Effects of Local Drug and Chemical Compound Delivery on Bone Regeneration Around Dental Implants in Animal Models: A Systematic Review and Meta-Analysis

2018 ◽  
Vol 33 (1) ◽  
pp. e1-e18 ◽  
Author(s):  
Ali Alenezi ◽  
Bruno Chrcanovic ◽  
Ann Wennerberg
Keyword(s):  
Systematic Review ◽  
Animal Models ◽  
Bone Regeneration ◽  
Dental Implants ◽  
Chemical Compound ◽  
Meta Analysis

scholarly journals The Impact of Bioceramic Scaffolds on Bone Regeneration in Preclinical In Vivo Studies: A Systematic Review

Materials ◽  
2020 ◽  
Vol 13 (7) ◽  
pp. 1500 ◽  
Author(s):  
Giulia Brunello ◽  
Sourav Panda ◽  
Lucia Schiavon ◽  
Stefano Sivolella ◽  
Lisa Biasetto ◽  
...  
Keyword(s):  
Systematic Review ◽  
Animal Models ◽  
Bone Regeneration ◽  
Bone Defect ◽  
Alveolar Bone ◽  
Meta Analysis ◽  
In Vivo Studies ◽  
Autogenous Bone ◽  
Grafting Materials ◽  
The Impact

Bioceramic scaffolds are appealing for alveolar bone regeneration, because they are emerging as promising alternatives to autogenous and heterogenous bone grafts. The aim of this systematic review is to answer to the focal question: in critical-sized bone defects in experimental animal models, does the use of a bioceramic scaffolds improve new bone formation, compared with leaving the empty defect without grafting materials or using autogenous bone or deproteinized bovine-derived bone substitutes? Electronic databases were searched using specific search terms. A hand search was also undertaken. Only randomized and controlled studies in the English language, published in peer-reviewed journals between 2013 and 2018, using critical-sized bone defect models in non-medically compromised animals, were considered. Risk of bias assessment was performed using the SYRCLE tool. A meta-analysis was planned to synthesize the evidence, if possible. Thirteen studies reporting on small animal models (six studies on rats and seven on rabbits) were included. The calvarial bone defect was the most common experimental site. The empty defect was used as the only control in all studies except one. In all studies the bioceramic materials demonstrated a trend for better outcomes compared to an empty control. Due to heterogeneity in protocols and outcomes among the included studies, no meta-analysis could be performed. Bioceramics can be considered promising grafting materials, though further evidence is needed.

Effects of sleep deprivation on maternal behaviour in animal models: A systematic review and meta‐analysis

2021 ◽  
Author(s):  
Gabriel N. Pires ◽  
Thainá B. Oliveira ◽  
Victoria F. F. Mello ◽  
Andréia G. Bezerra ◽  
Cathalijn H. C. Leenaars ◽  
...  
Keyword(s):  
Systematic Review ◽  
Animal Models ◽  
Sleep Deprivation ◽  
Meta Analysis ◽  
Maternal Behaviour

Clinical evidence on titanium–zirconium dental implants: a systematic review and meta-analysis

2016 ◽  
Vol 45 (7) ◽  
pp. 842-850 ◽  
Author(s):  
P. Altuna ◽  
E. Lucas-Taulé ◽  
J. Gargallo-Albiol ◽  
O. Figueras-Álvarez ◽  
F. Hernández-Alfaro ◽  
...  
Keyword(s):  
Systematic Review ◽  
Dental Implants ◽  
Clinical Evidence ◽  
Meta Analysis ◽  
Titanium Zirconium

scholarly journals Efficacy of Deferoxamine in Animal Models of Intracerebral Hemorrhage: A Systematic Review and Stratified Meta-Analysis

PLoS ONE ◽  
2015 ◽  
Vol 10 (5) ◽  
pp. e0127256 ◽  
Author(s):  
Han-Jin Cui ◽  
Hao-yu He ◽  
A-Li Yang ◽  
Hua-Jun Zhou ◽  
Cong Wang ◽  
...  
Keyword(s):  
Systematic Review ◽  
Animal Models ◽  
Intracerebral Hemorrhage ◽  
Meta Analysis
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