Histologic Assessment of Alveolar Bone Remodeling Around Immediate Implants Placed in Single and Multiple Contiguous Extraction Sites

2014 ◽  
Vol 34 (3) ◽  
pp. 413-421 ◽  
Author(s):  
Abdulaziz Al-Rasheed ◽  
Munirah Al-Shabeeb ◽  
Nadir Babay ◽  
Fawad Javed ◽  
Mansour Al-Askar ◽  
...  
Keyword(s):  
Bone Remodeling ◽  
Alveolar Bone ◽  
Alveolar Bone Remodeling ◽  
Immediate Implants

Orthodontic Force–Induced BMAL1 in PDLCs Is a Vital Osteoclastic Activator

2021 ◽  
pp. 002203452110199
Author(s):  
Y. Xie ◽  
Q. Tang ◽  
S. Yu ◽  
W. Zheng ◽  
G. Chen ◽  
...  
Keyword(s):  
Bone Remodeling ◽  
Alveolar Bone ◽  
Tooth Movement ◽  
Orthodontic Tooth Movement ◽  
Nuclear Factor Κb ◽  
Periodontal Ligament Cells ◽  
Orthodontic Force ◽  
Periodontal Tissues ◽  
Alveolar Bone Remodeling ◽  
Biomechanical Stimuli

Orthodontic tooth movement (OTM) depends on periodontal ligament cells (PDLCs) sensing biomechanical stimuli and subsequently releasing signals to initiate alveolar bone remodeling. However, the mechanisms by which PDLCs sense biomechanical stimuli and affect osteoclastic activities are still unclear. This study demonstrates that the core circadian protein aryl hydrocarbon receptor nuclear translocator–like protein 1 (BMAL1) in PDLCs is highly involved in sensing and delivering biomechanical signals. Orthodontic force upregulates BMAL1 expression in periodontal tissues and cultured PDLCs in manners dependent on ERK (extracellular signal–regulated kinase) and AP1 (activator protein 1). Increased BMAL1 expression can enhance secretion of CCL2 (C-C motif chemokine 2) and RANKL (receptor activator of nuclear factor–κB ligand) in PDLCs, which subsequently promotes the recruitment of monocytes that differentiate into osteoclasts. The mechanistic delineation clarifies that AP1 induced by orthodontic force can directly interact with the BMAL1 promoter and activate gene transcription in PDLCs. Localized administration of the ERK phosphorylation inhibitor U0126 or the BMAL1 inhibitor GSK4112 suppressed ERK/AP1/BMAL1 signaling. These treatments dramatically reduced osteoclastic activity in the compression side of a rat orthodontic model, and the OTM rate was almost nonexistent. In summary, our results suggest that force-induced expression of BMAL1 in PDLCs is closely involved in controlling osteoclastic activities during OTM and plays a vital role in alveolar bone remodeling. It could be a useful therapeutic target for accelerating the OTM rate and controlling pathologic bone-remodeling activities.

Effects of sialoadenectomy and exogenous EGF on molar drift and orthodontic tooth movement in rats

1994 ◽  
Vol 266 (5) ◽  
pp. E731-E738 ◽  
Author(s):  
C. Dolce ◽  
J. Anguita ◽  
L. Brinkley ◽  
P. Karnam ◽  
M. Humphreys-Beher ◽  
...  
Keyword(s):  
Bone Formation ◽  
Bone Remodeling ◽  
Alveolar Bone ◽  
Tooth Movement ◽  
Orthodontic Tooth Movement ◽  
Alveolar Bone Remodeling ◽  
Tooth Roots ◽  
Epidermal Growth ◽  
Tetracycline Labeling ◽  
Distal Aspect

Effects on bone remodeling have been attributed to epidermal growth factor (EGF). Sialoadenectomy (SX) removes the major source of EGF in rodents and decreases both salivary and serum EGF levels. EGF effects on rat alveolar bone remodeling manifested by molar drift (MD) and orthodontic tooth movement (OTM) were examined using the following two approaches: 1) EGF depletion by SX and replacement by orally administered EGF (50 micrograms.animal-1.day-1); 2) sham rats supplemented with matching amounts of EGF. MD and OTM were measured using cephalometric radiographs; bone formation was measured histomorphometrically using tetracycline labeling. Normal MD was not detected after SX, and alveolar bone formation was significantly reduced both around the tooth and in nondental sites. Replacement EGF given to SX rats and supplemental EGF administered to sham rats changed the direction and enhanced the rate of MD. A mesially directed orthodontic force applied to the molars of SX animals increased bone formation on the distal aspect of the tooth roots. Supplemental EGF did not significantly affect OTM. EGF affects alveolar bone remodeling, as manifested clinically by alterations in normal maxillary MD.

The angiotensin converting enzyme 2/angiotensin-(1-7)/Mas Receptor axis as a key player in alveolar bone remodeling

Bone ◽  
2019 ◽  
Vol 128 ◽  
pp. 115041 ◽  
Author(s):  
Celso Martins Queiroz-Junior ◽  
Anna Clara Paiva Menezes Santos ◽  
Izabela Galvão ◽  
Giovanna Ribeiro Souto ◽  
Ricardo Alves Mesquita ◽  
...  
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Bone Remodeling ◽  
Alveolar Bone ◽  
Converting Enzyme ◽  
Angiotensin Converting Enzyme 2 ◽  
Mas Receptor ◽  
Alveolar Bone Remodeling

scholarly journals Bone Resorption Rate of Moved and Fixed Teeth during Alveolar Bone Remodeling by Orthodontic Treatment.

1998 ◽  
Vol 64 (626) ◽  
pp. 3888-3893
Author(s):  
Hajime MORIKAWA ◽  
Seiki YAMANAMI ◽  
Morimasa NISHIHIRA ◽  
Katsuyuki YAMAMOTO ◽  
Yoshiaki SATOH ◽  
...  
Keyword(s):  
Bone Resorption ◽  
Bone Remodeling ◽  
Orthodontic Treatment ◽  
Alveolar Bone ◽  
Resorption Rate ◽  
Alveolar Bone Remodeling ◽  
Bone Resorption Rate

Immunohistochemical localization of tenascin-C in rat periodontal ligament with reference to alveolar bone remodeling

2015 ◽  
Vol 91 (2) ◽  
pp. 196-206 ◽  
Author(s):  
Rei Sato ◽  
Hiroki Fukuoka ◽  
Tamaki Yokohama-Tamaki ◽  
Masaru Kaku ◽  
Shunichi Shibata
Keyword(s):  
Bone Remodeling ◽  
Periodontal Ligament ◽  
Alveolar Bone ◽  
Immunohistochemical Localization ◽  
Tenascin C ◽  
Alveolar Bone Remodeling

Impairment in physiological alveolar bone remodeling caused by lead poisoning

Bone ◽  
2011 ◽  
Vol 48 (6) ◽  
pp. S290
Author(s):  
P. Mitre ◽  
N. Soria ◽  
H. Meheris ◽  
J. Garat
Keyword(s):  
Bone Remodeling ◽  
Lead Poisoning ◽  
Alveolar Bone ◽  
Alveolar Bone Remodeling
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