scholarly journals Necrobiosis Lipoidica: Atypical Presentation in a Diabetic Girl

2021 ◽  
pp. 547-552
Author(s):  
Meshal M. Alhameedy
Keyword(s):  
Atypical Presentation ◽  
Necrobiosis Lipoidica ◽  
Childhood Onset ◽  
Upper Arm

Necrobiosis lipoidica (NL) is a chronic granulomatous idiopathic disorder. It usually presents as yellow-brown, atrophic, telangiectatic plaques with an elevated violaceous rim, typically in the pretibial region of both extremities with and without ulceration [1, 2]. There are few reported cases of childhood-onset NL in atypical locations. We report a case of type 1 diabetic 13-year-old girl who developed yellow atrophic plaque with telangiectasia on the extensor aspect of her upper arm.

Transition and beyond in childhood onset type 1 diabetes

2014 ◽  
Author(s):  
Suma Uday ◽  
James Yong ◽  
Fiona Campbell ◽  
Ramzi Ajjan
Keyword(s):  
Type 1 Diabetes ◽  
Childhood Onset ◽  
Onset Type

scholarly journals Low Incidence of End-Stage Renal Disease in Childhood-Onset Type 1 Diabetes Followed for Up to 42 Years

Diabetes Care ◽  
2017 ◽  
Vol 41 (3) ◽  
pp. 420-425 ◽  
Author(s):  
Vibeke Gagnum ◽  
Maryam Saeed ◽  
Lars C. Stene ◽  
Torbjørn Leivestad ◽  
Geir Joner ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
Childhood Onset ◽  
Onset Type ◽  
Low Incidence ◽  
Stage Renal Disease ◽  
End Stage

scholarly journals Mortality in patients with childhood-onset type 1 diabetes in Finland, Estonia, and Lithuania: follow-up of nationwide cohorts

Diabetes Care ◽  
2000 ◽  
Vol 23 (3) ◽  
pp. 290-294 ◽  
Author(s):  
T. Podar ◽  
A. Solntsev ◽  
A. Reunanen ◽  
B. Urbonaite ◽  
R. Zalinkevicius ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Childhood Onset ◽  
Onset Type

scholarly journals Insulin micro-secretion in Type 1 diabetes and related microRNA profiles

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Andrzej S. Januszewski ◽  
Yoon Hi Cho ◽  
Mugdha V. Joglekar ◽  
Ryan J. Farr ◽  
Emma S. Scott ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Cross Sectional Study ◽  
Diabetes Duration ◽  
Adult Onset ◽  
Sectional Study ◽  
Childhood Onset ◽  
Cross Sectional ◽  
C Peptide ◽  
Adult Onset Diabetes

AbstractThe aim of this cross-sectional study was to compare plasma C-peptide presence and levels in people without diabetes (CON) and with Type 1 diabetes and relate C-peptide status to clinical factors. In a subset we evaluated 50 microRNAs (miRs) previously implicated in beta-cell death and associations with clinical status and C-peptide levels. Diabetes age of onset was stratified as adult (≥ 18 y.o) or childhood (< 18 y.o.), and diabetes duration was stratified as ≤ 10 years, 10–20 years and > 20 years. Plasma C-peptide was measured by ultrasensitive ELISA. Plasma miRs were quantified using TaqMan probe-primer mix on an OpenArray platform. C-peptide was detectable in 55.3% of (n = 349) people with diabetes, including 64.1% of adults and 34.0% of youth with diabetes, p < 0.0001 and in all (n = 253) participants without diabetes (CON). C-peptide levels, when detectable, were lower in the individuals with diabetes than in the CON group [median lower quartile (LQ)–upper quartile (UQ)] 5.0 (2.6–28.7) versus 650.9 (401.2–732.4) pmol/L respectively, p < 0.0001 and lower in childhood versus adult-onset diabetes [median (LQ–UQ) 4.2 (2.6–12.2) pmol/L vs. 8.0 (2.3–80.5) pmol/L, p = 0.02, respectively]. In the childhood-onset group more people with longer diabetes duration (> 20 years) had detectable C-peptide (60%) than in those with shorter diabetes duration (39%, p for trend < 0.05). Nine miRs significantly correlated with detectable C-peptide levels in people with diabetes and 16 miRs correlated with C-peptide levels in CON. Our cross-sectional study results are supportive of (a) greater beta-cell function loss in younger onset Type 1 diabetes; (b) persistent insulin secretion in adult-onset diabetes and possibly regenerative secretion in childhood-onset long diabetes duration; and (c) relationships of C-peptide levels with circulating miRs. Confirmatory clinical studies and related basic science studies are merited.

Atypical presentation of necrobiosis lipoidica in a pediatric patient

2018 ◽  
Vol 36 (1) ◽  
Author(s):  
Ezgi Özkur ◽  
Seyhan Ö. Hasçiçek ◽  
İlknur Kıvanç Altunay
Keyword(s):  
Pediatric Patient ◽  
Atypical Presentation ◽  
Necrobiosis Lipoidica

scholarly journals Infant Growth and Risk of Childhood-Onset Type 1 Diabetes in Children From 2 Scandinavian Birth Cohorts

2015 ◽  
Vol 169 (12) ◽  
pp. e153759 ◽  
Author(s):  
Maria C. Magnus ◽  
Sjurdur F. Olsen ◽  
Charlotta Granström ◽  
Geir Joner ◽  
Torild Skrivarhaug ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Infant Growth ◽  
Birth Cohorts ◽  
Childhood Onset ◽  
Onset Type

scholarly journals A misdiagnosed myasthenia gravis with anti-muscle-specific tyrosine kinase antibodies with possible childhood onset

2015 ◽  
Vol 72 (7) ◽  
pp. 639-641 ◽  
Author(s):  
Ana Nikolic ◽  
Dragana Lavrnic ◽  
Ivana Basta ◽  
Dimitrije Nikolic ◽  
Slobodan Apostolski
Keyword(s):  
Tyrosine Kinase ◽  
Myasthenia Gravis ◽  
Spontaneous Recovery ◽  
Atypical Presentation ◽  
Childhood Onset ◽  
Repetitive Nerve Stimulation ◽  
Fisher Syndrome ◽  
Significant Decrement ◽  
Cyclosporine Therapy ◽  
Swallowing Difficulties

Introduction. Childhood onset myasthenia gravis associated with anti-muscle-specific tyrosine kinase antibodies is very rare and atypical in presentation. Case report. As a baby, the pre-sented patient was choking and sleeping with open eyes. She had weak cry and breathing difficulties. In childhood, there were frequent falls and fluctuating swallowing difficulties. At the age of 19 she was misdiagnosed with Miller Fisher syndrome due to the presence of diplopia, ataxia and hyporeflexia with spontaneous recovery. Repetitive nerve stimulation test was normal. Four years later, after several relapses, there was significant decrement on facial muscles. Neostigmine test was negative, provoking muscle fasciculations. Serum anti-muscle-specific tyrosine kinase antibodies were positive. With cyclosporine therapy she achieved the minimal manifestations status. Conclusion. The presented case confirms that childhood onset myasthenia gravis associated with anti-muscle-specific tyrosine kinase antibodies is often with atypical presentation and spontaneous remissions, so it could be easily misdiagnosed.

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