scholarly journals Microglial mechanisms of experience-dependent plasticity in the mouse visual cortex

2019 ◽  
Vol 19 (15) ◽  
pp. 18
Author(s):  
Ania K. Majewska
Keyword(s):  
Visual Cortex ◽  
Dependent Plasticity ◽  
Mouse Visual Cortex

Reversible blockade of experience-dependent plasticity by calcineurin in mouse visual cortex

2005 ◽  
Vol 8 (6) ◽  
pp. 791-796 ◽  
Author(s):  
Yupeng Yang ◽  
Quentin S Fischer ◽  
Ying Zhang ◽  
Karsten Baumgärtel ◽  
Isabelle M Mansuy ◽  
...  
Keyword(s):  
Visual Cortex ◽  
Dependent Plasticity ◽  
Mouse Visual Cortex

scholarly journals H3 and H4 Lysine Acetylation Correlates with Developmental and Experimentally Induced Adult Experience-Dependent Plasticity in the Mouse Visual Cortex

2016 ◽  
Vol 10s1 ◽  
pp. JEN.S39888 ◽  
Author(s):  
Gabriela Vierci ◽  
Bruno Pannunzio ◽  
Natalia Bornia ◽  
Francesco M. Rossi
Keyword(s):  
Visual Cortex ◽  
Posttranslational Modifications ◽  
Visual Experience ◽  
High Plasticity ◽  
Experimental Conditions ◽  
Dynamic Regulation ◽  
Dependent Plasticity ◽  
Fluoxetine Treatment ◽  
Mouse Visual Cortex ◽  
Adult Plasticity

Histone posttranslational modifications play a fundamental role in orchestrating gene expression. In this work, we analyzed the acetylation of H3 and H4 histones (AcH3-AcH4) and its modulation by visual experience in the mouse visual cortex (VC) during normal development and in two experimental conditions that restore juvenile-like plasticity levels in adults (fluoxetine treatment and enriched environment). We found that AcH3-AcH4 declines with age and is upregulated by treatments restoring plasticity in the adult. We also found that visual experience modulates AcH3-AcH4 in young and adult plasticity-restored mice but not in untreated ones. Finally, we showed that the transporter vGAT is downregulated in adult plasticity-restored models. In summary, we identified a dynamic regulation of AcH3-AcH4, which is associated with high plasticity levels and enhanced by visual experience. These data, along with recent ones, indicate H3-H4 acetylation as a central hub in the control of experience-dependent plasticity in the VC.

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