scholarly journals Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Risk Score in Young Adults Predicts Coronary Artery and Abdominal Aorta Calcium in Middle Age

Circulation ◽  
2016 ◽  
Vol 133 (2) ◽  
pp. 139-146 ◽  
Author(s):  
Samuel S. Gidding ◽  
Jamal S. Rana ◽  
Christopher Prendergast ◽  
Henry McGill ◽  
J. Jeffery Carr ◽  
...  
Keyword(s):  
Young Adults ◽  
Coronary Artery ◽  
Risk Score ◽  
Abdominal Aorta ◽  
Middle Age

Abstract 31: Prediction of coronary artery and abdominal aortic calcium in middle-aged adults using the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) risk score: the CARDIA study

Circulation ◽  
2014 ◽  
Vol 129 (suppl_1) ◽  
Author(s):  
Christopher Prendergast ◽  
Jamal S Rana ◽  
Alex McMahan ◽  
Henry McGill ◽  
Jeff Carr ◽  
...  
Keyword(s):  
Risk Factors ◽  
Young Adults ◽  
Coronary Artery ◽  
Risk Score ◽  
Model Performance ◽  
Baseline Risk ◽  
Risk Scores ◽  
Abdominal Aortic ◽  
Point Increase ◽  
Better Than

Background: Risk scores to predict coronary and abdominal atherosclerosis have been developed from autopsy specimens from the right coronary artery and descending aorta and risk factors measured post-mortem in the Pathobiological Determinants of Atherosclerosis in Youth Study (PDAY), cohort aged 15-34 years. While the PDAY risk score predicts coronary artery calcium (CAC) up to 15 years before its assessment in Coronary Artery Risk Development in Young Adults (CARDIA), the clinical validity at 25 years follow up and of the abdominal score to predict abdominal aortic calcium (AAC) has not been tested. Objectives: To test the hypotheses: 1) PDAY risk scores at CARDIA baseline (cohort aged 18-30 years) predict CAC and abdominal aortic calcium (AAC) at year 25 better than PDAY risk scores measured at subsequent time points. 2) Change in risk over time will improve associations in Aim 1. Methods: The CARDIA study assessed CAC and AAC by computed tomography in young adults participating at year 25. The PDAY risk score was calculated from risk factors measured at the CARDIA examinations at years 0 (cohort aged 18-30 years), 5, 10, 15 and 25 (age 43-55 years). Results: Age and gender independent PDAY risk scores increased from CARDIA year 0 to year 25 (coronary from 1.80 to 4.95, abdomen from 1.88 to 3.18). Prevalence of any CAC was 28% and AAC was 53%. For a one point increase in risk score, baseline risk predicted CAC and AAC better than year 25 risk; change in risk improved the prediction further (Table). C-statistics for CAC prediction were higher at year 0 but similar at years 0 and 25 for AAC. Further analyses using PDAY scores calculated at 5 year intervals prior to the CT scan confirmed that CAC at baseline and AAC at year 5 had the highest Odds Ratios for a one point increase in score (AAC year 5 Odds Ratio 1.35 (1.30-1.41)). Conclusions: PDAY risk scores, applied to living adults in the CARDIA study, predicted CAC and AAC in 43-55 year old adults; including change in risk slightly improves model performance.

Abstract P181: Young Adult Risk Factor Burden and Sleep Hypertension in Middle-Age: the Coronary Artery Risk Development in Young Adults Study

Circulation ◽  
2019 ◽  
Vol 139 (Suppl_1) ◽  
Author(s):  
John N Booth ◽  
Joseph Schwartz ◽  
Norrina Allen ◽  
Bryron Jaeger ◽  
Cora Lewis ◽  
...  
Keyword(s):  
Young Adults ◽  
Risk Factor ◽  
Coronary Artery ◽  
Young Adult ◽  
Middle Age ◽  
Risk Factor Burden

scholarly journals Fasting Glucose Variability in Young Adulthood and Cognitive Function in Middle Age: The Coronary Artery Risk Development in Young Adults (CARDIA) Study

Diabetes Care ◽  
2018 ◽  
Vol 41 (12) ◽  
pp. 2579-2585 ◽  
Author(s):  
Michael P. Bancks ◽  
Mercedes R. Carnethon ◽  
David R. Jacobs ◽  
Lenore J. Launer ◽  
Jared P. Reis ◽  
...  
Keyword(s):  
Young Adults ◽  
Coronary Artery ◽  
Cognitive Function ◽  
Young Adulthood ◽  
Middle Age ◽  
Fasting Glucose ◽  
Glucose Variability

Usefulness of the Framingham risk score and body mass index to predict early coronary artery calcium in young adults (Muscatine Study)

2001 ◽  
Vol 88 (5) ◽  
pp. 509-515 ◽  
Author(s):  
Larry T Mahoney ◽  
Trudy L Burns ◽  
William Stanford ◽  
Brad H Thompson ◽  
John D Witt ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Young Adults ◽  
Coronary Artery ◽  
Body Mass ◽  
Risk Score ◽  
Coronary Artery Calcium ◽  
Framingham Risk Score ◽  
Framingham Risk
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