scholarly journals Controlled Release Compound Based on Metanilate-Layered Double Hydroxide Nanohybrid

2008 ◽  
Vol 8 (11) ◽  
pp. 5921-5928 ◽  
Author(s):  
Mohd Zobir Hussein ◽  
Norashikin Mat Nasir ◽  
Asmah Hj Yahaya
Keyword(s):  
Controlled Release ◽  
Layered Double Hydroxide ◽  
Mother Liquor ◽  
Organic Anion ◽  
Active Agent ◽  
Metal Cations ◽  
The Other ◽  
Precipitation Method ◽  
Order Kinetic ◽  
Double Hydroxide

Metanilate-layered double hydroxide nanohybrid compound was synthesized for controlled release purposes through co-precipitation method of the metal cations and organic anion. The effect of various divalent metal cations (M2+), namely Zn2+, Mg2+ and Ca2+ on the formation of metanilate-LDH nanohybrids, in which metanilate anion was intercalated into three different layered double hydroxide (LDH) systems; Zn-Al, Mg-Al and Ca-Al were investigated. The syntheses were carried out with M2+ to Al3+ initial molar ratio, R of 4. The pH of the mother liquor was maintained at pH 7.5 and 10 during the synthesis, and the resulting mixture was aged at around 70 °C for about 18 h. The intercalation of metanilate anion into the host was found to be strongly influenced by the M2+ that formed the inorganic metal hydroxide layers. Under our experimental condition, the formation of the nanohybrid materials was found to be more feasible for the Zn-Al than for the other two systems, in which the former showed well-ordered layered organic–inorganic nanohybrid structure with good crystallinity. Intercalation is confirmed by the expansion of the interlayer spacing to about 15–17 Å when metanilate was introduced into the interlamellae of Zn-Al LDHs. In addition, CHNS and FTIR analyses also support that metanilate anion has been successfully intercalated into the interlamellae of the inorganic LDH. Apart from M2+, this study also shows that the initial pH of the mother liquor plays an important role in determining the physicochemical properties of the resulting nanohybrids, especially the mole fraction of the Zn2+ substituted by the Al3+ ion in the LDH inorganic sheets which in turn controlled the loading percentage of the organic anion, surface properties and the true density. Preliminary study shows that LDH can be used to host beneficial guests, active agent with controlled release capability of the guests. Generally the overall process is governed by pseudo second order kinetic but for the first 180 min, the release process can be slightly better described by parabolic diffusion than the other models.

scholarly journals Synthesis and Cytotoxicity Study of Magnetite Nanoparticles Coated with Polyethylene Glycol and Sorafenib–Zinc/Aluminium Layered Double Hydroxide

Polymers ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 2716
Author(s):  
Mona Ebadi ◽  
Kalaivani Buskaran ◽  
Saifullah Bullo ◽  
Mohd Zobir Hussein ◽  
Sharida Fakurazi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Polyethylene Glycol ◽  
Layered Double Hydroxide ◽  
Average Particle Size ◽  
Superparamagnetic Iron Oxide ◽  
Precipitation Method ◽  
Average Particle ◽  
Order Kinetic ◽  
Number Of Patients ◽  
Double Hydroxide

In the last two decades, the development of novel approaches for cancer treatment has attracted intense attention due to the growing number of patients and the inefficiency of the available current conventional treatments. In this study, superparamagnetic iron oxide nanoparticles (SPIONs) were synthesized by the co-precipitation method in an alkaline medium. Then the nanoparticles were chemically modified by coating them with polyethylene glycol (PEG) and sorafenib (SO)–zinc/aluminum layered double hydroxide (ZLDH) to improve their biocompatibility. The SPIONs and their coated and drug-loaded nanoparticles, M-PEG–SO–ZLDH are of the crystalline phase with the presence of C, O, Al, Fe, Cl, Zn in the latter, indicating the presence of the coating layers on the surface of the SPIONs. The superparamagnetic properties of the bare SPIONs were found to be reduced but retained in its coated drug delivery nanoparticles, M-PEG–SO–ZLDH. The latter has an average particle size of 16 nm and the release of the drug from it was found to be governed by the pseudo-second-order kinetic. The cytotoxicity and biocompatibility evaluation of the drug-loaded magnetic nanoparticles using 3T3 and HepG2 cells using the diphenyltetrazolium bromide (MTT) assays shows that the synthesized nanoparticles were less toxic than the pure drug. This preliminary study indicates that the prepared nanoparticles are suitable to be used for the drug delivery system.

Inorganic layered double hydroxides as a 4-hexyl resorcinol delivery system for topical applications

RSC Advances ◽  
2016 ◽  
Vol 6 (81) ◽  
pp. 77709-77716 ◽  
Author(s):  
Damodar Mosangi ◽  
Sreejarani Kesavan Pillai ◽  
Lumbidzani Moyo ◽  
Suprakas Sinha Ray
Keyword(s):  
Controlled Release ◽  
Layered Double Hydroxide ◽  
Delivery System ◽  
Layered Double Hydroxides ◽  
Skin Tone ◽  
Precipitation Method ◽  
Co Precipitation ◽  
Double Hydroxide ◽  
Double Hydroxides ◽  
Topical Applications

In this study, the hydrophobic even skin tone active, 4-hexylresorcinol is intercalated into a Zn–Al layered double hydroxide by co-precipitation method and used as controlled release ingredient in a skin care formulation.

Influence of Metal Cations on the Structure and Release Property of Layered Double Hydroxide-Ibuprofen Host-Guest Materials

2010 ◽  
Vol 152-153 ◽  
pp. 556-559 ◽  
Author(s):  
Peng Ding ◽  
Sheng Fu Tang ◽  
Zong Zhou Li
Keyword(s):  
Controlled Release ◽  
Drug Release ◽  
Layered Double Hydroxide ◽  
Great Influence ◽  
Metal Cations ◽  
Coprecipitation Method ◽  
Drug Controlled Release ◽  
Release Property ◽  
Double Hydroxide

Layered double hydroxide (LDH)-ibuprofen (IBU) host-guest materials were prepared by in situ coprecipitation method for the purpose of drug controlled release. Three hosts containing different metal cations, MgAl-, ZnAl-, and MgFe-LDH, were studied. The results showed that the types of the metal cations had great influence on the structures of the host-guest materials and thus led to different drug release properities.

Hierarchical coated metal hydroxide nanoconstructs as potential controlled release carriers of photosensitizer for skin melanoma

RSC Advances ◽  
2015 ◽  
Vol 5 (53) ◽  
pp. 42666-42680 ◽  
Author(s):  
Ranjith Kumar Kankala ◽  
Yaswanth Kuthati ◽  
Chen-Lun Liu ◽  
Chia-Hung Lee
Keyword(s):  
Controlled Release ◽  
Layered Double Hydroxide ◽  
Metal Hydroxide ◽  
Skin Melanoma ◽  
Anionic Clay ◽  
Coated Metal ◽  
Clay Matrix ◽  
Double Hydroxide

Inorganic nanostructured ensembles containing an anionic clay matrix with layered double hydroxide (LDH) were designed in nanooncology for photosensitizer delivery.

An elegant synthesis of chitosan grafted hydrotalcite nano-bio composite material and its effective catalysis for solvent-free synthesis of jasminaldehyde

RSC Advances ◽  
2015 ◽  
Vol 5 (115) ◽  
pp. 94562-94570 ◽  
Author(s):  
Jacky H. Adwani ◽  
Noor-ul H. Khan ◽  
Ram S. Shukla
Keyword(s):  
Composite Material ◽  
Layered Double Hydroxide ◽  
Solvent Free ◽  
Precipitation Method ◽  
Co Precipitation ◽  
Double Hydroxide ◽  
Solvent Free Synthesis

A novel nano-bio composite of chitosan and a layered double hydroxide elegantly synthesized by a co-precipitation method had effectively and selectively catalysed the jasminaldehyde synthesis.

Highly efficient carbonaceous nanofiber/layered double hydroxide nanocomposites for removal of U(VI) from aqueous solutions

2019 ◽  
Vol 107 (4) ◽  
pp. 299-309
Author(s):  
Shuqi Yu ◽  
Xiangxue Wang ◽  
Shunyan Ning ◽  
Zhongshan Chen ◽  
Xiangke Wang
Keyword(s):  
Ionic Strength ◽  
Aqueous Solutions ◽  
Layered Double Hydroxide ◽  
Photoelectron Spectroscopy ◽  
Environmental Remediation ◽  
Three Dimensional ◽  
Order Kinetic ◽  
Surface Bonding ◽  
Double Hydroxide ◽  
Shed Light

Abstract The three-dimensional (3D) carbonaceous nanofiber and Ni-Al layered double hydroxide (CNF/LDH) nanocomposite was successfully prepared by a facile one-step hydrothermal methodology. Characterization of scanning electron microscope (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), XRD, and Fourier transformed infrared spectroscopy (FTIR) provided a demonstration that the modified CNF/LDH nanocomposite possessed abundant functional groups, for instance, metal-oxygen surface bonding sites (Ni–O as well as Al–O) and free-metal surface bonding sites (C–O, C–O–C, as well as O–C=O). The elimination of representative radionuclide (i.e. U(VI)) on the CNF/LDH nanocomposite from aqueous solutions was explored as a key function of pH, ionic strength, contact time, reaction temperature as well as radionuclide preliminary concentrations with the use of the batch methodology. As revealed by the findings, the sorption of radionuclides on CNF/LDH nanocomposite adhered to the pseudo-second-order kinetic model as well as Langmuir model. The maximum elimination capacity of U(VI) amounted to be 0.7 mmol/g. The independent of ionic strength shed light on the fact that inner-sphere surface complexation mainly overpowered radionuclide uptake by the CNF/LDH nanocomposite, which was further verified through the combination of FTIR and XPS spectral analyses. The abovementioned analyses shed light on the fact that the CNF/LDH nanocomposite can be regarded as a latent material to preconcentration radionuclides for environmental remediation.

Herbicide/Zn-Al-layered double hydroxide hybrid composite: synthesis and slow/controlled release properties

2017 ◽  
Vol 24 (23) ◽  
pp. 19386-19392 ◽  
Author(s):  
Nguyen Thi Kim Phuong ◽  
Ho Nguyen Nhat Ha ◽  
Nguyen Thi Phuong Dieu ◽  
Bui The Huy
Keyword(s):  
Controlled Release ◽  
Layered Double Hydroxide ◽  
Hybrid Composite ◽  
Double Hydroxide ◽  
Composite Synthesis
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