Surface modified PLGA nanoparticles for brain targeting of Bacoside-A

2014 ◽  
Vol 63 ◽  
pp. 29-35 ◽  
Author(s):  
S. Jose ◽  
S. Sowmya ◽  
T.A. Cinu ◽  
N.A. Aleykutty ◽  
S. Thomas ◽  
...  
Keyword(s):  
Plga Nanoparticles ◽  
Brain Targeting ◽  
Bacoside A ◽  
Surface Modified

Targeting cancer cells using PLGA nanoparticles surface modified with monoclonal antibody

2007 ◽  
Vol 120 (1-2) ◽  
pp. 18-26 ◽  
Author(s):  
Petra Kocbek ◽  
Nataša Obermajer ◽  
Mateja Cegnar ◽  
Janko Kos ◽  
Julijana Kristl
Keyword(s):  
Monoclonal Antibody ◽  
Cancer Cells ◽  
Plga Nanoparticles ◽  
Surface Modified

Paclitaxel-loaded PLGA nanoparticles surface modified with transferrin and Pluronic®P85, anin vitrocell line andin vivobiodistribution studies on rat model

2009 ◽  
Vol 17 (7) ◽  
pp. 533-542 ◽  
Author(s):  
Neha Shah ◽  
Kiran Chaudhari ◽  
Prudhviraju Dantuluri ◽  
R. S. R. Murthy ◽  
Susobhan Das
Keyword(s):  
Rat Model ◽  
Plga Nanoparticles ◽  
Surface Modified

scholarly journals Toxicity, pharmacokinetics, and in vivo efficacy of biotinylated chitosan surface-modified PLGA nanoparticles for tumor therapy

2016 ◽  
Vol 45 (6) ◽  
pp. 1115-1122 ◽  
Author(s):  
Hongli Chen ◽  
WenBin Nan ◽  
Xiangjuan Wei ◽  
Yan Wang ◽  
Feng Lv ◽  
...  
Keyword(s):  
Tumor Therapy ◽  
Plga Nanoparticles ◽  
In Vivo Efficacy ◽  
Surface Modified

PLGA nanoparticles for nose to brain delivery of Clonazepam: formulation, optimization by 32 Factorial design, in vitro and in vivo evaluation

2020 ◽  
Vol 17 ◽  
Author(s):  
Pranav Shah ◽  
Jayant Sarolia ◽  
Bhavin Vyas ◽  
Priti Wagh ◽  
Kaul Ankur ◽  
...  
Keyword(s):  
Particle Size ◽  
Factorial Design ◽  
Intranasal Administration ◽  
Plga Nanoparticles ◽  
Brain Targeting ◽  
Rabbit Brain ◽  
Histopathological Study ◽  
In Vivo Evaluation

Background: Intranasal administration of biodegradable nanoparticles has been extensively studied for targeting the drug directly to CNS through olfactory or trigeminal route bypassing blood brain barrier. Objective: The objective of the present study was to optimize Clonazepam loaded PLGA nanoparticles (CLO-PNPs) by investigating the effect of process variables on the responses using 32 full factorial design. Methods: Effect of two independent factors-amount of PLGA and concentration of Poloxamer 188, were studied at low, medium and high levels on three dependent responses-%Entrapment efficiency, Particle size (nm) and %cumulative drug release at 24hr. Results: %EE, Particle size and %CDR at 24hr of optimized batch was 63.7%, 165.1 nm and 86.96% respectively. Nanoparticles were radiolabeled with 99mTc and biodistribution was investigated in BALB/c mice after intranasal & intravenous administrations. Significantly higher brain/blood uptake ratios and AUC values in brain following intranasal administration of CLO-PNPs indicated more effective brain targeting of CLO. Higher brain uptake of intranasal CLO-PNPs was confirmed by rabbit brain scintigraphy imaging. Histopathological study performed on goat nasal mucosa revealed no adverse response of nanoparticles. TEM image exhibited spherical shaped particles in nano range. DSC and XRD studies suggested Clonazepam encapsulation within PLGA matrix. The onset of occurrence of PTZ-induced seizures in rats was significantly delayed by intranasal nanoparticles as compared to intranasal & intravenous CLO-SOL. Conclusion: This investigation exhibits rapid rate and higher extent of CLO transport in brain with intranasal CLO-PNPs suggesting a better option as compared to oral & parenteral route in management of acute status epilepticus.

Development and Validation of an HPLC Method for the Quantification of Morin Flavonoid Encapsulated within PLGA Nanoparticles.

2020 ◽  
Vol 16 ◽  
Author(s):  
Mario Alonso ◽  
Emilia Barcia ◽  
Manuel Córdoba-Díaz ◽  
Sofia Negro ◽  
Damián Córdoba-Díaz ◽  
...  
Keyword(s):  
Polymeric Nanoparticles ◽  
Plga Nanoparticles ◽  
Hplc Method ◽  
Water Soluble ◽  
Phe Phenylalanine ◽  
Neuroprotective Effects ◽  
Accuracy And Precision ◽  
Interesting Approach ◽  
Surface Modified ◽  
Development And Validation

Background: Morin flavonoid exerts neuroprotective effects with potential interest in neurodegenerative disorders. For this, the use of surface-modified polymeric nanoparticles loaded with morin is an interesting approach. Objective: To develop and validate an HPLC method for the quantification of morin released from a new delivery system consisting of poly lactic-co-glycolic (PLGA) nanoparticles functionalized with the dipeptide phe-phe (phenylalanine-phenylalanine) used to facilitate their access to the CNS. Method: The HPLC procedure was developed and validated with morin hydrate dissolved either in methanol (method A) or in methanol: 0.1N HCl (50:50, v/v, method B). Two new nanoparticle formulations were developed and characterized: morin-loaded PLGA nanoparticles (formulation F1), and morin-loaded PLGA phe-phe nanoparticles (formulation F2). Results: Method A was linear within the concentration range of 5-30 µg mL-1 and, 1-30 µg mL-1 for method B. LOD and LOQ with method A were 1.23 µg.mL-1 and 3.90 µg mL-1, respectively, and 0.481 µg.mL-1 and 1.458 µg mL-1 for method B. The average amount of phe-phe bound to formulation F2 (50 mg of NPs) was 431.33 µg. Encapsulation efficiency of morin within PLGA nanoparticles was around 80%. After functionalization this value decreased significantly. Conclusion: Method B showed better sensitivity, accuracy and precision for the quantification of morin. The procedure used to functionalize the nanoparticles was adequate for linking the dipeptide to their surfaces, but this procedure is not adequate when encapsulating water-soluble compounds.

Effect of vorinostat (V)-loaded PLGA nanoparticles (NP) surface modified with a PSMA ligand on prostate cancer (PC) cells.

2010 ◽  
Vol 28 (15_suppl) ◽  
pp. e13629-e13629
Author(s):  
C. J. Hoimes ◽  
R. P. Murelli ◽  
W. K. Kelly ◽  
A. X. Zhang ◽  
C. J. Cheng ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Plga Nanoparticles ◽  
Psma Ligand ◽  
Surface Modified
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