Blood Pressure and Its Regulation in Spontaneously Hypertensive Rats Bred on the Lowest Sodium Diet for Normal Growth

Hypertension ◽  
1996 ◽  
Vol 27 (1) ◽  
pp. 90-95 ◽  
Author(s):  
Shuichi Takishita ◽  
Koshiro Fukiyama ◽  
Tanenao Eto ◽  
Nobuyuki Kawazoe ◽  
Yorio Kimura ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Spontaneously Hypertensive Rats ◽  
Normal Growth ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Sodium Diet

scholarly journals Testosterone Increases: Sodium Reabsorption, Blood Pressure, and Renal Pathology in Female Spontaneously Hypertensive Rats on a High Sodium Diet

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Bei Liu ◽  
Daniel Ely
Keyword(s):  
Blood Pressure ◽  
Spontaneously Hypertensive Rats ◽  
Sodium Reabsorption ◽  
Plasma Norepinephrine ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
High Sodium ◽  
Sodium Diet ◽  
Hypertension Development ◽  
High Sodium Diet

Estrogen (E) and testosterone (T) are important in the sexually dimorphic pattern of blood pressure (BP) development. The goal was to examine the effects of endogenous E and exogenous T in the development of hypertension in female spontaneously hypertensive rats (SHR) on a high sodium diet. Female SHR (, 5-week) were divided into four groups: (1) control (), (2) ovariectomized (OVX, ), (3) testosterone implants with intact ovaries (T, ), and (4) ovariectomized + testosterone implants (OVX+T, ). T was given immediately after OVX and replaced every two weeks and they were fed a 3% NaCl diet. BP was measured weekly and plasma norepinephrine (NE) analyzed by HPLC. OVX+T females exhibited the greatest elevation in BP (190 ± 4.0 mmHg) compared to controls at 15 weeks of age (140 ± 3.4 mmHg, ) and a pattern of hypertension development similar to that of male SHR. Females with T treatment showed evidence of glomerulosclerosis. In conclusion, T accelerated the development of hypertension similar to the BP pattern observed in males; the presence of ovaries attenuated the T induced increase in BP; T increased renal sodium reabsorption, and T increased glomerulosclerosis.

scholarly journals Blood pressure and sympathetic nervous function in spontaneously hypertensive rats derived from breeders on low sodium diet.

1986 ◽  
Vol 50 (11) ◽  
pp. 1170-1173 ◽  
Author(s):  
Koshiro FUKIYAMA ◽  
Shuichi TAKISHITA ◽  
Tanenao ETO ◽  
Yorio KIMURA ◽  
Yuji TOMITA ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Sodium Diet ◽  
Low Sodium Diet ◽  
Low Sodium ◽  
Nervous Function ◽  
Sympathetic Nervous
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