Nile Red Loaded PLGA Nanoparticles Surface Modified with Gd-DTPA for Potential Dual-Modal Imaging

2016 ◽  
Vol 16 (6) ◽  
pp. 5569-5576 ◽  
Author(s):  
Qinqin Li ◽  
Chenglin Li ◽  
Weijun Tong
Keyword(s):  
Nile Red ◽  
Plga Nanoparticles ◽  
Surface Modified

scholarly journals Chitosan Oleate Salt as an Amphiphilic Polymer for the Surface Modification of Poly-Lactic-Glycolic Acid (PLGA) Nanoparticles. Preliminary Studies of Mucoadhesion and Cell Interaction Properties

Marine Drugs ◽  
2018 ◽  
Vol 16 (11) ◽  
pp. 447 ◽  
Author(s):  
Dalila Miele ◽  
Silvia Rossi ◽  
Giuseppina Sandri ◽  
Barbara Vigani ◽  
Milena Sorrenti ◽  
...  
Keyword(s):  
Glycolic Acid ◽  
Membrane Surface ◽  
Nile Red ◽  
Surface Characteristics ◽  
Cell Interaction ◽  
Plga Nanoparticles ◽  
Expected Improvement ◽  
Surface Modified ◽  
Surface Modified Nanoparticles ◽  
First Time

Most of the methods of poly-lactic-glycolic acid (PLGA) preparation involve the passage through the emulsification of a PLGA organic solution in water followed by solvent evaporation or extraction. The choice of the droplet stabilizer during the emulsion step is critical for the dimensions and the surface characteristics of the nanoparticles (NPs). In the present work, a recently described ionic amphiphilic chitosan derivative, chitosan oleate salt (CS-OA), was proposed for the first time to prepare PLGA NPs. A full factorial design was used to understand the effect of some formulation and preparation parameters on the NP dimensions and on encapsulation efficiency (EE%) of Nile red, used as a tracer. On the basis of the DoE study, curcumin loaded NPs were prepared, having 329 ± 42 nm dimensions and 68.75% EE%. The presence of a chitosan coating at the surface was confirmed by positive zeta potential and resulted in mucoadhesion behavior. The expected improvement of the interaction of the chitosan surface modified nanoparticles with cell membrane surface was confirmed in Caco-2 cell culture by the internalization of the loaded curcumin.

Targeting cancer cells using PLGA nanoparticles surface modified with monoclonal antibody

2007 ◽  
Vol 120 (1-2) ◽  
pp. 18-26 ◽  
Author(s):  
Petra Kocbek ◽  
Nataša Obermajer ◽  
Mateja Cegnar ◽  
Janko Kos ◽  
Julijana Kristl
Keyword(s):  
Monoclonal Antibody ◽  
Cancer Cells ◽  
Plga Nanoparticles ◽  
Surface Modified

Paclitaxel-loaded PLGA nanoparticles surface modified with transferrin and Pluronic®P85, anin vitrocell line andin vivobiodistribution studies on rat model

2009 ◽  
Vol 17 (7) ◽  
pp. 533-542 ◽  
Author(s):  
Neha Shah ◽  
Kiran Chaudhari ◽  
Prudhviraju Dantuluri ◽  
R. S. R. Murthy ◽  
Susobhan Das
Keyword(s):  
Rat Model ◽  
Plga Nanoparticles ◽  
Surface Modified

scholarly journals Toxicity, pharmacokinetics, and in vivo efficacy of biotinylated chitosan surface-modified PLGA nanoparticles for tumor therapy

2016 ◽  
Vol 45 (6) ◽  
pp. 1115-1122 ◽  
Author(s):  
Hongli Chen ◽  
WenBin Nan ◽  
Xiangjuan Wei ◽  
Yan Wang ◽  
Feng Lv ◽  
...  
Keyword(s):  
Tumor Therapy ◽  
Plga Nanoparticles ◽  
In Vivo Efficacy ◽  
Surface Modified

Development and Validation of an HPLC Method for the Quantification of Morin Flavonoid Encapsulated within PLGA Nanoparticles.

2020 ◽  
Vol 16 ◽  
Author(s):  
Mario Alonso ◽  
Emilia Barcia ◽  
Manuel Córdoba-Díaz ◽  
Sofia Negro ◽  
Damián Córdoba-Díaz ◽  
...  
Keyword(s):  
Polymeric Nanoparticles ◽  
Plga Nanoparticles ◽  
Hplc Method ◽  
Water Soluble ◽  
Phe Phenylalanine ◽  
Neuroprotective Effects ◽  
Accuracy And Precision ◽  
Interesting Approach ◽  
Surface Modified ◽  
Development And Validation

Background: Morin flavonoid exerts neuroprotective effects with potential interest in neurodegenerative disorders. For this, the use of surface-modified polymeric nanoparticles loaded with morin is an interesting approach. Objective: To develop and validate an HPLC method for the quantification of morin released from a new delivery system consisting of poly lactic-co-glycolic (PLGA) nanoparticles functionalized with the dipeptide phe-phe (phenylalanine-phenylalanine) used to facilitate their access to the CNS. Method: The HPLC procedure was developed and validated with morin hydrate dissolved either in methanol (method A) or in methanol: 0.1N HCl (50:50, v/v, method B). Two new nanoparticle formulations were developed and characterized: morin-loaded PLGA nanoparticles (formulation F1), and morin-loaded PLGA phe-phe nanoparticles (formulation F2). Results: Method A was linear within the concentration range of 5-30 µg mL-1 and, 1-30 µg mL-1 for method B. LOD and LOQ with method A were 1.23 µg.mL-1 and 3.90 µg mL-1, respectively, and 0.481 µg.mL-1 and 1.458 µg mL-1 for method B. The average amount of phe-phe bound to formulation F2 (50 mg of NPs) was 431.33 µg. Encapsulation efficiency of morin within PLGA nanoparticles was around 80%. After functionalization this value decreased significantly. Conclusion: Method B showed better sensitivity, accuracy and precision for the quantification of morin. The procedure used to functionalize the nanoparticles was adequate for linking the dipeptide to their surfaces, but this procedure is not adequate when encapsulating water-soluble compounds.

Effect of vorinostat (V)-loaded PLGA nanoparticles (NP) surface modified with a PSMA ligand on prostate cancer (PC) cells.

2010 ◽  
Vol 28 (15_suppl) ◽  
pp. e13629-e13629
Author(s):  
C. J. Hoimes ◽  
R. P. Murelli ◽  
W. K. Kelly ◽  
A. X. Zhang ◽  
C. J. Cheng ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Plga Nanoparticles ◽  
Psma Ligand ◽  
Surface Modified

scholarly journals Clarithromycin-Loaded Poly (Lactic-co-glycolic Acid) (PLGA) Nanoparticles for Oral Administration: Effect of Polymer Molecular Weight and Surface Modification with Chitosan on Formulation, Nanoparticle Characterization and Antibacterial Effects

Polymers ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 1632 ◽  
Author(s):  
A. Alper Öztürk ◽  
Evrim Yenilmez ◽  
Mustafa Güçlü Özarda
Keyword(s):  
Oral Delivery ◽  
Glycolic Acid ◽  
In Vitro Release ◽  
Entrapment Efficiency ◽  
Plga Nanoparticles ◽  
Test Method ◽  
Molecular Weights ◽  
Antibiotic Group ◽  
Surface Modified

Clarithromycin (CLR) is a member of the macrolide antibiotic group. CLR has low systemic oral bioavailability and is a drug of class II of the Biopharmaceutical Classification System. In many studies, using nanoparticles (NPs) as a drug delivery system has been shown to increase the effectiveness and bioavailability of active drug substances. This study describes the development and evaluation of poly (lactic-co-glycolic acid) (PLGA) NPs and chitosan (CS)-coated PLGA NPs for oral delivery of CLR. NPs were obtained by nanoprecipitation technique and characterized in detail, and the effect of three molecular weights (Mw1: 7.000–17.000, Mw2: 38.000–54.000, Mw3: 50.000–190.000) of PLGA and CS coating on particle size (PS), zeta potential (ZP), entrapment efficiency (EE%), and release properties etc. were elucidated. Gastrointestinal stability and cryoprotectant effect tests were performed on the NPs. The PS of the prepared NPs were in the range of 178 to 578 nm and they were affected by the Mw and CS coating. In surface-modified formulations with CS, the ZP of the NPs increased significantly to positive values. EE% varied from 62% to 85%, depending upon the Mw and CS coating. In vitro release studies of CLR-loaded NPs showed an extended release up to 144 h. Peppas–Sahlin and Weibull kinetic model was found to fit best for CLR release from NPs. By the broth microdilution test method, the antibacterial activity of the formulations was determined on Staphylococcus aureus (ATCC 25923), Listeria monocytogenes (ATCC 1911), and Klebsiella pneumoniae (ATCC 700603). The structures of the formulations were clarified by thermal (DSC), FT-IR, and 1H-NMR analysis. The results showed that PS, ZP, EE%, and dissolution rates of NPs were directly related to the Mw of PLGA and CS coating.

Surface modified PLGA nanoparticles for brain targeting of Bacoside-A

2014 ◽  
Vol 63 ◽  
pp. 29-35 ◽  
Author(s):  
S. Jose ◽  
S. Sowmya ◽  
T.A. Cinu ◽  
N.A. Aleykutty ◽  
S. Thomas ◽  
...  
Keyword(s):  
Plga Nanoparticles ◽  
Brain Targeting ◽  
Bacoside A ◽  
Surface Modified
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