scholarly journals Chronic Kidney Disease and Cerebrovascular Disease: Consensus and Guidance From a KDIGO Controversies Conference

Stroke ◽  
2021 ◽  
Author(s):  
Dearbhla M. Kelly ◽  
Zanfina Ademi ◽  
Wolfram Doehner ◽  
Gregory Y.H. Lip ◽  
Patrick Mark ◽  
...  
Keyword(s):  
Risk Factors ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Cerebrovascular Disease ◽  
Vascular Cognitive Impairment ◽  
Arterial Disease ◽  
Cerebral Hypoperfusion ◽  
Stroke Severity ◽  
Underlying Mechanisms ◽  
Peripheral Arterial

The global health burden of chronic kidney disease is rapidly rising, and chronic kidney disease is an important risk factor for cerebrovascular disease. Proposed underlying mechanisms for this relationship include shared traditional risk factors such as hypertension and diabetes, uremia-related nontraditional risk factors, such as oxidative stress and abnormal calcium-phosphorus metabolism, and dialysis-specific factors such as cerebral hypoperfusion and changes in cardiac structure. Chronic kidney disease frequently complicates routine stroke risk prediction, diagnosis, management, and prevention. It is also associated with worse stroke severity, outcomes and a high burden of silent cerebrovascular disease, and vascular cognitive impairment. Here, we present a summary of the epidemiology, pathophysiology, diagnosis, and treatment of cerebrovascular disease in chronic kidney disease from the Kidney Disease: Improving Global Outcomes Controversies Conference on central and peripheral arterial disease with a focus on knowledge gaps, areas of controversy, and priorities for research.

scholarly journals Subclinical peripheral arterial disease in patients with chronic kidney disease: Prevalence and related risk factors

2005 ◽  
Vol 67 ◽  
pp. S44-S47 ◽  
Author(s):  
Soledad Garcia de Vinuesa ◽  
Mayra Ortega ◽  
Patricia Martinez ◽  
Marian Goicoechea ◽  
Francisco Gomez Campdera ◽  
...  
Keyword(s):  
Risk Factors ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Peripheral Arterial Disease ◽  
Arterial Disease ◽  
Disease Prevalence ◽  
Chronic Kidney Disease Prevalence ◽  
Related Risk ◽  
Peripheral Arterial

scholarly journals Risk Factors for Peripheral Arterial Disease Among Patients With Chronic Kidney Disease

2012 ◽  
Vol 110 (1) ◽  
pp. 136-141 ◽  
Author(s):  
Jing Chen ◽  
Emile R. Mohler ◽  
Dawei Xie ◽  
Michael G. Shlipak ◽  
Raymond R. Townsend ◽  
...  
Keyword(s):  
Risk Factors ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Peripheral Arterial Disease ◽  
Arterial Disease ◽  
Peripheral Arterial

scholarly journals Contrast-induced nephropathy in patients with chronic kidney disease and peripheral arterial disease

2015 ◽  
Vol 4 (6) ◽  
pp. 205846011558303 ◽  
Author(s):  
Christian Kroneberger ◽  
Christian N Enzweiler ◽  
Andre Schmidt-Lucke ◽  
Ralph-Ingo Rückert ◽  
Ulf Teichgräber ◽  
...  
Keyword(s):  
Risk Factors ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Peripheral Arterial Disease ◽  
Serum Creatinine ◽  
Contrast Material ◽  
Arterial Disease ◽  
Contrast Induced Nephropathy ◽  
Related Risk ◽  
Peripheral Arterial

Background The risk for contrast-induced nephropathy (CIN) after intra-arterial application of an iodine-based contrast material is unknown for patients with chronic kidney disease (CKD) and peripheral arterial disease (PAD). Purpose To investigate the incidence of CIN in patients with CKD and PAD. Material and Methods This retrospective study was approved by the local ethics committee. One hundred and twenty patients with 128 procedures (73 with baseline eGFR in the range of 45–60 mL/min/1.73m2, 55 with eGFR < 45 mL/min/1.73m2) were evaluated. All patients received intra-arterially an iodine-based low-osmolar contrast material (CM) after adequate intravenous hydration with isotonic NaCl 0.9% solution. CIN was defined as an increase in serum creatinine of more than 44 μmol/L within 4 days. The influence of patient-related risk factors (age, weight, body mass index, eGFR, serum creatinine, hypertension, diabetes mellitus, coronary heart disease, heart failure) and therapy-related risk factors (amount of CM, nephrotoxic drugs, number of CM applications) on CIN were examined. Results CIN developed in 0% (0/73) of procedures in patients with PAD and an eGFR in the range of 45–60 mL/min/1.73m2 and in 10.9% (6/55) of procedures in patients with an eGFR <45 mL/min/1.73m2. No risk factor significantly influenced the development of CIN, although baseline serum creatinine ( P = 0.06) and baseline eGFR ( P = 0.10) showed a considerable dependency. Conclusion Patients with an eGFR in the range of 45–60 mL/min/1.73m2 and PAD seem not at risk for CIN after intra-arterial CM application and adequate hydration. Whereas, an eGFR < 45 mL/min/1.73m2 correlated with a risk of 10.9% for a CIN.

Assessment of Renal Function and Risk Factors for Chronic Kidney Disease in Patients With Peripheral Arterial Disease

Angiology ◽  
2017 ◽  
Vol 68 (9) ◽  
pp. 776-781 ◽  
Author(s):  
Xi-Bei Jia ◽  
Xi-Hua Hou ◽  
Qiu-Bo Ma ◽  
Xiao-Wen Cai ◽  
Yi-Ran Li ◽  
...  
Keyword(s):  
Risk Factors ◽  
Chronic Kidney Disease ◽  
Renal Function ◽  
Kidney Disease ◽  
Peripheral Arterial Disease ◽  
Arterial Disease ◽  
High Risk Population ◽  
High Prevalence ◽  
Independent Risk Factors ◽  
Peripheral Arterial

Chronic kidney disease (CKD) and peripheral arterial disease (PAD) share common risk factors. We assessed renal function and the prevalence of CKD in patients with PAD and investigated the characteristics of the risk factors for CKD in this population. Renal function of 421 patients with PAD was evaluated. Among the participants, 194 (46.1%) patients had decreased estimated glomerular filtration rate (eGFR). The prevalence of CKD was much higher among patients with PAD. Hypertension (odds ratios [ORs] 2.156, 95% confidence interval [CI] 1.413-3.289, P < .001), serum uric acid (OR 3.794, 95% CI 2.220-6.450, P < .001), and dyslipidemia (OR 1.755, 95% CI 1.123-2.745, P = .014) were significantly associated with CKD and the independent risk factors for CKD in patients with PAD. CKD is common and has a high prevalence in a population with PAD. Patients with PAD may be considered as a high-risk population for CKD. Recognition and modification of risk factors for CKD might beneficially decrease CKD incidence and improve prognosis in patients with PAD.

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