Prostacyclin Synthesis Elicited by Endothelin-1 in Rat Aorta Is Mediated by an ET A Receptor via Influx of Calcium and Is Independent of Protein Kinase C

Hypertension ◽  
1995 ◽  
Vol 26 (6) ◽  
pp. 1035-1040 ◽  
Author(s):  
Harold M. Wright ◽  
Kafait U. Malik
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Rat Aorta ◽  
Endothelin 1 ◽  
Kinase C ◽  
Prostacyclin Synthesis

scholarly journals Participation of protein kinase C in endothelin-1-induced contraction in rat aorta: studies with a new tool, calphostin C

1992 ◽  
Vol 107 (2) ◽  
pp. 282-287 ◽  
Author(s):  
Hiroyuki Shimamoto ◽  
Yoriko Shimamoto ◽  
Chiu-Yin Kwan ◽  
Edwin E. Daniel
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Rat Aorta ◽  
Endothelin 1 ◽  
Calphostin C ◽  
Kinase C

scholarly journals Selective Protein Kinase C Isoforms Are Involved in Endothelin-1-Induced Human Uterine Contraction at the End of Pregnancy

2000 ◽  
Vol 63 (5) ◽  
pp. 1567-1573 ◽  
Author(s):  
Isabelle Eude ◽  
Brigitte Paris ◽  
Dominique Cabrol ◽  
Françoise Ferré ◽  
Michelle Breuiller-Fouché
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Uterine Contraction ◽  
Endothelin 1 ◽  
Kinase C ◽  
Protein Kinase C Isoforms

Oleic acid induces endothelin-1 expression through activation of protein kinase C and NF-κB

2003 ◽  
Vol 303 (3) ◽  
pp. 891-895 ◽  
Author(s):  
Joong-Yeol Park ◽  
Yun Mi Kim ◽  
Hai Sun Song ◽  
Ki Young Park ◽  
Young Mi Kim ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Oleic Acid ◽  
Protein Kinase ◽  
Endothelin 1 ◽  
Kinase C

Flow-induced responses in cat isolated pulmonary arteries

1997 ◽  
Vol 83 (5) ◽  
pp. 1617-1622 ◽  
Author(s):  
Larissa A. Shimoda ◽  
Nan A. Norins ◽  
Jane A. Madden
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Pulmonary Arteries ◽  
Transmural Pressure ◽  
Induced Responses ◽  
Synthesis Inhibitor ◽  
Cell Deformability ◽  
Endothelin 1 ◽  
Kinase C ◽  
Intracellular Ca

Shimoda, Larissa A., Nan A. Norins, and Jane A. Madden. Flow-induced responses in cat isolated pulmonary arteries. J. Appl. Physiol.83(5): 1617–1622, 1997.—Isolated, cannulated, endothelium-intact cat pulmonary arteries, averaging 692 ± 104 μm in diameter, were set at a transmural pressure of 10 mmHg and monitored with a video system. Intraluminal flow was increased in steps from 0 to 1.6 ml/min by using a syringe pump. An electronic system held pressure constant by changing outflow resistance. Flow-diameter curves were generated in physiological saline solution. At constant transmural pressure, the arteries constricted in response to increased intraluminal flow. Constriction was not affected by removing extracellular Ca2+ but was abolished after treatment with ryanodine to deplete intracellular Ca2+ stores, with the endothelin-1 synthesis inhibitor phosphoramidon, with the endothelin A-receptor antagonist BQ-123, with the protein kinase C inhibitor staurosporine, or with glutaraldehyde to reduce endothelial cell deformability. The results indicate that isolated pulmonary arteries can constrict in response to intraluminal flow and suggest that constriction is mediated by endothelin-1 and depends on intracellular Ca2+ release and protein kinase C activation.

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