Correlation between NEN bone metastasis performance and tumor proliferation: 112 cases of [68Ga]Ga-DOTA-TATE results analysis

2021 ◽  
Author(s):  
Qing Xie ◽  
Ming Lu ◽  
Shizhen Zhai ◽  
Rui Guo ◽  
Changzhi Du ◽  
...  
Keyword(s):  
Lymph Node ◽  
Bone Metastasis ◽  
Negative Correlation ◽  
Lymph Node Metastases ◽  
Final Analysis ◽  
Proliferation Index ◽  
Neuroendocrine Neoplasm ◽  
Ki 67 ◽  
Normal Bone ◽  
Node Metastases

Purpose: To analyze neuroendocrine neoplasm (NEN) bone metastasis (BM) and Gallium-68 (68Ga)-DOTA-TATE performance and to explore their correlation with the immunohistochemical proliferation index (Ki-67). Procedures: A total of 112 patients with BMs were screened from 1082 NEN patients who underwent [68Ga]Ga-DOTA-TATE imaging. All patients had pathological results, and BMs were affirmed by clinical/imaging follow-up of and/or histopathology. The maximum standard uptake value (SUVmax) ratio of BM to normal bone determined for each patient was used in the final analysis. Results: The incidence rate of BMs in NENs was 10.35%. BMs occurred in the spine (75%), pelvis (72.3%), ribs (58%), clavicles and scapulae (41.1%), limbs (37.5%) and skull (28.6%). Most cases were associated with liver metastases (70.5%) and lymph node metastases (65.2%) simultaneously. The SUVmax ratio of G3b (median ratio=3.77, Ki-67>55%) was significantly lower than that of G1 (11.43, Ki-67≤2%) and G2a (11.15, 3%≤Ki-67≤10%) separately P<0.05), while no differences were found for the G2b (8.5, 11%≤Ki-67≤55%) and G3a (6.64, Ki-67>55%) groups. In the total patients there was a significant negative correlation between the SUVmax ratio of BMs to normal bone and Ki-67 (r=-0.267, P<0.01). According to the changes in bone density on computed tomography (CT) scans, the cases were divided into four groups: osteogenesis, osteolysis, no change and a mixed group (median Ki-67: 6.5%, 15%, 12%, and 22.5%). The Ki-67 values were significantly different between the osteogenesis group and the other groups (P<0.05). Conclusion: BM is present in 10.35 % of NEN patients, and most have simultaneous liver and/or lymph node metastases. The occurrence of osteogenesis indicates relativity good differentiation and there is a negative correlation between SUVmax ratio of BMs and NEN proliferation.

Cytokeratin 7 negative invasive breast carcinoma: clinicopathological and immunohistochemical analysis of 14 cases with clinical follow-up

2015 ◽  
Vol 68 (6) ◽  
pp. 484-487 ◽  
Author(s):  
Neda A Moatamed ◽  
Annie Wu ◽  
Khaled Sarah ◽  
Sophia K Apple
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastases ◽  
Proliferation Index ◽  
Axillary Lymph ◽  
Cytokeratin 7 ◽  
Ki 67 ◽  
Her 2 ◽  
Node Metastases ◽  
Work Up

Cytokeratin 7 (CK 7) negative breast tumours are reported to occur rarely. We studied 14 CK 7 negative cases of primary invasive ductal carcinoma (IDC) detected during sentinel lymph node metastases work-up and immunohistochemistry panel in the work-up of metastatic carcinoma of unknown origin. Axillary lymph node metastases were present in seven patients (50%). Oestrogen receptor (ER) was strongly positive in all cases: progesterone receptor in 78%, Her-2/neu in 7% and high proliferation index with Ki-67 >20% was seen in 71% of the cases.Metastatic and/or recurrence were found in 8 of 14 patients (57%) with the mean clinical follow-up of 55 months. Metastatic sites include multiple bones, brain, spinal cord, liver, pancreas, ovary, lung, lymph node other than ipsilateral axillary and skin. 12 of 14 patients received adjuvant chemotherapy. All 14 patients received hormonal therapy and radiation therapy. Morphologically, IDC with neuroendocrine features was noted in 57%. Synaptophysin stain was positive in 57% and chromogranin was positive in 21% of the cases. In conclusion, these CK 7 negative breast carcinomas were ER positive, mostly Her-2/neu negative, had high Ki-67 and frequently showed neuroendocrine differentiation. More than half of these cases had a poor outcome.

scholarly journals Factors correlating with lymph node metastases in patients with T1 ductal invasive breast cancer

2006 ◽  
Vol 14 (1-2) ◽  
pp. 19-22 ◽  
Author(s):  
Tatjana Ivkovic-Kapicl ◽  
Milana Panjkovic ◽  
Dejan Nincic ◽  
Slavica Knezevic-Usaj
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Protein Expression ◽  
Lymph Node Metastases ◽  
Tumor Size ◽  
P53 Protein ◽  
Proliferation Index ◽  
Ki 67 ◽  
Receptor Status ◽  
Node Metastases

BACKGROUND: Identification of reliable predictors of axillary lymph node metastases (ALNM) may be useful in selecting appropriate management for patients with T1-size breast cancer. This study was undertaken to determine the association between ALNM and several variables, including age, tumor size, grade, estrogen receptor status, progesterone receptor status, p53 and c-erbB2 protein expression, and Ki-67 proliferative index. METHODS: In a retrospective study, 74 patients with pT1b and pT1c ductal invasive breast carcinoma and with known nodal status were analyzed. The size of the infiltrating tumor was microscopically evaluated. The histological grading was performed using the modified criteria of Bloom and Richardson, as described by Elston and Ellis. The immunophenotype of the tumor was determined as: the expression of estrogen (ER) and progesterone (PR) receptors, p53, c-erbB2 and Ki-67. The patients were grouped by age as follows: <50, 50-70, and >70 years old. RESULTS: Twenty six patients (35%) were node positive. Tumor size was related directly to nodal positivity. Nodal positivity was significantly related to negative PR status, p53 protein overexpression and high Ki-67 index (p<0.05). No significant association was found between nodal positivity and patient age, tumor grade, ER status, and c-erbB2 expression. CONCLUSION: These data suggest that PR status, Ki-67 proliferation index, and p53 protein expression might provide additional information to the lymph node status in T1 ductal breast carcinomas.

scholarly journals Gastroenteropancreatic neuroendocrine tumor of the accessory papilla of the duodenum: a case report

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Kosei Takagi ◽  
Yuzo Umeda ◽  
Ryuichi Yoshida ◽  
Kazuhiro Yoshida ◽  
Kazuya Yasui ◽  
...  
Keyword(s):  
Lymph Node ◽  
Neuroendocrine Tumor ◽  
Lymph Node Metastases ◽  
Treatment Strategy ◽  
Gastroenteropancreatic Neuroendocrine Tumors ◽  
Ki 67 ◽  
Invasive Approach ◽  
Robotic Pancreatoduodenectomy ◽  
Estimated Blood Loss ◽  
Node Metastases

Abstract Background Contrary to the increasing incidence of gastroenteropancreatic neuroendocrine tumors (GEP-NETs), GEP-NETs of the accessory papilla of the duodenum are extremely rare. Furthermore, there have been no recommendations regarding the treatment strategy for GEP-NETs of the accessory papilla of the duodenum. We present a case of GEP-NET of the accessory papilla of the duodenum successfully treated with robotic pancreatoduodenectomy. Case presentation A case of a 70-year-old complaining of no symptoms was diagnosed with GEP-NET of the accessory papilla of the duodenum. A 8-mm tumor was located at the submucosal layer with a biopsy demonstrating a neuroendocrine tumor grade 1. The patient underwent robotic pancreatoduodenectomy as curative resection for the tumor. The total operative time was 406 min with an estimated blood loss of 150 mL. The histological examination revealed a well-differentiated neuroendocrine tumor with low Ki-67 index (< 1%). In the posterior areas of the pancreas, the lymph node metastases were detected. The patient was followed up for 6 months with no recurrence postoperatively. Conclusions Considering the potential risks of the lymph node metastases, the standard treatment strategy for GEP-NETs of the accessory papilla of the duodenum should be radical resection with pancreatoduodenectomy. Minimally invasive approach can be the alternative to the conventional open surgery.

scholarly journals ERα and ERβ expression in correlation with Ki-67, Bcl-2 and Bak in primary tumors and lymph node metastases of breast cancer: The effect of pre-operative chemotherapy

2010 ◽  
Vol 1 (6) ◽  
pp. 1067-1071 ◽  
Author(s):  
LUIZA KANCZUGA-KODA ◽  
MARIUSZ KODA ◽  
JAKUB TOMASZEWSKI ◽  
KATARZYNA JARZABEK ◽  
JOANNA LOTOWSKA ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Lymph Node Metastases ◽  
Ki 67 ◽  
Primary Tumors ◽  
Node Metastases

Predictors of sentinel lymph node metastases in breast cancer-radioactivity and Ki-67

The Breast ◽  
2016 ◽  
Vol 30 ◽  
pp. 87-91 ◽  
Author(s):  
Fabinshy Thangarajah ◽  
Wolfram Malter ◽  
Stefanie Hamacher ◽  
Matthias Schmidt ◽  
Stefan Krämer ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Lymph Node Metastases ◽  
Ki 67 ◽  
Node Metastases

scholarly journals Clinical significance of proliferation index and E-cadherin expression in colorectal adenocarcinoma

2021 ◽  
pp. 55-55
Author(s):  
Janko Zujovic ◽  
Milena Vuletic ◽  
Miroslav Stojanovic ◽  
Ranko Lazovic ◽  
Nebojsa Djordjevic ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Lymph Node ◽  
Blood Vessel ◽  
Lymph Node Metastases ◽  
Perineural Invasion ◽  
Distant Metastases ◽  
Proliferation Index ◽  
Blood Vessel Invasion ◽  
Node Metastases ◽  
E Cadherin

Introduction/Objective. The aim of this study is to examine the association of E-cadherin expression and high proliferation index (proIDX) with clinical and pathological indicators of colorectal cancer progression. Methods. The biopsy of 72 patients, obtained by resection of colorectal cancer, was routinely processed at the Institute of Pathology of the Clinical Centre of Montenegro, embedded in paraffin and archived. Based on the archived pathohistological reports, two study groups were formed: the first group (n = 72) consisted of operative biopsies of colorectal cancer, and the control group (n = 72) consisted of biopsies of adjacent non-tumor tissue. Routine hematoxylin-eosin and immunohistochemical ABC method with anti-Ki67 and anti-E-cadherin antibodies was applied on. After quantification of the results for statistical tests, the software package SPSS for Windows (19.0) was used. Results. In colorectal carcinoma, we observed a significant association of proIDX with pT stage, lymph and blood vessel invasion, perineural invasion, lymph node metastases and distant metastases, and Astler-Coller stage tumor disease. We also observed that the absence of E-cadherin was significantly associated with pT stage, lymph and blood vessel invasion, perineural invasion with lymph node metastases, distant metastases, with C2 and D Astler-Coller tumor stage. E-cadherin expression is associated with proIDX with a significantly high, negative correlation coefficient. Conclusion. Our results indicate that it is possible to differentiate patients into groups with a higher or lower risk of developing metastatic disease, based on the expression of Ki67 and E-cadherin.

Expression of ERα, ERβ and Ki-67 in primary tumors and lymph node metastases in breast cancer

2004 ◽  
Author(s):  
Mariusz Koda ◽  
Stanislaw Sulkowski ◽  
Luiza Kanczuga-Koda ◽  
Eva Surmacz ◽  
Mariola Sulkowska
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Lymph Node Metastases ◽  
Ki 67 ◽  
Primary Tumors ◽  
Node Metastases

scholarly journals The effect of chemotherapy on Ki-67, Bcl-2 and Bak expression in primary tumors and lymph node metastases of breast cancer

2007 ◽  
Author(s):  
Mariusz Koda ◽  
Mariola Sulkowska ◽  
Luiza Kanczuga-Koda ◽  
Jakub Tomaszewski ◽  
Waldemar Kucharczuk ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Lymph Node Metastases ◽  
Ki 67 ◽  
Primary Tumors ◽  
Node Metastases
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