Prolonged Antiscarring Effects of Ilomastat and MMC after Experimental Glaucoma Filtration Surgery

2005 ◽  
Vol 46 (6) ◽  
pp. 2018 ◽  
Author(s):  
Tina T. L. Wong ◽  
Anna L. Mead ◽  
Peng T. Khaw
Keyword(s):  
Filtration Surgery ◽  
Glaucoma Filtration Surgery ◽  
Experimental Glaucoma

Decorin Modulates Wound Healing in Experimental Glaucoma Filtration Surgery: A Pilot Study

2005 ◽  
Vol 46 (1) ◽  
pp. 191 ◽  
Author(s):  
Salvatore Grisanti ◽  
Peter Szurman ◽  
Max Warga ◽  
Radoslaw Kaczmarek ◽  
Focke Ziemssen ◽  
...  
Keyword(s):  
Wound Healing ◽  
Pilot Study ◽  
Filtration Surgery ◽  
Glaucoma Filtration Surgery ◽  
Experimental Glaucoma

Cellular Proliferation After Experimental Glaucoma Filtration Surgery

1988 ◽  
Vol 106 (1) ◽  
pp. 89-94 ◽  
Author(s):  
H. D. Jampel ◽  
L. J. B. McGuigan ◽  
G. R. Dunkelberger ◽  
N. L. L'Hernault ◽  
H. A. Quigley
Keyword(s):  
Cellular Proliferation ◽  
Filtration Surgery ◽  
Glaucoma Filtration Surgery ◽  
Experimental Glaucoma

scholarly journals Development of Targeted siRNA Nanocomplexes to Prevent Fibrosis in Experimental Glaucoma Filtration Surgery

2018 ◽  
Vol 26 (12) ◽  
pp. 2812-2822 ◽  
Author(s):  
Owen Fernando ◽  
Aristides D. Tagalakis ◽  
Sahar Awwad ◽  
Steve Brocchini ◽  
Peng T. Khaw ◽  
...  
Keyword(s):  
Filtration Surgery ◽  
Glaucoma Filtration Surgery ◽  
Experimental Glaucoma

scholarly journals Antiscarring effect of intraoperative bevacizumab in experimental glaucoma filtration surgery

2018 ◽  
Vol 81 (4) ◽  
Author(s):  
Christiana Rebello Hilgert ◽  
Alvaro Haverroth Hilgert ◽  
Alexandre Nakao Odashiro ◽  
Patricia Rusa Pereira Odashiro ◽  
Augusto Paranhos Júnior
Keyword(s):  
Filtration Surgery ◽  
Glaucoma Filtration Surgery ◽  
Experimental Glaucoma

scholarly journals NOVO MODELO EXPERIMENTAL DE GLAUCOMA EM CÃO PARA O ESTUDO DA CICATRIZAÇÃO APÓS CIRURGIA FILTRANTE ASSOCIADA AO USO DE AGENTE ANTIFIBRÓTICO

1999 ◽  
Vol 4 (1) ◽  
Author(s):  
ANTONIO FELIPE P.F. WOUK ◽  
SILVANA CÍRIO ◽  
GIULIANA GELBECK KASECKER ◽  
CASSIANA RAMOS ◽  
ROSANA KELLER RICHTER
Keyword(s):  
Acetylsalicylic Acid ◽  
Animal Species ◽  
Physiological Solution ◽  
Filtration Surgery ◽  
Glaucoma Filtration Surgery ◽  
The Third ◽  
Experimental Glaucoma ◽  
Pharmacological Tests ◽  
Collateral Effects ◽  
Histopathologic Evaluation

Inicialmente três cães (6 olhos) foram submetidos ã injeções intracamerais de uma solução fisiológica saturada com micropartículas de grafite buscando-se a obtenção do glaucoma experimental. Ao final de 8 semanas constatou-se, de forma homogênea, glaucomas absolutos em todos os olhos. Na seqüência produziu-se, segundo este modelo, glaucoma em outros 9 cães (18 olhos), cada animal sendo submetido a dois tipos de cirurgia filtrantetrabeculectomia e iridencleise- e a dois tratamentos transoperatórios antifibróticos Mitomicina C e ácido acetil salicílico. As unidades experimentais assim constituídas foram estudadas clinicamente e histopatologicamente, com evidências aos 3, 6 e 12 meses de pós-operatório. O procedimento cirúrgico mais eficaz, independente do tratamento antifibrótico associado, foi a iridencleise, evidenciado por uma bolha de filtração patente um ano após a intervenção. O ácido acetil salicílico mostrou resultados antifibróticos superiores à Mitomicina C e ao contrário desta última, sem apresentar efeitos colaterais como globos hipotônicos. É lícito propor este novo modelo experimental de glaucoma para outras espécies por ser simples, barato, além de atuar como um "marcador" histológico do "caminho" do aquoso. Além disto poderá ser novamente empregado no cão visando testar outras técnicas de cirurgia filtrante e outros protocolos farmacológicos do glaucoma mas para sobretudo consolidar os estudos do uso do Ácido Acetil Salicílico como agente antifibrótico no olho. Abstract Experimental glaucoma was produced in all the eyes of three dogs by means of intracameral injections of physiological solution saturated with graphite microparticles. Homogeneous absolute glaucomas were then obtained by means of this technique. They were evidenced eight weeks after the intracameral injections. Following this experimental model, glaucomas were obtained in other 9 dogs. Each animal was subjected to two types of surgery, that is, filtration trabeculectomy and iridencleisis and by two antifibrotic topical treatments during the surgery with Mitomicin C and acetylsalicylic acid. Clinical and histopathologic evaluation of the experimental units were performed with emphasis in the third, sixth and twelve months after surgery. Iridencleise showed to be the most efficient surgical procedure in spite of being associated to the antifibrotic treatment. Acetylsalicylic acid displayed better antifibrotic activity than Mytomicin C showing no collateral effects as the formation of hypotonic globes for instance. This new glaucoma model may also be used for other animal species. Besides being simple and inexpensive it acts as a graphite histologic “marker” of the aqueous humor “path”. Moreover, it allows to be used in the dog in pharmacological tests as well as in other protocols of glaucoma filtration surgery, specially in studies regarding the use of acetylsalicylic acid as eye antifibrotic agent.

Modulation of Postoperative Scarring with Tacrolimus and Octreotide in Experimental Glaucoma Filtration Surgery

2012 ◽  
Vol 37 (3) ◽  
pp. 228-233 ◽  
Author(s):  
Sermal Arslan ◽  
Orhan Aydemir ◽  
Mete Güler ◽  
Adile Ferda Dağlı
Keyword(s):  
Filtration Surgery ◽  
Glaucoma Filtration Surgery ◽  
Experimental Glaucoma
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