scholarly journals Hypertension in the spontaneously hypertensive rat is linked to the Y chromosome.

Hypertension ◽  
1990 ◽  
Vol 16 (3) ◽  
pp. 277-281 ◽  
Author(s):  
D L Ely ◽  
M E Turner
Keyword(s):  
Y Chromosome ◽  
Spontaneously Hypertensive Rat ◽  
Spontaneously Hypertensive ◽  
Hypertensive Rat

Vascular dysfunction in the stroke-prone spontaneously hypertensive rat is dependent on constrictor prostanoid activity and Y chromosome lineage

2018 ◽  
Vol 132 (1) ◽  
pp. 131-143 ◽  
Author(s):  
Shanzana I. Khan ◽  
Karen L. Andrews ◽  
Ann-Maree Jefferis ◽  
Garry L. Jennings ◽  
Amanda K. Sampson ◽  
...  
Keyword(s):  
Y Chromosome ◽  
Vascular Function ◽  
Disease Risk ◽  
Spontaneously Hypertensive Rat ◽  
Vascular Dysfunction ◽  
Cardiovascular Disease Risk ◽  
Spontaneously Hypertensive ◽  
Downstream Target ◽  
Hypertensive Rat ◽  
Artery Disease

Vascular dysfunction is a hallmark of hypertension and the strongest risk factor to date for coronary artery disease. As Y chromosome lineage has emerged as one of the strongest genetic predictors of cardiovascular disease risk to date, we investigated if Y chromosome lineage modulated this important facet in the stroke-prone spontaneously hypertensive rat (SHRSP) using consomic strains. Here, we show that vascular dysfunction in the SHRSP is attributable to differential cyclooxygenase (COX) activity with nitric oxide (NO) levels playing a less significant role. Measurement of prostacyclin, the most abundant product of COX in the vasculature, confirmed the augmented COX activity in the SHRSP aorta. This was accompanied by functional impairment of the vasodilatory prostacyclin (IP) receptor, while inhibition of the thromboxane (TP) receptor significantly ameliorated vascular dysfunction in the SHRSP, suggesting this is the downstream target responsible for constrictor prostanoid activity. Importantly, Y chromosome lineage was shown to modulate vascular function in the SHRSP through influencing COX activity, prostacyclin levels and IP dysfunction. Vascular dysfunction in the renal and intrarenal arteries was also found to be prostanoid and Y chromosome dependent. Interestingly, despite no apparent differences in agonist-stimulated NO levels, basal NO levels were compromised in the SHRSP aorta, which was also Y chromosome dependent. Thus, in contrast with the widely held view that COX inhibition is deleterious for the vasculature due to inhibition of the vasodilator prostacyclin, we show that COX inhibition abolishes vascular dysfunction in three distinct vascular beds, with IP dysfunction likely being a key mechanism underlying this effect. We also delineate a novel role for Y chromosome lineage in regulating vascular function through modulation of COX and basal NO levels.

The spontaneously hypertensive rat Y chromosome produces an early testosterone rise in normotensive rats

1994 ◽  
Vol 12 (7) ◽  
pp. 769???774 ◽  
Author(s):  
Daniel L. Ely ◽  
Jessica Falvo ◽  
Gail Dunphy ◽  
Ann Caplea ◽  
Ron Salisbury ◽  
...  
Keyword(s):  
Y Chromosome ◽  
Spontaneously Hypertensive Rat ◽  
Spontaneously Hypertensive ◽  
Hypertensive Rat

Y‐chromosome lineage determines cardiovascular organ T‐cell infiltration in the stroke‐prone spontaneously hypertensive rat

2018 ◽  
Vol 32 (5) ◽  
pp. 2747-2756 ◽  
Author(s):  
Shanzana I. Khan ◽  
Karen L. Andrews ◽  
Kristy L. Jackson ◽  
Basimah Memon ◽  
Ann‐Maree Jefferis ◽  
...  
Keyword(s):  
T Cell ◽  
Y Chromosome ◽  
Spontaneously Hypertensive Rat ◽  
Cell Infiltration ◽  
Spontaneously Hypertensive ◽  
T Cell Infiltration ◽  
Hypertensive Rat

Y chromosome locus and hypertension in the stroke prone spontaneously hypertensive rat

1995 ◽  
Vol 13 (12) ◽  
pp. 1501
Author(s):  
Anna E Dominiczak ◽  
A. O. Davidson ◽  
Andrew W. Kelman ◽  
N. Schork ◽  
John L. Reid
Keyword(s):  
Y Chromosome ◽  
Spontaneously Hypertensive Rat ◽  
Spontaneously Hypertensive ◽  
Hypertensive Rat

A Linkage Analysis of the Salt-sensitive Hypertensive Gene in the Stroke-prone Spontaneously Hypertensive Rat (SHRSP)

1996 ◽  
Vol 37 (4) ◽  
pp. 553-553
Author(s):  
Tomoji Mashimo ◽  
Yasuo Nara ◽  
Tomoko Tamada ◽  
Chiho Matsumoto ◽  
Katumi Ikeda ◽  
...  
Keyword(s):  
Linkage Analysis ◽  
Spontaneously Hypertensive Rat ◽  
Spontaneously Hypertensive ◽  
Hypertensive Rat
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