pH-Sensitive Eudragit S-100 Coated Chitosan Nanoparticles of 5-Amino Salicylic Acid for Colon Delivery

2014 ◽  
Vol 4 (9) ◽  
pp. 738-743 ◽  
Author(s):  
Pooja Mongia ◽  
Renuka Khatik ◽  
Rakesh Raj ◽  
Nidhi Jain ◽  
A. K. Pathak
Keyword(s):  
Salicylic Acid ◽  
Chitosan Nanoparticles ◽  
Ph Sensitive ◽  
Colon Delivery ◽  
S 100 ◽  
Amino Salicylic Acid ◽  
Eudragit S 100

scholarly journals Design, Development, and Optimization of Polymeric Based-Colonic Drug Delivery System of Naproxen

2013 ◽  
Vol 2013 ◽  
pp. 1-12 ◽  
Author(s):  
Pooja Sharma ◽  
Anuj Chawla ◽  
Pravin Pawar
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Ph Sensitive ◽  
Time Dependent ◽  
Wet Granulation ◽  
Design Development ◽  
Caecal Content ◽  
S 100 ◽  
Eudragit S 100

The aim of present investigation deals with the development of time-dependent and pH sensitive press-coated tablets for colon specific drug delivery of naproxen. The core tablets were prepared by wet granulation method then press coated with hydroxypropyl cellulose (HPC) or Eudragit RSPO : RLPO mixture and further coated with Eudragit S-100 by dip immerse method. Thein vitrodrug release study was conducted in different dissolution media such as pH 1.2, 6.8, and 7.4 with or without rat caecal content to simulate GIT conditions. Surface morphology and cross-sectional view of the tablets were visualized by scanning electron microscopy (SEM). All prepared batches were in compliance with the pharmacopoeial standards. The tablets which are compression coated with HPC followed by Eudragit S-100 coated showed highestin vitrodrug release of 98.10% in presence of rat caecal content. The SEM of tablets suggested that the number of pores got increased in pH 7.4 medium followed by dissolution of coating layer. The tablets coat erosion study suggested that the lag time depends upon the coating concentrations of polymers. A time-dependent hydrophilic polymer and pH sensitive polymer based press-coated tablets of naproxen were promising delivery for colon targeting.

Synthesis and Characterization of New Zinc Phthalocyanine - Dodecenyl Succinic Anhydride Benzoic Groups

2020 ◽  
Vol 17 (6) ◽  
pp. 488-495
Author(s):  
Hussein Ali Al-Bahrani ◽  
Mohanad Mousa Kareem ◽  
Abdul Amir Kadhum ◽  
Nour A. Alrazzak
Keyword(s):  
Salicylic Acid ◽  
Succinic Anhydride ◽  
Zinc Phthalocyanine ◽  
Central Metal ◽  
Target Compound ◽  
Compound I ◽  
Metal Phthalocyanines ◽  
Metal Atoms ◽  
Amino Salicylic Acid

Background: The phthalocyanines a series of compounds involves four iso-indole units linked by aza nitrogen atoms bonded with metal atoms that are normally located in the center a phthalocyanines ring. Some of the central metal-phthalocyanines can be excited by ultraviolet light and emit a fluorescence in far-red region. Objective: To synthesize a derivative of phthalocyanines namely 4,4',4' '-tri-(dodecenyl succinic anhydride)- 4' ' '-(5-amino salicylic acid) zinc phthalocyanine with a zinc central metal. Materials and Methods: The reaction of 4- nitro Phthalonitrile and 4- amino Phthalonitrile with ZnCl2 in the presence of dimethyl amino ethanol afforded 4,4',4' '-triamino-4' ' '-nitro zinc phthalocyanine. This product reacted with 5-amino salicylic acid to yield tetra-(5-amino salicylic acid) zinc phthalocyanine. A dodecenyl succinic anhydride was added on the amine group of benzoic rings to afford 4,4',4' '-tri-(dodecenyl succinic anhydride)-4' ' '-(5-amino salicylic acid) zinc phthalocyanine(I), the target compound. Results and Discussion: Compound I is successfully synthesized with a yield of 72% from tetra-(5-amino salicylic acid) zinc phthalocyanine with dodecenyl succinic anhydride. Conclusion: The newly synthesized molecule of 4,4',4' '-tri-(dodecenyl succinic anhydride)-4' ' '-(5-amino salicylic acid) zinc phthalocyanine (I), tetra-(5-amino salicylic acid) zinc phthalocyanine(E) and 4,4',4' '- triamino-4' ' '-nitro zinc phthalocyanine (S). The reaction of 4- nitro Phthalonitrile and 4- amino and the structure of compound I is confirmed and its formation was proven.

pH-sensitive release of fungal metabolites from chitosan nanoparticles for effective cytotoxicity in prostate cancer (PC3) cells

2021 ◽  
Vol 102 ◽  
pp. 165-172
Author(s):  
Kandasamy Saravanakumar ◽  
Arokia Vijaya Anand Mariadoss ◽  
Anbazhagan Sathiyaseelan ◽  
Karthikkumar Venkatachalam ◽  
Xiaowen Hu ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Chitosan Nanoparticles ◽  
Ph Sensitive ◽  
Fungal Metabolites ◽  
Pc3 Cells
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