Mixed Micelle-Template Route to Mesoporous Silica

2007 ◽  
Vol 7 (11) ◽  
pp. 3819-3822 ◽  
Author(s):  
You-Hwan Son ◽  
Man Park ◽  
Sang Tae Kim ◽  
Jin-Ho Choy
Keyword(s):  
Mesoporous Silica ◽  
Polyethylene Oxide ◽  
Mixed Micelle ◽  
Weight Ratio ◽  
Mesoporous Structure ◽  
X Ray Diffraction ◽  
X Ray ◽  
Diffraction Patterns ◽  
Mcf 7

Mesoporous silica materials were prepared through a novel mixed micelle-template method which was employed by alkyl polyethylene oxide (C16E20 and C2-ceramide. X-ray diffraction patterns clearly showed the formation of mesoporous silica by contribution of mixed micelle-template up to 3/1 weight ratio (C16E20/C2-ceramide). TEM and N2 adsorption isotherms analyses indicated that the mesoporous structure was maintained even after encased C2-ceramides. However, when the weight ratio of C16E20/C2-ceramide exceeds 2/2, less ordered and irregular pore structure was observed. According to the in-vitro experiment on cancer cells such as MCF-7, HOS, and HepG2, the simultaneously encapsulated C2-ceramide shows apoptosis. Therefore, the present results could provide a new method for mesoporous material as drug delivery system.

scholarly journals Curcumin-Loaded Mixed Micelles: Preparation, Characterization, and In Vitro Antitumor Activity

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Suping Ji ◽  
Xiao Lin ◽  
Enjiang Yu ◽  
Chengyang Dian ◽  
Xiong Yan ◽  
...  
Keyword(s):  
Mixed Micelles ◽  
Drug Loading ◽  
Molecular State ◽  
X Ray Diffraction ◽  
X Ray ◽  
Release Property ◽  
Mean Size ◽  
Xrd Patterns ◽  
Mcf 7

The objective of this study was to prepare curcumin-loaded mixed Soluplus/TPGS micelles (Cur-TPGS-PMs) for oral administration. The Cur-TPGS-PMs showed a mean size of 65.54 ± 2.57 nm, drug encapsulation efficiency over 85%, and drug loading of 8.17%. The Cur-TPGS-PMs were found to be stable in various pH media (pH 1.2 for 2 h, pH 6.8 for 2 h, and pH 7.4 for 6 h). The X-ray diffraction (XRD) patterns illustrated that curcumin was in the amorphous or molecular state within PMs. The In vitro release test indicated that Cur-TPGS-PMs possessed a significant sustained-release property. The cell viability in MCF-7 cells was found to be relatively lower in Cur-TPGS-PM-treated cells as compared to free Cur-treated cells. CLSM imaging revealed that mixed micelles were efficiently absorbed into the cytoplasm region of MCF-7 cells. Therefore, Cur-TPGS-PMs could have the significant value for the chronic breast cancer therapy.

Reactions of 2-cyano-3-ferrocenylacrylonitrile with malononitrile: formation of 4-ferrocenylpyridine-3,5-dicarbonitrile derivatives and sodium polymeric complexes containing carbanionic ligands

2014 ◽  
Vol 86 (11) ◽  
pp. 1839-1852 ◽  
Author(s):  
Elena Ivanovna Klimova ◽  
Marcos Martínez García ◽  
Jessica Jazmin Sánchez García ◽  
Teresa Ramírez Apan ◽  
Andrei V. Churakov ◽  
...  
Keyword(s):  
Human Tumor ◽  
Tumor Cell Lines ◽  
X Ray Diffraction ◽  
Human Tumor Cell ◽  
Human Tumor Cell Lines ◽  
X Ray ◽  
Biological Specificity ◽  
Polymeric Complexes ◽  
Mcf 7

Abstract The reactions of 2-cyano-3-ferrocenylacrylonitrile with malononitrile in a EtOH/H2O or MeOH/H2O medium in the presence of Na2CO3 afforded 6-alkoxy-2-amino-4-ferrocenylpyridine-3,5-dicarbonitriles 3a,b (multi-component condensation), 6-alkoxy-2-amino-4-ferrocenyl-3-ferrocenylmethyl-3,4-dihydropyridine-3,5-dicarbonitriles 4a,b (multi-component cyclodimerization) and Na+ polymeric complexes: {[Na+(2-ferrocenyl(tetracyano)propenyl)–L]∞5a,b and [Na+(2-amino-3,5-dicyano-4-ferrocenyl-6-pyridyl-dicyanomethyl)–L]∞6a,b, where L = ethanol, methanol. Complexes with L = acetonitrile, dimethylformamide, acetone, ethyl acetate were prepared by recrystallization. The structures of the compounds 3b, 4b and Na+ polymeric complexes were established by the spectroscopic data and X-ray diffraction analysis. Two compounds 3a and 4a were tested in vitro against six human tumor cell lines U-251, PC-3, K-562, HCT-15, MCF-7 and SKLU-1 to assess their in vitro antitumor activity. The results suggest biological specificity towards PC-3, K-562 and HCT-15 cells for compound 3a, and towards PC-3 cell for compound 4a at doses of 50 μM, which are lower than cis-platin.

Studies of Cell Growth on TiO2 Nanotubes

2012 ◽  
Vol 620 ◽  
pp. 325-329 ◽  
Author(s):  
Nur Hidayati Ahmad Barudin ◽  
Srimala Sreekantan ◽  
Ong Ming Thong ◽  
Lam Kit Lay
Keyword(s):  
Cancer Cell Line ◽  
Cellular Responses ◽  
Cell Interaction ◽  
Electrochemical Anodization ◽  
X Ray Diffraction ◽  
Cell Adherence ◽  
Anodization Voltage ◽  
X Ray ◽  
Mcf 7

The in vitro cell response was investigated on flat Ti surface vs nanostructured TiO2 nanotube surface. The titanium dioxide nanotube layers were prepared by electrochemical anodization of Ti in ethylene glycol, 5 wt% NH4F and 1ml H2O2. The nanotube layered structure and morphology were characterized using X-ray diffraction (XRD) and field emission scanning electron microscopy (FESEM). The diameter and the length of the nanotubes are found to increase with anodization voltage. Hs27 and breast cancer cell line MCF-7 were used for cell interaction studies. Different surfaces of titanium show variation in term of growth and viability of cells. Different cell type also show different cellular responses to these surfaces. Titanium nanotube with tube diameter 90 nm promoted normal cell adherence and spreading but killed the cancer cells. The detail of the observation is discussed thoroughly in this paper.

scholarly journals Fabrication of bionanocomposite based on LDH using biopolymer of gum arabic and chitosan-coating for sustained drug-release

2020 ◽  
Vol 85 (9) ◽  
pp. 1223-1235 ◽  
Author(s):  
Milad Abniki ◽  
Ali Moghimi ◽  
Fariborz Azizinejad
Keyword(s):  
Drug Release ◽  
Gum Arabic ◽  
X Ray Diffraction ◽  
Sustained Drug Release ◽  
Experimental Conditions ◽  
X Ray ◽  
Model Drug ◽  
Diffraction Patterns ◽  
New Formulation

The study proposed a new formulation to the sustained delivery of mefenamate anions intercalated into Mg?Al layered double hydroxide (LDH) for oral administration. Different experimental conditions were evaluated to incorporate the mefenamic acid (MEF) and gum arabic (GUM) into LDH structure. The LDH?MEF and LDH?MEF/GUM were covered with chitosan (CHIT). In another experiment, LDH?Cl was used to adsorb mefenamate anions and evaluate the mechanism. The products of LDH were characterized by using different techniques such as FESEM (field emission scanning electron microscopy), XRD (X-ray diffraction), FTIR (Fourier transform infrared) spectroscopy and TGA (thermogravimetric analysis). The X-ray diffraction patterns and FTIR analyses confirmed that the MEF and GUM were successfully intercalated into the interlayer space of LDH. TG analysis verified that the thermal stability of intercalated MEF in the form of bionanocomposite (LDH?MEF/ /GUM/CHIT) was enhanced. Finally, In vitro drug release experiments of bionanocomposite at a pH of 1.2 (acidic medium) and a pH of 7.4 (phosphate buffer medium) showed sustained release profiles with mefenamate anions as an anti-inflammatory model drug.

In Vitro Growth of Aragonite Crystal on Nacre Surface

2007 ◽  
Vol 330-332 ◽  
pp. 1335-1338 ◽  
Author(s):  
Cheng Luo ◽  
Lei Xie ◽  
Xiao Xiang Wang
Keyword(s):  
Calcium Carbonate ◽  
Deposition Time ◽  
Early Stage ◽  
Diffusion Method ◽  
In Vitro Growth ◽  
X Ray Diffraction ◽  
X Ray ◽  
Aragonite Crystal ◽  
Diffraction Patterns

In an effort to investigate the growth mechanism of nacre, a conventional vapor diffusion method for CaCO3 crystal precipitation was applied to in vitro growth of calcium carbonate on freshwater H. cumingii Lea shell. In a 10mM/L CaCl2 solution without any additives, aragonite deposit was obtained on the nacre surface, specifically at the edges of nacreous tablets. At the early stage of the deposition (up to 4 hr), the deposit did not take any specific form. After 12hr of deposition, the deposit exhibited faceted morphology characteristic of crystalline. Further increasing the deposition time resulted in the formation of well-faceted crystals of tower-like shape. Both Raman spectra and X-ray diffraction patterns showed that the deposit consists of aragonite polymorph of calcium carbonate.

scholarly journals Tersone A-G, New Pyridone Alkaloids from the Deep-Sea Fungus Phomopsis tersa

Marine Drugs ◽  
2019 ◽  
Vol 17 (7) ◽  
pp. 394 ◽  
Author(s):  
Shan-Chong Chen ◽  
Zhao-Ming Liu ◽  
Hai-Bo Tan ◽  
Yu-Chan Chen ◽  
Sai-Ni Li ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
A549 Cell ◽  
Deep Sea ◽  
X Ray Diffraction ◽  
X Ray ◽  
Spectroscopic Analyses ◽  
Ic50 Values ◽  
Mic Value ◽  
Mcf 7

Four phenylfuropyridone racemates, (±)-tersones A-C and E (1–3, 5), one phenylpyridone racemate, (±)-tersone D (4), one new pyridine alkaloid, tersone F (6), single new phenylfuropyridone, tersone G (7) and two known analogs 8 and 9 were isolated from the deep-sea fungus Phomopsis tersa. Their structures and absolute configurations were characterized on the basis of comprehensive spectroscopic analyses, single-crystal X-ray diffraction experiments, and electronic circular dichroism (ECD) calculations. Moreover, compounds 1–9 were evaluated for in vitro antimicrobial and cytotoxic activity. Compounds 5b and 8b exhibited antibacterial activity against S. aureus with the MIC value of 31.5 μg/mL, while compound 5b showed cytoxic activities against SF-268, MCF-7, HepG-2 and A549 cell lines with IC50 values of 32.0, 29.5, 39.5 and 33.2 μM, respectively.

scholarly journals Enhanced Multiferroic Properties of YFeO3 by Doping with Bi3+

Materials ◽  
2019 ◽  
Vol 12 (13) ◽  
pp. 2054 ◽  
Author(s):  
Omar Rosales-González ◽  
Félix Sánchez-De Jesús ◽  
Fernando Pedro-García ◽  
Claudia Alicia Cortés-Escobedo ◽  
Màrius Ramírez-Cardona ◽  
...  
Keyword(s):  
Weight Ratio ◽  
High Energy ◽  
X Ray Diffraction ◽  
X Ray ◽  
Yttrium Orthoferrite ◽  
Cationic Substitution ◽  
Energy Ball ◽  
Diffraction Patterns ◽  
Magnetic Dielectric ◽  
Good Agreement

Tthe present work studied the cationic substitution of Y3+ by Bi3+ on the crystal structure of orthorhombic YFeO3 and its effect over magnetic, dielectric and electric properties of multiferroic yttrium orthoferrite. Stoichiometric mixtures of Y2O3, Fe2O3 and Bi2O3 were mixed and milled for 5 h using a ball to powder weight ratio of 10:1 by high-energy ball milling. The obtained powders were pressed at 1500 MPa and sintered at 700 °C for 2 h. The test samples were characterized at room temperature by X-ray diffraction (XRD), vibrating sample magnetometer (VSM), scanning electron microscope (SEM), energy dispersive X-ray spectroscopy (EDS) and impedance spectroscopy (IS). The X-ray diffraction patterns disclosed a maximum solubility of 30 % mol. of Bi3+ into the orthorhombic YFeO3. For higher concentrations, a transformation from orthorhombic to garnet structure was produced, obtaining partially Y3Fe5O12 phase. The substitution of Bi3+ in Y3+ sites promoted a distortion into the orthorhombic structure and modified Fe-O-Fe angles and octahedral tilt. In addition, it promoted a ferromagnetic (FM) order, which was attributed to both the crystal distortion and Dzyaloshinskii-Moriya interaction. For doped samples, an increase in real permittivity values was observed, and reduced with the increase of frequency. This in good agreement with the Maxwell-Wagner effect.

scholarly journals Physicochemical and in vitro bioactivity studies of bioactive glasses in the SiO2-CaO-MgO-P2O5, SiO2-Na2O-CaO-P2O5 and SiO2-Na2O-CaO-MgO-P2O5 systems

2020 ◽  
Vol 10 (5) ◽  
pp. 492
Author(s):  
Smaiel Herradi ◽  
Sara Bouhazma ◽  
Sanae Chajri ◽  
Imane Adouar ◽  
Souad Rakib ◽  
...  
Keyword(s):  
Dissolution Rate ◽  
Sol Gel ◽  
Energy Dispersive ◽  
In Vitro Test ◽  
X Ray Diffraction ◽  
X Ray ◽  
Vitro Test ◽  
Diffraction Patterns ◽  
The One

<p>Glasses in the quaternary and quinary system SiO<sub>2</sub>-CaO-MgO-P<sub>2</sub>O<sub>5 </sub>(SCMP), SiO<sub>2</sub>-Na<sub>2</sub>O-CaO-P<sub>2</sub>O<sub>5 </sub>(SNCP) and SiO<sub>2-</sub>Na<sub>2</sub>O-CaO-MgO-P<sub>2</sub>O<sub>5 </sub>(SNCMP), have been prepared by using the sol-gel technique. Investigations of structural and bioactive properties of these glasses have been undertaken by using X-ray diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM) and Energy Dispersive X-ray Spectroscopy (EDS). The <em>in vitro</em> bioactivity was assessed by determining the changes in surface morphology and composition after soaking in simulated body fluid (SBF) for up to 30 days at 37°C. X-ray diffraction patterns indicated the formation of hydroxycarbonated apatite layer (HCA) after only one hour for SNCMP glass and after four days for SCMP and SNCP glasses. Furthermore, observed bands of FTIR spectra confirmed the growth of HCA layer during in vitro test.</p><p>Moreover, the dissolution rate has been investigated using energy-dispersive X-ray spectroscopy. The observed EDS patterns confirmed the growth of HCA layer on all samples surfaces during <em>in vitro</em> analysis. On the one hand, we report the existence of Na<sub>2</sub>Ca<sub>2</sub>Si<sub>3</sub>O<sub>9 </sub>(that couple good mechanical strength with satisfactory biodegradability) as a single crystalline phase in the SNCP glass when calcined at 600°C. On the other hand, we have noticed that the coexistence of magnesium and sodium both enhanced the dissolution rate and hindered the crystallization in the SNCMP glass at 600°C.</p>

scholarly journals In Vitro Cytotoxicity and Morphological Assessments of GO-ZnO against the MCF-7 Cells: Determination of Singlet Oxygen by Chemical Trapping

Nanomaterials ◽  
2018 ◽  
Vol 8 (7) ◽  
pp. 539 ◽  
Author(s):  
Fozia Shaheen ◽  
Muhammad Aziz ◽  
Mahvish Fatima ◽  
Muhammad Khan ◽  
Faisal Ahmed ◽  
...  
Keyword(s):  
Chemical Properties ◽  
In Vitro Cytotoxicity ◽  
Dependent Manner ◽  
X Ray Diffraction ◽  
X Ray ◽  
Vis Spectroscopy ◽  
Potential Applicability ◽  
Mcf 7

Graphene-based materials have attracted considerable interest owing to their distinctive characteristics, such as their biocompatibility in terms of both their physical and intrinsic chemical properties. The use of nanomaterials with graphene as a biocompatible agent has increased due to an uptick in dedication from biomedical investigators. Here, GO-ZnO was characterized by X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), ultraviolet-visible (UV-Vis) spectroscopy, energy dispersive X-ray analysis (EDAX), and Raman spectroscopy for structural, morphological, and elemental analysis. The toxic extent of GO-ZnO was noted by a methyl-thiazole-tetrazolium (MTT), while cellular morphology was observed towards the MCF-7 cells using an inverted microscope at magnification 40×. The cytotoxic effect of GO-ZnO investigated the cell viability reduction in a dose-dependent manner, as well as prompted the cell demise/destruction in an apoptotic way. Moreover, statistical analysis was performed on the experimental outcomes, with p-values < 0.05 kept as significant to elucidate the results. The generation of reactive oxygen species (ROS) demonstrated the potential applicability of graphene in tumor treatment. These key results attest to the efficacy of GO-ZnO nanocomposites as a substantial candidate for breast malignancy treatment.

scholarly journals Mixed natural arylolefin–quinoline platinum(II) complexes: synthesis, structural characterization and in vitro cytotoxicity studies

2018 ◽  
Vol 74 (12) ◽  
pp. 1732-1743
Author(s):  
Nguyen Thi Thanh Chi ◽  
Pham Van Thong ◽  
Truong Thi Cam Mai ◽  
Luc Van Meervelt
Keyword(s):  
Double Bond ◽  
Cytotoxic Effect ◽  
In Vitro Cytotoxicity ◽  
Quinoline Derivative ◽  
X Ray Diffraction ◽  
Hep G2 ◽  
X Ray ◽  
Cytotoxicity Studies ◽  
Mcf 7

Five new platinum(II) complexes bearing a eugenol and a quinoline derivative, namely [η2-4-allyl-2-methoxy-1-(propoxycarbonylmethoxy)benzene]-trans-dichlorido(quinoline-κN)platinum(II), [PtCl2(C15H20O4)(C9H7N)], (2), {η2-4-allyl-2-methoxy-1-[(propan-2-yloxy)carbonylmethoxy]benzene}-trans-dichlorido(quinoline-κN)platinum(II), [PtCl2(C15H19O4)(C9H7N)], (3), [η2-4-allyl-2-methoxy-1-(propoxycarbonylmethoxy)benzene]chlorido(quinolin-8-olato-κ2 N,O)platinum(II), [Pt(C9H6NO)Cl(C15H20O4)], (4), {η2-4-allyl-2-methoxy-1-[(propan-2-yloxy)carbonylmethoxy]benzene}chlorido(quinolin-8-olato-κ2 N,O)platinum(II), [Pt(C9H6NO)Cl(C15H20O4)], (5), and [η2-4-allyl-2-methoxy-1-(propoxycarbonylmethoxy)benzene]chlorido(quinolin-2-carboxylato-κ2 N,O)platinum(II), [Pt(C10H6NO2)Cl(C15H20O4)], (6), have been synthesized and fully characterized spectroscopically. A single-crystal X-ray diffraction study was carried out for complexes (2) and (4)–(6). PrEug [or 4-allyl-2-methoxy-1-(propoxycarbonylmethoxy)benzene] in (2), (4) and (6), and iPrEug (the propan-2-yloxy analogue of PrEug) in (3) and (5) coordinate with PtII at the ethylenic double bond of the allyl group. In (2)–(6), the donor N atom of the amine group occupies a trans position with respect to the double bond. A comparison of the IC50 values of 0.38–29.23 µM for (2)–(6) with cisplatin, as well as other platinum(II) complexes, indicates an excellent in vitro cytotoxicity against the KB, LU, Hep-G2 and MCF-7 cancer cell lines, with the highest cytotoxic effect (IC50 = 0.38–1.99 µM) being for complexes (4) and (5) bearing a quinolin-8-olate ligand.

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