scholarly journals Measuring the Temporal Contrast Sensitivity Function and Macular Pigment Optical Density in Older Adults with and Without Cognitive Impairment

2011 ◽  
Vol 11 (15) ◽  
pp. 35-35
Author(s):  
M. Dengler ◽  
A. Thorne ◽  
A. Puente ◽  
A. Watts ◽  
B. Hammond ◽  
...  
Keyword(s):  
Older Adults ◽  
Cognitive Impairment ◽  
Contrast Sensitivity ◽  
Optical Density ◽  
Macular Pigment ◽  
Sensitivity Function ◽  
Contrast Sensitivity Function ◽  
Macular Pigment Optical Density ◽  
Temporal Contrast

scholarly journals Clinical Effects of Dietary Supplementation of Lutein with High Bio-Accessibility on Macular Pigment Optical Density and Contrast Sensitivity: A Randomized Double-Blind Placebo-Controlled Parallel-Group Comparison Trial

Nutrients ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 2966
Author(s):  
Naomichi Machida ◽  
Marie Kosehira ◽  
Nobuyoshi Kitaichi
Keyword(s):  
Placebo Group ◽  
Contrast Sensitivity ◽  
Optical Density ◽  
Macular Pigment ◽  
Clinical Effects ◽  
Macular Pigment Optical Density ◽  
Continuous Administration ◽  
Double Blind ◽  
Comparison Trial ◽  
Glare Sensitivity

Improvements in macular pigment optical density (MPOD) and contrast sensitivity after administration of 12 mg lutein alone and the timing at which efficacy is observed remain unknown. Therefore, lutein (12 mg), a crystalline formulation, was used in this study, considering its bioaccessibility. This study aimed to determine the effects of lutein administration for 16 weeks on MPOD, contrast sensitivity, and glare sensitivity, and changes in serum lutein levels were determined. The study subjects comprised 59 healthy male and female adults aged 20–69 years. The study diet included a placebo (placebo group) or a diet supplemented with 12 mg of lutein (lutein group). Each study diet was continuously administered for 16 weeks. At weeks 8 and 16, MPOD, contrast sensitivity, glare sensitivity, and serum lutein levels were evaluated. Compared with the placebo group, the lutein group showed significantly improved MPOD, contrast sensitivity, and glare sensitivity at week 16 and significantly increased serum lutein levels at weeks 8 and 16. Continuous administration of lutein for 16 weeks, considering its bioaccessibility, increased MPOD; it made the outlines of visible objects clearer and was effective in inhibiting decreases in visual function caused by glare from light.

scholarly journals Rod-Mediated Dark Adaptation and Macular Pigment Optical Density in Older Adults with Normal Maculas

2018 ◽  
Vol 43 (7) ◽  
pp. 913-920 ◽  
Author(s):  
Anna V. Zarubina ◽  
Carrie E. Huisingh ◽  
Mark E. Clark ◽  
Kenneth R. Sloan ◽  
Gerald McGwin ◽  
...  
Keyword(s):  
Older Adults ◽  
Optical Density ◽  
Dark Adaptation ◽  
Macular Pigment ◽  
Macular Pigment Optical Density

scholarly journals A practical method of measuring the human 
temporal contrast sensitivity function

2010 ◽  
Vol 1 (1) ◽  
pp. 47 ◽  
Author(s):  
Billy R. Wooten ◽  
Lisa M. Renzi ◽  
Robert Moore ◽  
Billy R. Hammond
Keyword(s):  
Contrast Sensitivity ◽  
Practical Method ◽  
Sensitivity Function ◽  
Contrast Sensitivity Function ◽  
Temporal Contrast

scholarly journals Low macular pigment optical density is associated with lower cognitive performance in a large, population-based sample of older adults

2013 ◽  
Vol 34 (11) ◽  
pp. 2449-2456 ◽  
Author(s):  
Joanne Feeney ◽  
Ciarán Finucane ◽  
George M. Savva ◽  
Hilary Cronin ◽  
Stephen Beatty ◽  
...  
Keyword(s):  
Older Adults ◽  
Cognitive Performance ◽  
Optical Density ◽  
Large Population ◽  
Population Based ◽  
Macular Pigment ◽  
Macular Pigment Optical Density

scholarly journals Efficacy of Commercially Available Nutritional Supplements: Analysis of Serum Uptake, Macular Pigment Optical Density and Visual Functional Response

Nutrients ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1321
Author(s):  
Richard A. Bone ◽  
Pinakin Gunvant Davey ◽  
Betzabe O. Roman ◽  
David W. Evans
Keyword(s):  
Contrast Sensitivity ◽  
Optical Density ◽  
Visual Function ◽  
Nutritional Supplements ◽  
Serum Levels ◽  
Macular Pigment ◽  
Macular Pigment Optical Density ◽  
Significant Elevation ◽  
Carotenoid Concentration ◽  
Serum Carotenoids

Purpose: To compare the change in serum carotenoids, macular pigment optical density (MPOD) and visual function with the intake of two commercially available nutritional supplements. Methods: Participants were given a 24-week supply of a lipid-based micronized liquid medical food, Lumega-Z™ (LM), containing 28 mg of the macular carotenoids lutein (L), zeaxanthin (Z) and meso-zeaxanthin (MZ), or given PreserVision™ AREDS 2 Formula (gel-caps; PV) containing 12 mg of the macular carotenoids L and Z, but no reported MZ. Serum levels of L, Z and MZ were obtained at baseline and after 12 weeks. Macular pigment optical densities (MPOD) and visual function were assessed at baseline and after 24 weeks. Results: Average blood serum concentrations of L, Z and MZ in the two groups at baseline were similar. The increases in L, Z and MZ were 0.434, 0.063 and 0.086 µmol/L vs. 0.100, 0.043 and 0.001 µmol/L, respectively, in the LM vs. PV group. From baseline to week 24, average MPOD in the LM-group increased by 0.064 from 0.418 to 0.482, whereas in the PV-group, it was essentially unchanged (0.461 to 0.459;). Although log-contrast sensitivity was improved in all groups under three conditions (photopic, mesopic and mesopic with glare), the change in log-contrast sensitivity was not statistically significant. Conclusion: Despite only a 2.3-fold higher carotenoid concentration than PV, LM supplementation provides approximately 3–4-fold higher absorption, which leads to a significant elevation of MPOD levels.

scholarly journals Plasma Concentrations of Lutein and Zeaxanthin, Macular Pigment Optical Density, and Their Associations With Cognitive Performances Among Older Adults

2018 ◽  
Vol 59 (5) ◽  
pp. 1828 ◽  
Author(s):  
Soufiane Ajana ◽  
Daniela Weber ◽  
Catherine Helmer ◽  
Bénédicte M. Merle ◽  
Wolfgang Stuetz ◽  
...  
Keyword(s):  
Older Adults ◽  
Optical Density ◽  
Plasma Concentrations ◽  
Macular Pigment ◽  
Macular Pigment Optical Density
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