scholarly journals Fasting Glucose Variability in Young Adulthood and Cognitive Function in Middle Age: The Coronary Artery Risk Development in Young Adults (CARDIA) Study

Diabetes Care ◽  
2018 ◽  
Vol 41 (12) ◽  
pp. 2579-2585 ◽  
Author(s):  
Michael P. Bancks ◽  
Mercedes R. Carnethon ◽  
David R. Jacobs ◽  
Lenore J. Launer ◽  
Jared P. Reis ◽  
...  
Keyword(s):  
Young Adults ◽  
Coronary Artery ◽  
Cognitive Function ◽  
Young Adulthood ◽  
Middle Age ◽  
Fasting Glucose ◽  
Glucose Variability

scholarly journals Association Between Fasting Glucose Variability in Young Adulthood and the Progression of Coronary Artery Calcification in Middle Age

Diabetes Care ◽  
2020 ◽  
Vol 43 (10) ◽  
pp. 2574-2580
Author(s):  
Weijing Feng ◽  
Zhibin Li ◽  
Wenjie Guo ◽  
Xianglin Fan ◽  
Feiran Zhou ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Young Adulthood ◽  
Coronary Artery Calcification ◽  
Middle Age ◽  
Fasting Glucose ◽  
Glucose Variability

scholarly journals Association Between Fasting Glucose Variability in Young Adulthood and the Progression of Coronary Artery Calcification in Middle Age

2020 ◽  
Author(s):  
Weijing Feng ◽  
Zhibin Li ◽  
Wenjie Guo ◽  
Xianglin Fan ◽  
Feiran Zhou ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Young Adulthood ◽  
Coronary Artery Calcification ◽  
Middle Age ◽  
Fasting Glucose ◽  
Glucose Variability ◽  
Diabetes Incidence ◽  
The Difference ◽  
Average Real Variability

<b>OBJECTIVE</b> <p><a>To investigate whether intraindividual variability of fasting glucose (FG) in young adulthood is associated with coronary artery calcification (CAC) progression in middle age.</a></p> <p><b>RESEARCH DESIGN AND METHODS</b></p> <p>We included 2,256 CARDIA (<a></a><a>Coronary Artery Risk Development Study in Young Adults</a>) participants with CAC assessment by computed tomography scanner at baseline (2000–2001) and 10 years later (2010-2011). CAC progression was assessed for each individual as the difference of logarithmic CAC scores at follow-up and baseline (log [CAC (follow-up) + 1] - log [CAC (baseline) + 1]). FG variability was defined by the coefficient of variation about the mean FG (FG-CV), the SD of FG (FG-SD), and the average real variability of FG (FG-ARV) during 10-year follow-up. We investigated the association between FG variability and CAC progression with adjustment for demographics, clinical risk factors, mean FG level, change in FG level, diabetes incidence and medication use.</p> <p><b>RESULTS</b></p> <p>After multivariable adjustment, 1-SD increment in FG-CV was associated with worse progression of CAC as demonstrated as percent change in CAC with 5.9% (incident CAC, 95% CI 1.0%, 10.7%) and 6.7% (any CAC progression, 95% CI 2.3%, 11.1%) progression during 10 years. Similar findings were also observed in FG-SD and FG-ARV.</p> <p><b>CONCLUSIONS</b></p> <p>Higher FG variability during young adulthood was associated with greater CAC progression in middle age, suggesting its value in predicting risk for subclinical coronary artery diseases.</p>

scholarly journals Association Between Fasting Glucose Variability in Young Adulthood and the Progression of Coronary Artery Calcification in Middle Age

2020 ◽  
Author(s):  
Weijing Feng ◽  
Zhibin Li ◽  
Wenjie Guo ◽  
Xianglin Fan ◽  
Feiran Zhou ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Young Adulthood ◽  
Coronary Artery Calcification ◽  
Middle Age ◽  
Fasting Glucose ◽  
Glucose Variability ◽  
Diabetes Incidence ◽  
The Difference ◽  
Average Real Variability

<b>OBJECTIVE</b> <p><a>To investigate whether intraindividual variability of fasting glucose (FG) in young adulthood is associated with coronary artery calcification (CAC) progression in middle age.</a></p> <p><b>RESEARCH DESIGN AND METHODS</b></p> <p>We included 2,256 CARDIA (<a></a><a>Coronary Artery Risk Development Study in Young Adults</a>) participants with CAC assessment by computed tomography scanner at baseline (2000–2001) and 10 years later (2010-2011). CAC progression was assessed for each individual as the difference of logarithmic CAC scores at follow-up and baseline (log [CAC (follow-up) + 1] - log [CAC (baseline) + 1]). FG variability was defined by the coefficient of variation about the mean FG (FG-CV), the SD of FG (FG-SD), and the average real variability of FG (FG-ARV) during 10-year follow-up. We investigated the association between FG variability and CAC progression with adjustment for demographics, clinical risk factors, mean FG level, change in FG level, diabetes incidence and medication use.</p> <p><b>RESULTS</b></p> <p>After multivariable adjustment, 1-SD increment in FG-CV was associated with worse progression of CAC as demonstrated as percent change in CAC with 5.9% (incident CAC, 95% CI 1.0%, 10.7%) and 6.7% (any CAC progression, 95% CI 2.3%, 11.1%) progression during 10 years. Similar findings were also observed in FG-SD and FG-ARV.</p> <p><b>CONCLUSIONS</b></p> <p>Higher FG variability during young adulthood was associated with greater CAC progression in middle age, suggesting its value in predicting risk for subclinical coronary artery diseases.</p>

scholarly journals Association Between Fasting Glucose Variability in Young Adulthood and the Progression of Coronary Artery Calcification in Middle Age: The CARDIA Study

2020 ◽  
Author(s):  
Weijing Feng ◽  
Zhibin Li ◽  
Wenjie Guo ◽  
Xianglin Fan ◽  
Feiran Zhou ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Young Adulthood ◽  
Coronary Artery Calcification ◽  
Middle Age ◽  
Fasting Glucose ◽  
Glucose Variability ◽  
Diabetes Incidence ◽  
The Difference ◽  
Average Real Variability

<b>OBJECTIVE</b> <p><a>To investigate whether intraindividual variability of fasting glucose (FG) in young adulthood is associated with coronary artery calcification (CAC) progression in middle age.</a></p> <p><b>RESEARCH DESIGN AND METHODS</b></p> <p>We included 2,256 CARDIA (<a></a><a>Coronary Artery Risk Development Study in Young Adults</a>) participants with CAC assessment by computed tomography scanner at baseline (2000–2001) and 10 years later (2010-2011). CAC progression was assessed for each individual as the difference of logarithmic CAC scores at follow-up and baseline (log [CAC (follow-up) + 1] - log [CAC (baseline) + 1]). FG variability was defined by the coefficient of variation about the mean FG (FG-CV), the SD of FG (FG-SD), and the average real variability of FG (FG-ARV) during 10-year follow-up. We investigated the association between FG variability and CAC progression with adjustment for demographics, clinical risk factors, mean FG level, change in FG level, diabetes incidence and medication use.</p> <p><b>RESULTS</b></p> <p>After multivariable adjustment, 1-SD increment in FG-CV was associated with worse progression of CAC as demonstrated as percent change in CAC with 5.9% (incident CAC, 95% CI 1.0%, 10.7%) and 6.7% (any CAC progression, 95% CI 2.3%, 11.1%) progression during 10 years. Similar findings were also observed in FG-SD and FG-ARV.</p> <p><b>CONCLUSIONS</b></p> <p>Higher FG variability during young adulthood was associated with greater CAC progression in middle age, suggesting its value in predicting risk for subclinical coronary artery diseases.</p>

scholarly journals Heart Rate Variability and Cognitive Function In Middle-Age Adults: The Coronary Artery Risk Development in Young Adults

2017 ◽  
Vol 31 (1) ◽  
pp. 27-34 ◽  
Author(s):  
Adina Zeki Al Hazzouri ◽  
Tali Elfassy ◽  
Mercedes R Carnethon ◽  
Donald M Lloyd-Jones ◽  
Kristine Yaffe
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Young Adults ◽  
Coronary Artery ◽  
Cognitive Function ◽  
Middle Age
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