Gold-Nanoparticle Layer Substrate Assisted Transmission-Mode Laser Desorption for Atmospheric Pressure Mass Spectrometry Imaging

2020 ◽  
Vol 12 (10) ◽  
pp. 1517-1523
Author(s):  
Jae Young Kim ◽  
Heejin Lim ◽  
Sun Young Lee ◽  
Gwanjin Lee ◽  
Dong-Kwon Lim ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Gold Nanoparticle ◽  
Atmospheric Pressure ◽  
Mass Spectrometry Imaging ◽  
Continuous Wave ◽  
Continuous Wave Laser ◽  
Fresh Tissue ◽  
Mode Laser ◽  
Nanoparticle Layer ◽  
Wave Laser

We demonstrate continuous-wave laser-based ambient mass spectrometry imaging with the use of a gold-nanoparticle layer substrate. When a fresh tissue slice is placed on a gold-nanoparticle layer substrate and irradiated with a 532-nm continuous-wave laser, the transmission-mode laser configuration provides precise desorption performance to facilitate mass spectrometry imaging. The subsequent ionization process with nonthermal atmospheric pressure plasma jets generates sufficient amounts of molecular ions. By using this method, micrometer-spatial-resolution mass spectrometry imaging of humid tissues can be obtained. The gold-nanoparticle layer substrates can be prepared and stored in advance of the experiment, resulting in simplified specimen preparation and an advantage in faster preparing of fresh tissue specimen for analysis.

scholarly journals Nanomaterials and continuous wave laser-based efficient desorption for atmospheric pressure mass spectrometric imaging of live hippocampal tissue slices

RSC Advances ◽  
2018 ◽  
Vol 8 (15) ◽  
pp. 8021-8025 ◽  
Author(s):  
Jae Young Kim ◽  
Eun Seok Seo ◽  
Hee Jin Lim ◽  
Hyunmin Kim ◽  
Ji-Won Park ◽  
...  
Keyword(s):  
Atmospheric Pressure ◽  
Continuous Wave ◽  
Mass Spectrometric ◽  
Continuous Wave Laser ◽  
Mass Spectrometric Imaging ◽  
Tissue Slices ◽  
Hippocampal Tissue ◽  
Wave Laser ◽  
532 Nm ◽  
Resolution Mass

Micrometer-resolution mass spectrometric imaging of live hippocampal tissue is achieved with a highly efficient desorption of biomolecules using a 532 nm continuous wave laser and gold nanoparticles or graphene oxide as an energy transporter.

1848: Revolix 70 Watt 2 Micron Continuous Wave Laser Vaporesection of the Prostate. Preliminary Results After a One Year Follow-Up

2007 ◽  
Vol 177 (4S) ◽  
pp. 614-614
Author(s):  
Thorsten Bach ◽  
Thomas R.W. Herrmann ◽  
Roman Ganzer ◽  
Andreas J. Gross
Keyword(s):  
Continuous Wave ◽  
Continuous Wave Laser ◽  
Preliminary Results ◽  
Wave Laser ◽  
One Year

scholarly journals High-precision optical fiber pressure sensor using frequency-modulated continuous-wave laser interference

AIP Advances ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 025038
Author(s):  
Lang Bai ◽  
Gang Zheng ◽  
Bin Sun ◽  
Xiongxing Zhang ◽  
Qiming Sheng ◽  
...  
Keyword(s):  
Optical Fiber ◽  
High Precision ◽  
Pressure Sensor ◽  
Continuous Wave ◽  
Continuous Wave Laser ◽  
Laser Interference ◽  
Wave Laser

Continuous wave laser probed thermal nonlinearity in TiO2 and TiO2-dye nano colloidal

2021 ◽  
Vol 142 ◽  
pp. 107182
Author(s):  
S. Pramodini ◽  
L.S. Aravinda ◽  
K.K. Nagaraja ◽  
P. Poornesh
Keyword(s):  
Continuous Wave ◽  
Continuous Wave Laser ◽  
Thermal Nonlinearity ◽  
Wave Laser

scholarly journals Spatiotemporal Visualization of Insecticides and Fungicides within Fruits and Vegetables Using Gold Nanoparticle-Immersed Paper Imprinting Mass Spectrometry Imaging

Nanomaterials ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 1327
Author(s):  
Run Qin ◽  
Ping Li ◽  
Mingyi Du ◽  
Lianlian Ma ◽  
Yudi Huang ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Food Safety ◽  
Gold Nanoparticle ◽  
Pesticide Residue ◽  
Rational Design ◽  
Mass Spectrometry Imaging ◽  
Fruits And Vegetables ◽  
Detection Methods ◽  
Safety Issues ◽  
Spatiotemporal Visualization

Food safety issues caused by pesticide residue have exerted far-reaching impacts on human daily life, yet the available detection methods normally focus on surface residue rather than pesticide penetration to the internal area of foods. Herein, we demonstrated gold nanoparticle (AuNP)-immersed paper imprinting mass spectrometry imaging (MSI) for monitoring pesticide migration behaviors in various fruits and vegetables (i.e., apple, cucumber, pepper, plum, carrot, and strawberry). By manually stamping food tissues onto AuNP-immersed paper, this method affords the spatiotemporal visualization of insecticides and fungicides within fruits and vegetables, avoiding tedious and time-consuming sample preparation. Using the established MSI platform, we can track the migration of insecticides and fungicides into the inner region of foods. The results revealed that both the octanol-water partition coefficient of pesticides and water content of garden stuffs could influence the discrepancy in the migration speed of pesticides into food kernels. Taken together, this nanopaper imprinting MSI is poised to be a powerful tool because of its simplicity, rapidity, and easy operation, offering the potential to facilitate further applications in food analysis. Moreover, new perspectives are given to provide guidelines for the rational design of novel pesticide candidates, reducing the risk of food safety issues caused by pesticide residue.

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