scholarly journals Blood concentration and urinary excretion of captopril (SQ 14,225) in patients with chronic renal failure.

Hypertension ◽  
1981 ◽  
Vol 3 (4) ◽  
pp. 456-459 ◽  
Author(s):  
K Onoyama ◽  
H Hirakata ◽  
K Iseki ◽  
S Fujimi ◽  
T Omae ◽  
...  
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Urinary Excretion ◽  
Blood Concentration

Effects of age and chronic renal failure on the urinary excretion kinetics of famotidine in man

1988 ◽  
Vol 34 (1) ◽  
pp. 41-46 ◽  
Author(s):  
J. H. Lin ◽  
A. N. Chremos ◽  
K. C. Yeh ◽  
J. Antonello ◽  
G. A. Hessey
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Urinary Excretion ◽  
Excretion Kinetics ◽  
Kinetics Of

Effect of Omeprazole on the Urinary Excretion of Aluminum and Phosphorus in Chronic Renal Failure

Nephron ◽  
1998 ◽  
Vol 78 (3) ◽  
pp. 352-353 ◽  
Author(s):  
B. Di Iorio ◽  
A. Bruno ◽  
V. Terracciano ◽  
C. Altieri ◽  
D. Papaleo ◽  
...  
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Urinary Excretion

Concentrations in Serum and Urinary Excretion of Guanidine, 1-Methylguanidine, and 1,1-Dimethylguanidine in Chronic Renal Failure

1973 ◽  
Vol 19 (6) ◽  
pp. 583-585 ◽  
Author(s):  
Israel M Stein ◽  
Michael J Micklus
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Urinary Excretion ◽  
Uremic Toxins ◽  
Mean Values ◽  
Uremic Syndrome ◽  
The Mean ◽  
Uremic Patients ◽  
Urine Specimens ◽  
Serum And Urine

Abstract Guanidine (G), 1-methylguanidine (MG), and 1,1-dimethylguanidine (DMG) have long been implicated as uremic "toxins." A method has been developed for determining G, MG, and DMG in serum and urine. Specimens were chromatographed on carboxylate resin, with use of 1 molar NaOH, and quantitated colorimetrically with a modification of the Voges— Proskauer reaction. The mean values for G and MG in the serum of uremic patients were 0.3 and 0.4 mg per liter, respectively. DMG was not detected. Although the urinary excretion of MG is significantly increased in renal failure, the concentrations of G, MG, and DMG in serum are not markedly increased, and it is therefore unlikely that G, MG, or DMG contribute to the toxic manifestations of the uremic syndrome.

Gastrointestinal Absorption and Urinary Excretion of Aluminium in Patients with Predialysis Chronic Renal Failure

1988 ◽  
Vol 63 (5) ◽  
pp. 351-354 ◽  
Author(s):  
Knut P. Nordal ◽  
Eilif Dahl ◽  
Kirsten Sørhus ◽  
Knut J. Berg ◽  
Yngvar Thomassen ◽  
...  
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Urinary Excretion ◽  
Gastrointestinal Absorption ◽  
Predialysis Chronic Renal Failure

Renal Excretion of Antidiuretic Hormone in Healthy Subjects and Patients with Renal Failure

1984 ◽  
Vol 67 (3) ◽  
pp. 307-312 ◽  
Author(s):  
Wojciech Pruszczynski ◽  
Henri Caillens ◽  
Luc Drieu ◽  
Luc Moulonguet-Doleris ◽  
Raymond Ardaillou
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Chronic Renal Failure ◽  
Plasma Concentration ◽  
Urinary Excretion ◽  
Antidiuretic Hormone ◽  
Healthy Subjects ◽  
Excretion Rate ◽  
Urinary Excretion Rate ◽  
Fractional Clearance

1. Urinary clearance of antidiuretic hormone (ADH) has been measured under basal conditions and during intravenous administration of arginine vasopressin in ten healthy subjects, and only under basal conditions in 18 patients with chronic renal failure and seven patients with acute renal failure at the polyuric phase of the disease. 2. In healthy subjects studied under conditions of mild water diuresis, plasma concentration, urinary excretion rate, urinary clearance and fractional clearance of ADH were 3.3 ± 0.36 pg/ml, 25.2 ± 5.5 pg/min, 7.5 ± 1.2 ml/min and 6.4 ± 1.0% (means ± sem) respectively. When plasma ADH was raised to levels between 7 and 26 pg/ml during intravenous administration of the hormone, urinary excretion rate and urinary clearance of ADH increased. Tubular reabsorption of ADH did not reach a plateau but progressively increased in the range of plasma ADH studied. 3. In patients with chronic renal failure, plasma concentration, urinary excretion rate, urinary clearance and fractional clearance of ADH were 2.8 ± 0.19 pg/ml, 9.4 ± 2.0 pg/min, 3.4 ± 0.6 ml/min and 10.0 ± 2.9% (means ± sem) respectively. Urinary excretion rate and urinary clearance were significantly lower than in healthy subjects. 4. In patients with acute renal failure, plasma concentration, urinary excretion rate, urinary clearance and fractional clearance of ADH were 4.6 ± 0.47 pg/ml, 52.8 ± 15.8 pg/min, 9.5 ± 2.7 ml/min and 24.9 ± 4.4% (means ± sem) respectively. Urinary excretion rate and fractional clearance were higher than in healthy subjects and patients with chronic renal failure. 5. These results demonstrate that most of the filtered ADH is reabsorbed by the tubules. The reabsorptive capability is markedly diminished in patients with acute renal failure at the polyuric phase of the disease.

Urinary excretion of vitamin C in chronic renal failure and after renal transplantation

1986 ◽  
Vol 18 (4) ◽  
pp. 457-462 ◽  
Author(s):  
M. Mydlík ◽  
K. Derzsiová ◽  
V. Pribylincová ◽  
V. Zvara ◽  
M. Takáč
Keyword(s):  
Renal Failure ◽  
Renal Transplantation ◽  
Chronic Renal Failure ◽  
Vitamin C ◽  
Urinary Excretion

scholarly journals Effect of an acute oral protein load on renal acidification in healthy humans and in patients with chronic renal failure.

1997 ◽  
Vol 8 (5) ◽  
pp. 784-792
Author(s):  
N G de Santo ◽  
G Capasso ◽  
G Malnic ◽  
P Anastasio ◽  
L Spitali ◽  
...  
Keyword(s):  
Renal Failure ◽  
Metabolic Acidosis ◽  
Chronic Renal Failure ◽  
Urinary Excretion ◽  
Healthy Subjects ◽  
Tubular Reabsorption ◽  
Renal Tubules ◽  
Acid Base Balance ◽  
Acid Base ◽  
Base Balance

The effect of a meat load on the renal handling of acid-base balance was studied in ten healthy subjects (GFR by inulin clearance = 98.5 +/- 8.14 ml.min-1.1.73 m-2) and in ten patients affected by chronic renal failure (CRF) (GFR = 39.9 +/- 5.3 ml.min-1.1.73 m-2). After the meat load (2 g.kg-1 body weight of cooked unsalted red meat), GFR increased by 26.9% (peak value) over baseline in healthy subjects and by 32% in CRF patients. The acid-base status of the healthy subjects was in the normal range, whereas the CRF patients disclosed a slight metabolic acidosis. After a meat load, there was, in the healthy subjects, an increase in the filtered load of bicarbonate coupled to an enhanced tubular reabsorption and urinary excretion. The time course between bicarbonate load and urinary excretion was coincident. In CRF patients, the increase of bicarbonate tubular load after the meal was associated with an increase in tubular reabsorption but not in urinary excretion of this anion. The relationship between bicarbonate load and reabsorption was linear in both groups up to the highest filtered loads. Baseline titratable acidity (TA) and ammonium (NH4+) excretion (expressed per ml GFR) were increased in CRF patients as compared with control subjects, but no changes were found after the meat load in both groups in these experimental conditions. The data indicate that the renal tubules contribute to the maintenance of acid-base balance both in healthy subjects and in CRF patients by reabsorbing most of the additional bicarbonate load. The transient, but significant, increase in bicarbonate excretion observed in healthy subjects could be related to the increased tubular load of bicarbonate. In CRF patients, tubular bicarbonate reabsorption was more complete, possibly because of the stimulation of H+ secretion by the mild metabolic acidosis. TA and NH4+ did not participate in tubular compensation of the increased buffer load.

Influence of a meat-free diet on the urinary excretion of 3-methylhistidine and creatinine in chronic renal failure

1992 ◽  
Vol 232 (2) ◽  
pp. 129-132 ◽  
Author(s):  
A. GUTIERREZ ◽  
A. ALVESTRAND ◽  
G. A. QURESHI ◽  
J. BERGSTRÖM
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Urinary Excretion
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