaker ◽  
...  
Keyword(s):  
Wound Healing ◽  
Epigenetic Modification ◽  
Scar Formation ◽  
Filtration Surgery ◽  
Glaucoma Filtration Surgery

In Vitro Effect of Ascorbic Acid on the Proliferation of Bovine Scleral and Tenon's Capsule Fibroblasts

1998 ◽  
Vol 8 (1) ◽  
pp. 37-41 ◽  
Author(s):  
P.O. Denk ◽  
M. Knorr
Keyword(s):  
Wound Healing ◽  
Ascorbic Acid ◽  
Healing Process ◽  
Wound Healing Process ◽  
Filtration Surgery ◽  
Glaucoma Filtration Surgery ◽  
Tenon’S Capsule ◽  
Tenon's Capsule ◽  
Vitro Effect

The success of glaucoma filtration surgery depends mainly on an incomplete wound healing process in the area of the fistula. Since Kornblueth and Tenenbaum's investigations in 1956 it has been known that aqueous humour has intrinsic antiproliferative properties. It is assumed that ascorbic acid is involved in the regulation of the wound healing process after filtration surgery. To evaluate the antiproliferative effect of ascorbic acid in vitro, we used cultured fibroblasts of bovine Tenon's capsule and bovine sclera. Incubation of these cells with ascorbic acid at concentrations ranging from 0.5 to 3 mM/L led to dose-dependent inhibition of cell proliferation. The half-maximal inhibitory concentration was 1.0 mM/L for both cell types. Physiological concentrations of ascorbic acid may be valuable in the pharmacological prevention of failure of glaucoma filtration surgery. However, extensive clinical investigations are needed to clarify whether topical intraoperative or postoperative as well as oral administration of ascorbic acid inhibits fibroblast proliferation after glaucoma filtration surgery.

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