Control of Stem Cell Fate and Function by Polymer Nanofibers

2016 ◽  
Vol 16 (9) ◽  
pp. 9015-9021 ◽  
Author(s):  
Deepti Rana ◽  
Maria Leena ◽  
Manasseh Nithyananth ◽  
Renu Pasricha ◽  
Geetha Manivasagam ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Fate ◽  
Polymer Nanofibers ◽  
Stem Cell Fate ◽  
And Function

scholarly journals Polycomb/Trithorax Antagonism: Cellular Memory in Stem Cell Fate and Function

2019 ◽  
Vol 24 (4) ◽  
pp. 518-533 ◽  
Author(s):  
Marjorie Brand ◽  
Kiran Nakka ◽  
Jiayu Zhu ◽  
F. Jeffrey Dilworth
Keyword(s):  
Stem Cell ◽  
Cell Fate ◽  
Cellular Memory ◽  
Stem Cell Fate ◽  
And Function

Constructing stem cell microenvironments using bioengineering approaches

2013 ◽  
Vol 45 (23) ◽  
pp. 1123-1135 ◽  
Author(s):  
David A. Brafman
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Cell Fate ◽  
Disease Modeling ◽  
Mechanical Stimuli ◽  
Culture Methods ◽  
Stem Cell Fate ◽  
And Function

Within the adult organism, stem cells reside in defined anatomical microenvironments called niches. These architecturally diverse microenvironments serve to balance stem cell self-renewal and differentiation. Proper regulation of this balance is instrumental to tissue repair and homeostasis, and any imbalance can potentially lead to diseases such as cancer. Within each of these microenvironments, a myriad of chemical and physical stimuli interact in a complex (synergistic or antagonistic) manner to tightly regulate stem cell fate. The in vitro replication of these in vivo microenvironments will be necessary for the application of stem cells for disease modeling, drug discovery, and regenerative medicine purposes. However, traditional reductionist approaches have only led to the generation of cell culture methods that poorly recapitulate the in vivo microenvironment. To that end, novel engineering and systems biology approaches have allowed for the investigation of the biological and mechanical stimuli that govern stem cell fate. In this review, the application of these technologies for the dissection of stem cell microenvironments will be analyzed. Moreover, the use of these engineering approaches to construct in vitro stem cell microenvironments that precisely control stem cell fate and function will be reviewed. Finally, the emerging trend of using high-throughput, combinatorial methods for the stepwise engineering of stem cell microenvironments will be explored.

The PRO-inflammatory cytokine interleukin-1 is a key regulator of hematopoietic Stem cell fate and function

2016 ◽  
Vol 44 (9) ◽  
pp. S49
Author(s):  
Eric Pietras ◽  
Cristina Mirantes-Barbeito ◽  
Sarah Fong ◽  
Dirk Loeffler ◽  
Larisa Kovtonyuk ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Fate ◽  
Hematopoietic Stem Cell ◽  
Inflammatory Cytokine ◽  
Interleukin 1 ◽  
Hematopoietic Stem ◽  
Stem Cell Fate ◽  
And Function

Metabolic Regulation of Stem Cell Fate and Function

2020 ◽  
Vol 34 (S1) ◽  
pp. 1-1
Author(s):  
Suzanne N. Shapira ◽  
Heather R. Christofk
Keyword(s):  
Stem Cell ◽  
Cell Fate ◽  
Metabolic Regulation ◽  
Stem Cell Fate ◽  
And Function

scholarly journals Functional nanoarrays for investigating stem cell fate and function

Nanoscale ◽  
2020 ◽  
Vol 12 (17) ◽  
pp. 9306-9326 ◽  
Author(s):  
Jin-Ho Lee ◽  
Jeffrey Luo ◽  
Hye Kyu Choi ◽  
Sy-Tsong Dean Chueng ◽  
Ki-Bum Lee ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Fate ◽  
Recent Progress ◽  
Live Cell ◽  
Stem Cell Fate ◽  
Cell Functions ◽  
And Function

An overview of the recent progress of nanoarray synthesis and applications for controlling stem cell fate and monitoring live cell functions.

Substrates and Surfaces for Control of Pluripotent Stem Cell Fate and Function

2016 ◽  
pp. 343-380 ◽  
Author(s):  
Akshaya Srinivasan ◽  
Yi-Chin Toh ◽  
Xian Jun Loh ◽  
Xian Jun Loh ◽  
Xian Jun Loh ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Fate ◽  
Pluripotent Stem Cell ◽  
Stem Cell Fate ◽  
And Function

scholarly journals Metabolic control of primed human pluripotent stem cell fate and function by the miR-200c–SIRT2 axis

2017 ◽  
Vol 19 (5) ◽  
pp. 445-456 ◽  
Author(s):  
Young Cha ◽  
Min-Joon Han ◽  
Hyuk-Jin Cha ◽  
Janet Zoldan ◽  
Alison Burkart ◽  
...  
Keyword(s):  
Stem Cell ◽  
Metabolic Control ◽  
Cell Fate ◽  
Pluripotent Stem Cell ◽  
Human Pluripotent Stem Cell ◽  
Stem Cell Fate ◽  
And Function
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