SYNTHESIS OF MUTUAL PRODRUG OF P-AMINO SALICYLIC ACID (PAS) AND ISONIAZID(INH), WITH POSSIBLE ENHANCEMENT PHYSICOCHEMICAL PROPERTIES

2010 ◽  
Vol 13 (3) ◽  
pp. 7-13
Author(s):  
Ahlam J. Qasir ◽  
◽  
Ahmed D. Jassim ◽  
Keyword(s):  
Salicylic Acid ◽  
Physicochemical Properties ◽  
Amino Salicylic Acid ◽  
Mutual Prodrug

Synthesis and Characterization of New Zinc Phthalocyanine - Dodecenyl Succinic Anhydride Benzoic Groups

2020 ◽  
Vol 17 (6) ◽  
pp. 488-495
Author(s):  
Hussein Ali Al-Bahrani ◽  
Mohanad Mousa Kareem ◽  
Abdul Amir Kadhum ◽  
Nour A. Alrazzak
Keyword(s):  
Salicylic Acid ◽  
Succinic Anhydride ◽  
Zinc Phthalocyanine ◽  
Central Metal ◽  
Target Compound ◽  
Compound I ◽  
Metal Phthalocyanines ◽  
Metal Atoms ◽  
Amino Salicylic Acid

Background: The phthalocyanines a series of compounds involves four iso-indole units linked by aza nitrogen atoms bonded with metal atoms that are normally located in the center a phthalocyanines ring. Some of the central metal-phthalocyanines can be excited by ultraviolet light and emit a fluorescence in far-red region. Objective: To synthesize a derivative of phthalocyanines namely 4,4',4' '-tri-(dodecenyl succinic anhydride)- 4' ' '-(5-amino salicylic acid) zinc phthalocyanine with a zinc central metal. Materials and Methods: The reaction of 4- nitro Phthalonitrile and 4- amino Phthalonitrile with ZnCl2 in the presence of dimethyl amino ethanol afforded 4,4',4' '-triamino-4' ' '-nitro zinc phthalocyanine. This product reacted with 5-amino salicylic acid to yield tetra-(5-amino salicylic acid) zinc phthalocyanine. A dodecenyl succinic anhydride was added on the amine group of benzoic rings to afford 4,4',4' '-tri-(dodecenyl succinic anhydride)-4' ' '-(5-amino salicylic acid) zinc phthalocyanine(I), the target compound. Results and Discussion: Compound I is successfully synthesized with a yield of 72% from tetra-(5-amino salicylic acid) zinc phthalocyanine with dodecenyl succinic anhydride. Conclusion: The newly synthesized molecule of 4,4',4' '-tri-(dodecenyl succinic anhydride)-4' ' '-(5-amino salicylic acid) zinc phthalocyanine (I), tetra-(5-amino salicylic acid) zinc phthalocyanine(E) and 4,4',4' '- triamino-4' ' '-nitro zinc phthalocyanine (S). The reaction of 4- nitro Phthalonitrile and 4- amino and the structure of compound I is confirmed and its formation was proven.

Crystals and molecular structure ofp-amino-salicylic acid

1954 ◽  
Vol 7 (12) ◽  
pp. 808-812 ◽  
Author(s):  
F. Bertinotti ◽  
C. Giacomello ◽  
A. M. Liquori
Keyword(s):  
Molecular Structure ◽  
Salicylic Acid ◽  
Amino Salicylic Acid

Fluorescence properties of 4-amino salicylic acid in polymers

2010 ◽  
Vol 216 (1) ◽  
pp. 51-58 ◽  
Author(s):  
Kanchan Suyal ◽  
Neeraj Kumar Joshi ◽  
Ranjana Rautela ◽  
Hem Chandra Joshi ◽  
Sanjay Pant
Keyword(s):  
Salicylic Acid ◽  
Fluorescence Properties ◽  
Amino Salicylic Acid
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