The Biocompatibility of Cyanoacrylate Tissue Adhesive in Conjunction with a Collagen Membrane for Providing Soft and Hard Tissue Regeneration in Extraction Socket Preservation Procedures

2018 ◽  
Vol 38 ◽  
pp. s37-s42 ◽  
Author(s):  
Myron Nevins ◽  
Gerardo Mendoza-Azpur ◽  
Nicola De Angelis ◽  
David Kim
Keyword(s):  
Tissue Regeneration ◽  
Tissue Adhesive ◽  
Collagen Membrane ◽  
Hard Tissue ◽  
Extraction Socket ◽  
Socket Preservation

scholarly journals Cyanoacrylate Tissue Adhesive as a Membrane in Socket Preservation: In Vitro Cytotoxicity and Clinical Evaluation

2020 ◽  
Author(s):  
Gerardo Mendoza Azpur ◽  
Junior ortiz ◽  
Erick Valdivia ◽  
Gabriela de Souza Balbinot ◽  
Fabricio Mezzomo Collares ◽  
...  
Keyword(s):  
Wound Healing ◽  
Clinical Evaluation ◽  
Tissue Adhesive ◽  
Gingival Tissue ◽  
Collagen Membrane ◽  
Socket Preservation ◽  
Post Surgery ◽  
Early Wound

Abstract Background: Cyanoacrylate-based adhesives provide immediate hemostasis when applied; this is attributed to their ability to form a mechanical barrier in the surgical site, favoring the coagulation process and allowing control of bleeding. The purpose of the present study was to demonstrate the in vitro effect of cyanoacrylate-based tissue adhesive and the clinical evaluation of wound healing of freshly extracted sockets with adhesives applied on an exposed collagen membrane, for preservation of the alveolar ridge. Methods: Cytotoxicity was evaluated with sulphoradamine B assay with primary fibroblasts from gingival tissue. The in vivo analysis was carried out in 10 patients needing extraction of single-rooted teeth, who met the inclusion and exclusion criteria and signed the term of free and informed consent. Alveolar preservation was carried out with a mineralized cortical allograft bone substitute and a resorbable collagen membrane that was intentionally left exposed. On the exposed membrane, the Periacryl® 90 HV was applied as a barrier. The biocompatibility of the adhesive was assessed by the Early-Wound Healing Index (EHI) and Early Wound Healing Score (EHS), of perialveolar tissues at time intervals of 12, 30- and 60-days post-surgery. Results: Reduced cell viability was observed for Periacryl® 90 HV when compared with cells without adhesive treatments. No postoperative complications were observed after the application of Periacryl® 90 HV on perialveolar tissues. Conclusion: The use of the Periacryl® 90 HV cyanoacrylate-based tissue adhesive resulted in reduced fibroblast viability in vitro, and adequate results of wound closure in the clinical evaluation of EHI and EHS scores.

scholarly journals 3D-printed gelatin methacrylate (GelMA)/silanated silica scaffold assisted by two-stage cooling system for hard tissue regeneration

2021 ◽  
Vol 8 (2) ◽  
Author(s):  
Eunjeong Choi ◽  
Dongyun Kim ◽  
Donggu Kang ◽  
Gi Hoon Yang ◽  
Bongsu Jung ◽  
...  
Keyword(s):  
Osteogenic Differentiation ◽  
Tissue Regeneration ◽  
Cooling System ◽  
Composite Scaffold ◽  
Human Mesenchymal Stem Cells ◽  
Temperature Control System ◽  
Process Conditions ◽  
Hard Tissue ◽  
Two Stage ◽  
3D Printed

Abstract Among many biomaterials, gelatin methacrylate (GelMA), a photocurable protein, has been widely used in 3D bioprinting process owing to its excellent cellular responses, biocompatibility and biodegradability. However, GelMA still shows a low processability due to the severe temperature dependence of viscosity. To overcome this obstacle, we propose a two-stage temperature control system to effectively control the viscosity of GelMA. To optimize the process conditions, we evaluated the temperature of the cooling system (jacket and stage). Using the established system, three GelMA scaffolds were fabricated in which different concentrations (0, 3 and 10 wt%) of silanated silica particles were embedded. To evaluate the performances of the prepared scaffolds suitable for hard tissue regeneration, we analyzed the physical (viscoelasticity, surface roughness, compressive modulus and wettability) and biological (human mesenchymal stem cells growth, western blotting and osteogenic differentiation) properties. Consequently, the composite scaffold with greater silica contents (10 wt%) showed enhanced physical and biological performances including mechanical strength, cell initial attachment, cell proliferation and osteogenic differentiation compared with those of the controls. Our results indicate that the GelMA/silanated silica composite scaffold can be potentially used for hard tissue regeneration.

Guided Tissue Regeneration in Human Class II Furcation Defects Using a Diphenylphosphorylazide-Cross-Linked Collagen Membrane: A Consecutive Case Series

2003 ◽  
Vol 74 (7) ◽  
pp. 1071-1079 ◽  
Author(s):  
Charles S. Zahedi ◽  
S. Asghar Miremadi ◽  
Gérard Brunel ◽  
Eric Rompen ◽  
Jean-Pierre Bernard ◽  
...  
Keyword(s):  
Tissue Regeneration ◽  
Case Series ◽  
Class Ii ◽  
Guided Tissue Regeneration ◽  
Collagen Membrane ◽  
Consecutive Case ◽  
Human Class ◽  
Furcation Defects

scholarly journals Hard Tissue Preservation in Minimally Invasive Mandibular Third Molar Surgery Using In Situ Hardening TCP Bone Filler

2018 ◽  
Vol 2018 ◽  
pp. 1-9
Author(s):  
Wilfried Engelke ◽  
Marcio Lazzarini ◽  
Víctor Beltrán
Keyword(s):  
Inferior Alveolar Nerve ◽  
Third Molar ◽  
Case Series ◽  
Third Molar Surgery ◽  
Hard Tissue ◽  
Socket Preservation ◽  
Bone Filler ◽  
Close Relationship ◽  
Bone Height

Background. Maintenance of hard tissue in the case of impacted third molars (M3M) with close relationship to the mandibular canal is still a surgical challenge which may be overcome using the inward fragmentation technique. Methods. A consecutive case series of 12 patients required the extraction of 13 impacted M3M with a close relationship to the inferior alveolar nerve (IAN). Via occlusal miniflaps, M3M were exposed occlusal under endoscopic vision and removed by inward fragmentation. All patients received socket preservation with resorbable in situ hardening TCP particles to reduce the risk of pocket formation at the second molar. Results. All 13 sites healed uneventfully. Bone height was assessed using CBCT cross-sectional reformats pre- and 3 months postoperatively. The bone height was reduced by 1.54 mm lingual (SD 0.88), 2.91 mm central (SD 0.93), and 2.08 mm buccal (SD 1.09). Differences were significant at a 0.05% level. No tissue invagination at the extraction sites was observed. Conclusions. Major bone defects can be avoided safely using inward fragmentation surgery. The self-hardening bone filler appears to enhance the mineralization of the intrabony defect.

scholarly journals In Vitro and Ex Vivo Analysis of Collagen Foams for Soft and Hard Tissue Regeneration

In Vivo ◽  
2021 ◽  
Vol 35 (5) ◽  
pp. 2541-2549
Author(s):  
OLE JUNG ◽  
MIKE BARBECK ◽  
LU FAN ◽  
FABIAN KORTE ◽  
CUIFENG ZHAO ◽  
...  
Keyword(s):  
Tissue Regeneration ◽  
Ex Vivo ◽  
Hard Tissue

Three-dimensional cell printed lock-key structure for oral soft and hard tissue regeneration

2021 ◽  
Author(s):  
Shihan Zhang ◽  
qing li ◽  
Peng Liu ◽  
Chunping Lin ◽  
Zhihui Tang ◽  
...  
Keyword(s):  
Tissue Regeneration ◽  
Three Dimensional ◽  
Hard Tissue ◽  
Dimensional Cell
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