Epithelial Cellular Adhesion Molecule rs1126497 Polymorphism Contributes to Gastric Cancer Susceptibility: A Case-Control Study

2016 ◽  
Vol 16 (12) ◽  
pp. 12684-12690
Author(s):  
Xiang Ma ◽  
Younan Wang ◽  
Chao Yang ◽  
Ran Tang ◽  
Zekuan Xu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Adhesion Molecule ◽  
Case Control Study ◽  
Cancer Susceptibility ◽  
Case Control ◽  
Cellular Adhesion ◽  
Cellular Adhesion Molecule ◽  
Control Study

scholarly journals Predictive Value of MiR-219-1, MiR-938, MiR-34b/c, and MiR-218 Polymorphisms for Gastric Cancer Susceptibility and Prognosis

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Yanhua Wu ◽  
Zhifang Jia ◽  
Donghui Cao ◽  
Chuan Wang ◽  
Xing Wu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Survival Analysis ◽  
Distant Metastasis ◽  
Case Control Study ◽  
Cancer Susceptibility ◽  
Case Control ◽  
Cancer Prognosis ◽  
Radical Operation ◽  
Risk Of Death ◽  
Control Study

Gastric cancer (GC) is one of the most prominent global cancer-related health threats. Genes play a key role in the precise mechanisms of gastric cancer. SNPs in mi-RNAs could affect mRNA expression and then affect the risk and prognosis of GC. Firstly, we have decided to perform a case-control study which included 897 GC patients and 992 controls to evaluate the association of miR-219-1 rs213210, miR-938 rs2505901, miR-34b/c rs4938723, and miR-218 rs11134527 polymorphisms with gastric cancer susceptibility. Secondly, among the 897 GC patients above, 755 cases underwent a radical operation, without distant metastasis and with negative surgical margins included in the survival analysis to evaluate the association of the four SNPs above with gastric cancer prognosis. The C/T or C/C genotypes of rs213210 were related to a lower GC risk (OR = 0.76, 95% CI: 0.62–0.93,P=0.009) compared to the T/T genotype. Rs11134527 in miR-218 was associated with GC survival, and the G/A and G/G genotypes of rs11134527 resulted in a decreased risk of death when compared with the A/A genotype (HR = 0.75, 95% CI: 0.61–0.95,P=0.016). This study found that miR-219-1 rs213210 polymorphism was associated with GC susceptibility and rs11134527 in miR-218 was positively correlated with GC prognosis.

TGFBR1tagging SNPs and gastric cancer susceptibility: A two-stage case-control study in chinese population

2012 ◽  
Vol 53 (2) ◽  
pp. 109-116 ◽  
Author(s):  
Jianjian Chen ◽  
Lin Miao ◽  
Guangfu Jin ◽  
Chuanli Ren ◽  
Qiao Ke ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Chinese Population ◽  
Case Control Study ◽  
Cancer Susceptibility ◽  
Case Control ◽  
Two Stage ◽  
Control Study

scholarly journals The Association of MEG3 Gene rs7158663 Polymorphism With Cancer Susceptibility

2021 ◽  
Vol 11 ◽  
Author(s):  
Xueren Gao ◽  
Xianyang Li ◽  
Shulong Zhang ◽  
Xiaoting Wang
Keyword(s):  
Breast Cancer ◽  
Gastric Cancer ◽  
Case Control Study ◽  
Cancer Susceptibility ◽  
Direct Sequencing ◽  
Meta Analysis ◽  
Case Control ◽  
Control Study ◽  
Increased Susceptibility ◽  
Cancer Bioinformatics

Although the association of MEG3 gene rs7158663 polymorphism with cancer susceptibility has been investigated, the findings are inconsistent. The aim of this study was to analyze the association between the rs7158663 polymorphism and cancer susceptibility through a case-control study and meta-analysis. In a case-control study with 430 colorectal cancer (CRC) cases and 445 healthy controls, the rs7158663 polymorphism was genotyped by direct sequencing. STATA software was used to calculate the pooled odds ratio and 95% confidence interval in a meta-analysis including 4,649 cancer cases and 5,590 controls. Both the case-control study and meta-analysis showed that the rs7158663 polymorphism was associated with increased susceptibility to CRC. Individuals carrying the AA or GA genotype were more likely to develop CRC than those carrying the rs7158663 GG genotype. Interestingly, MEG3 expression was significantly lower in colorectal tissues of the AA or GA genotype compared to those of the rs7158663 GG genotype. In addition, the meta-analysis suggested that the rs7158663 polymorphism was also associated with increased susceptibility to breast cancer and gastric cancer. Bioinformatics analysis showed that the rs7158663 A allele contributed to the binding of hsa-miR-4307 and hsa-miR-1265 to MEG3. In conclusion, the current findings suggest that the MEG3 gene rs7158663 polymorphism may serve as a genetic marker for predicting the risk of cancers, such as breast cancer, gastric cancer and CRC. However, the sample size of the current study is still insufficient, especially in the subgroup analysis. Therefore large and well-designed studies are needed to validate our findings.

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