scholarly journals Modification of pressure natriuresis by long-term losartan in spontaneously hypertensive rats.

Hypertension ◽  
1994 ◽  
Vol 24 (4) ◽  
pp. 467-473 ◽  
Author(s):  
R L Kline ◽  
F Liu
Keyword(s):  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Pressure Natriuresis

The persistent effect of long-term enalapril on pressure natriuresis in spontaneously hypertensive rats

1997 ◽  
Vol 273 (1) ◽  
pp. F104-F112 ◽  
Author(s):  
S. A. Dukacz ◽  
M. A. Adams ◽  
R. L. Kline
Keyword(s):  
Arterial Pressure ◽  
Spontaneously Hypertensive Rats ◽  
Day Treatment ◽  
Renin Angiotensin System ◽  
Hypertensive Rats ◽  
Angiotensin System ◽  
Spontaneously Hypertensive ◽  
Persistent Effect ◽  
Pressure Natriuresis

Long-term angiotensin-converting enzyme inhibitor treatment has been shown to have a persistent antihypertensive effect in spontaneously hypertensive rats (SHR) long after discontinuation of treatment. To test the hypothesis that this persistent effect involves a shift in the pressure-natriuresis relation, we performed experiments in male, anesthetized SHR at 18 wk of age with fixed neural and hormonal influences on the kidney. Renal function was assessed at various levels of arterial pressure using standard clearance techniques. Enalapril (25 mg.kg-1.day-1 in drinking water) was administered from 4 to 14 wk of age and again 3 days before renal function studies. The following four groups of SHR were studied: 1) 10-wk treatment, 2) 10-wk + 3-day treatment, 3) 3-day treatment, and 4) untreated. Groups 1 and 4 had an intact renin-angiotensin system; groups 2 and 3 had the renin-angiotensin system blocked. Mean arterial pressure (MAP, mmHg; means +/- SE) under Inactin anesthesia was 139 +/- 4 (n = 9), 109 +/- 3 (n = 8), 149 +/- 1 (n = 9), and 181 +/- 7 mmHg (n = 9) for each of the four groups, respectively. Glomerular filtration rate was similar in all groups at resting levels of MAP, whereas renal blood flow was elevated in all treatment groups when compared with that in untreated SHR. Pressure-natriuresis, pressure-diuresis, and pressure-fractional sodium excretion curves for the 10-wk treatment group and 3-day only treatment group were shifted leftward to significantly lower pressures by approximately 25 mmHg, compared with the untreated group. The curves for the treated +3-day group were shifted an additional 30 mmHg to the left. The relationship between renal artery pressure (RAP) and renal interstitial hydrostatic pressure was also shifted 25-30 mmHg but only in rats that received the long-term treatment with enalapril. Three-day enalapril had no significant effect on this relationship. These data indicate that the persistent effect of long-term enalapril treatment on arterial pressure in SHR is the result of a shift in the pressure-natriuresis relationship. The mechanism for this effect involves hemodynamic changes that act to improve transmission of RAP to the interstitium, resulting in enhanced sodium excretion for a given level of RAP.

Pressure Natriuresis After Adrenomedullin in Anesthetized Spontaneously Hypertensive Rats

Hypertension ◽  
1997 ◽  
Vol 30 (3) ◽  
pp. 660-663 ◽  
Author(s):  
Toshiaki Kurashina ◽  
Ami R. Patel ◽  
Joey P. Granger ◽  
Kent A. Kirchner
Keyword(s):  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Pressure Natriuresis

Long-term administration of prazosin improves bladder storage function: Results from a study in spontaneously hypertensive rats

2011 ◽  
Vol 18 (11) ◽  
pp. 785-791 ◽  
Author(s):  
Nobuhiro Haga ◽  
Ken Aikawa ◽  
Kei Ishibashi ◽  
Tomohiko Yanagida ◽  
Masanori Nomiya ◽  
...  
Keyword(s):  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Storage Function ◽  
Term Administration

scholarly journals Long‐term Treatment with Kefir Probiotics Ameliorates Cardiac Function in Spontaneously Hypertensive Rats

2019 ◽  
Vol 33 (S1) ◽  
Author(s):  
Mirian Almeida Silva‐Cutini ◽  
Simone Alves Almeida ◽  
Andrews Marques Nascimento ◽  
Glaucia Rodrigues Abreu ◽  
Nazaré Souza Bissoli ◽  
...  
Keyword(s):  
Cardiac Function ◽  
Spontaneously Hypertensive Rats ◽  
Term Treatment ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Long Term Treatment
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