Pressure Natriuresis After Adrenomedullin in Anesthetized Spontaneously Hypertensive Rats

Hypertension ◽  
1997 ◽  
Vol 30 (3) ◽  
pp. 660-663 ◽  
Author(s):  
Toshiaki Kurashina ◽  
Ami R. Patel ◽  
Joey P. Granger ◽  
Kent A. Kirchner
Keyword(s):  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Pressure Natriuresis

scholarly journals Role of NO on pressure-natriuresis in Wistar-Kyoto and spontaneously hypertensive rats

1993 ◽  
Vol 43 (1) ◽  
pp. 205-211 ◽  
Author(s):  
Hideki Ikenaga ◽  
Hiromichi Suzuki ◽  
Naohito Ishii ◽  
Hajime Itoh ◽  
Takao Saruta
Keyword(s):  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Wistar Kyoto ◽  
Pressure Natriuresis

Renal interstitial hydrostatic pressure during pressure natriuresis in hypertension

1988 ◽  
Vol 255 (5) ◽  
pp. R756-R759 ◽  
Author(s):  
A. A. Khraibi ◽  
F. G. Knox
Keyword(s):  
Hydrostatic Pressure ◽  
Spontaneously Hypertensive Rats ◽  
Left Kidney ◽  
Hypertensive Rats ◽  
Polyethylene Matrix ◽  
Spontaneously Hypertensive ◽  
Wistar Kyoto Rats ◽  
Fractional Excretion Of Sodium ◽  
Wistar Kyoto ◽  
Pressure Natriuresis

The objective of this study was to test the hypothesis that changes in renal perfusion pressure (RPP) are not fully transmitted to the renal interstitium in spontaneous hypertension in comparison with normotensive states. Okamoto spontaneously hypertensive and normotensive Wistar-Kyoto rats were used in this study. Renal interstitial hydrostatic pressure (RIHP) was measured directly and continuously via a polyethylene matrix that was implanted chronically in the left kidney 3 wk before RIHP measurement. When RPP was allowed to increase from 136 +/- 0.5 to 162 +/- 1.3 mmHg in male spontaneously hypertensive rats, RIHP was not significantly changed from 3.7 +/- 0.9 to 4.6 +/- 1.1 mmHg, and fractional excretion of sodium (FENa) increased significantly from 0.26 +/- 0.12 to 0.65 +/- 0.15% (P less than 0.05). When RPP was allowed to change from 104 +/- 0.9 to 127 +/- 1.3 mmHg in male Wistar-Kyoto rats, RIHP increased markedly from 4.0 +/- 0.3 to 7.2 +/- 0.4 mmHg (P less than 0.05), and FENa was significantly elevated from 0.27 +/- 0.08 to 2.02 +/- 0.55% (P less than 0.05). In conclusion, spontaneously hypertensive rats have a blunted increase in RIHP and pressure natriuresis response in comparison with Wistar-Kyoto rats. Thus, in Okamoto spontaneously hypertensive rats, the effect of RPP on RIHP is attenuated, leading to a blunted pressure natriuresis response.

scholarly journals Effects of renal denervation on pressure-natriuresis in spontaneously hypertensive rats.

1993 ◽  
Vol 57 (11) ◽  
pp. 1097-1105 ◽  
Author(s):  
JIRO KUBOTA ◽  
HIKARU NISHIMURA ◽  
MASAKUNI UEYAMA ◽  
KEISHIRO KAWAMURA
Keyword(s):  
Spontaneously Hypertensive Rats ◽  
Renal Denervation ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Pressure Natriuresis
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