A Randomized Proof-of-Principle Bite Force Study of Two Experimental Denture Adhesives and a Commercially Available Adhesive

2018 ◽  
Vol 31 ◽  
pp. 351-358 ◽  
Author(s):  
Anto Jose ◽  
Roshan Varghese ◽  
Nima Roohpour ◽  
Stephen Mason ◽  
Ritika Jain ◽  
...  
Keyword(s):  
Bite Force ◽  
Denture Adhesives ◽  
Proof Of Principle

scholarly journals Effect of Denture Adhesives in New Complete Dentures During a Function

2018 ◽  
Vol 12 (1) ◽  
pp. 969-973
Author(s):  
Diego Mourão Guimarães ◽  
Érika Justo Marques ◽  
Giulia Cristina Deiró Almagro ◽  
Carolina Mayumi Iegami ◽  
Roberto Chaib Stegun ◽  
...  
Keyword(s):  
Health Assessment ◽  
Bite Force ◽  
Complete Denture ◽  
Test Material ◽  
Control Group ◽  
Self Perception ◽  
Denture Adhesive ◽  
Assessment Index ◽  
Masticatory Efficiency ◽  
Denture Adhesives

Background:Denture adhesives are often a matter of controversy. Patients seem to easily accept the use of denture adhesives, while professionals are more hesitant.Objective:The purpose of this study was to evaluate the self-perception, bite force and masticatory efficiency of complete denture wearers with denture adhesives.Methods:Fifteen complete denture wearers had their bite force measured by a gnathodynamometer in the molar region. Subjects also masticated 12 tablets of a chewable artificial test material for 35 masticatory cycles. The test material was washed, dried, sieved and weighed. Both tests were taken with and without the denture adhesive (Corega Ultra). The questionnaire Geriatric Oral Health Assessment Index (GOHAI) was applied to evaluate self-perception with dentures.Results and Conclusion:Masticatory efficiency and bite force for the control group (without denture adhesive) and for the group with denture adhesive presented no statistically significant differences (p= 0.2080 andp= 0.2489, respectively). Self-perception according to the GOHAI index was great for 13% of participants, 40% considered it regular and 47% evaluated it as bad. Within the limitations of this study, it can be concluded that the use of denture adhesive did not promote an improvement in bite force and masticatory efficiency. According to the GOHAI index, self-perception of the participants was classified as bad.

Zellersatztherapie beim Morbus Parkinson

2005 ◽  
Vol 24 (01) ◽  
pp. 36-40
Author(s):  
A. Storch ◽  
J. Schwarz
Keyword(s):  
Morbus Parkinson ◽  
Kontrollierte Studien ◽  
Proof Of Principle

ZusammenfassungDer Ersatz dopaminerger Neurone bei Patienten mit Morbus Parkinson bleibt eine attraktive Behandlungsstrategie. Die Implantation von embryonalem Mittelhirngewebe war die erste Therapie, die nicht nur den »Proof-of-Principle« in Tierversuchen lieferte, sondern auch Eingang in klinische Applikationen fand. 1987 wurde zunächst eine Reihe von kleinen offenen Studien mit sorgfältiger Patientenselektion gestartet, die sehr ermutigende Ergebnisse bei zumindest einem Teil der Patienten erbrachten. In den vergangenen Jahren wurden in den USA zwei doppelblinde, kontrollierte Studien abgeschlossen, deren Resultate eher enttäuschend blieben, da die primären Endpunkte (Besserung der Parkinson-Symptomatik im Off) keine signifikanten Unterschiede zeigten. Zudem wurden in beiden Studien 12 Stunden nach L-Dopa-Einnahme Dyskinesien beobachtet. Die Ursachen dieser unterschiedlichen Ergebnisse könnten in der Variabilität des Gewebes, relevanten Immunreaktionen und ungleichmäßiger Dopaminausschüttung im Striatum liegen. Zudem legen die ethischen Probleme bei der Gewinnung des Gewebes die Notwendigkeit anderer, besser standardisierter Gewebe nahe. Derzeit scheint es möglich, dass alternativ sowohl aus embryonalen als auch neuralen Stammzellen, vielleicht sogar aus körpereigenen mesenchymalen Stammzellen dopaminerge Neurone generiert werden könnten. Diese Zellen können über einen langen Zeitraum expandiert, ausreichend standardisiert und charakterisiert werden.

Enantioselective Multi-Component Cyclopropane Synthesis Enabled by Cu-Catalyzed Cyclopropene Carbometallation with Organoboron Reagent

2018 ◽  
Author(s):  
Zhanyu Li ◽  
Mengru Zhang ◽  
Yu Zhang ◽  
Shuang Liu ◽  
Jinbo Zhao ◽  
...  
Keyword(s):  
Carbon Source ◽  
Stereoselective Synthesis ◽  
Organometallic Reagents ◽  
Preliminary Results ◽  
Quaternary Center ◽  
Chiral Centers ◽  
Substituted Cyclopropanes ◽  
Proof Of Principle

Deployment of organoboron in lieu of the strongly basic <br>organometallic reagents as carbon source in Cu-catalyzed <br>cyclopropene carbometallation opens unprecedented three-<br>component reactivity for stereoselective synthesis of poly-substituted cyclopropanes. A proof-of-principle demonstration of this novel carbometallation strategy is presented herein for a highly convergent access to poly-substituted aminocyclopropane framework via <br>carboamination. Preliminary results on asymmetric desymmetrization with commercial bisphosphine ligands attained high levels of enantioselection, offering a straightforward access to enantioenriched aminocyclopropanes bearing all-three chiral centers, including an all-carbon quaternary center. This strategy may underpin a host of novel synthetic protocols for poly-substituted cyclopropanes. <br>

Covalent-Fragment Screening of Brd4 Identifies a Ligandable Site Orthogonal to the Acetyl-Lysine Binding Sites

2019 ◽  
Author(s):  
Michael Olp ◽  
Daniel Sprague ◽  
Stefan Kathman ◽  
Ziyang Xu ◽  
Alexandar Statsyuk ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Binding Site ◽  
Binding Sites ◽  
Computational Prediction ◽  
Chemical Probes ◽  
Computational Docking ◽  
Fragment Screening ◽  
Covalent Inhibitors ◽  
Bet Protein ◽  
Proof Of Principle

<p>Brd4, a member of the bromodomain and extraterminal domain (BET) family, has emerged as a promising epigenetic target in cancer and inflammatory disorders. All reported BET family ligands bind within the bromodomain acetyl-lysine binding sites and competitively inhibit BET protein interaction with acetylated chromatin. Alternative chemical probes that act orthogonally to the highly-conserved acetyl-lysine binding sites may exhibit selectivity within the BET family and avoid recently reported toxicity in clinical trials of BET bromodomain inhibitors. Here, we report the first identification of a ligandable site on a bromodomain outside the acetyl-lysine binding site. Inspired by our computational prediction of hotspots adjacent to non-homologous cysteine residues within the <i>C</i>-terminal Brd4 bromodomain (Brd4-BD2), we performed a mid-throughput mass spectrometry screen to identify cysteine-reactive fragments that covalently and selectively modify Brd4. Subsequent mass spectrometry, NMR and computational docking analyses of electrophilic fragment hits revealed a novel ligandable site near Cys356 that is unique to Brd4 among all human bromodomains. This site is orthogonal to the Brd4-BD2 acetyl-lysine binding site as Cys356 modification did not impact binding of the pan-BET bromodomain inhibitor JQ1 in fluorescence polarization assays. Finally, we tethered covalent fragments to JQ1 and performed NanoBRET assays to provide proof of principle that this orthogonal site can be covalently targeted in intact human cells. Overall, we demonstrate the potential of targeting sites orthogonal to bromodomain acetyl-lysine binding sites to develop bivalent and covalent inhibitors that displace Brd4 from chromatin.</p>

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