scholarly journals Factors correlating with lymph node metastases in patients with T1 ductal invasive breast cancer

2006 ◽  
Vol 14 (1-2) ◽  
pp. 19-22 ◽  
Author(s):  
Tatjana Ivkovic-Kapicl ◽  
Milana Panjkovic ◽  
Dejan Nincic ◽  
Slavica Knezevic-Usaj
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Protein Expression ◽  
Lymph Node Metastases ◽  
Tumor Size ◽  
P53 Protein ◽  
Proliferation Index ◽  
Ki 67 ◽  
Receptor Status ◽  
Node Metastases

BACKGROUND: Identification of reliable predictors of axillary lymph node metastases (ALNM) may be useful in selecting appropriate management for patients with T1-size breast cancer. This study was undertaken to determine the association between ALNM and several variables, including age, tumor size, grade, estrogen receptor status, progesterone receptor status, p53 and c-erbB2 protein expression, and Ki-67 proliferative index. METHODS: In a retrospective study, 74 patients with pT1b and pT1c ductal invasive breast carcinoma and with known nodal status were analyzed. The size of the infiltrating tumor was microscopically evaluated. The histological grading was performed using the modified criteria of Bloom and Richardson, as described by Elston and Ellis. The immunophenotype of the tumor was determined as: the expression of estrogen (ER) and progesterone (PR) receptors, p53, c-erbB2 and Ki-67. The patients were grouped by age as follows: <50, 50-70, and >70 years old. RESULTS: Twenty six patients (35%) were node positive. Tumor size was related directly to nodal positivity. Nodal positivity was significantly related to negative PR status, p53 protein overexpression and high Ki-67 index (p<0.05). No significant association was found between nodal positivity and patient age, tumor grade, ER status, and c-erbB2 expression. CONCLUSION: These data suggest that PR status, Ki-67 proliferation index, and p53 protein expression might provide additional information to the lymph node status in T1 ductal breast carcinomas.

scholarly journals ERα and ERβ expression in correlation with Ki-67, Bcl-2 and Bak in primary tumors and lymph node metastases of breast cancer: The effect of pre-operative chemotherapy

2010 ◽  
Vol 1 (6) ◽  
pp. 1067-1071 ◽  
Author(s):  
LUIZA KANCZUGA-KODA ◽  
MARIUSZ KODA ◽  
JAKUB TOMASZEWSKI ◽  
KATARZYNA JARZABEK ◽  
JOANNA LOTOWSKA ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Lymph Node Metastases ◽  
Ki 67 ◽  
Primary Tumors ◽  
Node Metastases

The relationship of p53 Protein and lymph node metastases in invasive breast cancer

Surgery Today ◽  
1994 ◽  
Vol 24 (6) ◽  
pp. 512-517 ◽  
Author(s):  
Masakuni Noguchi ◽  
Hirohisa Kitagawa ◽  
Kazuo Kinoshita ◽  
Michael Thomas ◽  
Itsuo Miyazaki ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Invasive Breast Cancer ◽  
Lymph Node Metastases ◽  
P53 Protein ◽  
Node Metastases ◽  
Relationship Of ◽  
The Relationship

Predictors of sentinel lymph node metastases in breast cancer-radioactivity and Ki-67

The Breast ◽  
2016 ◽  
Vol 30 ◽  
pp. 87-91 ◽  
Author(s):  
Fabinshy Thangarajah ◽  
Wolfram Malter ◽  
Stefanie Hamacher ◽  
Matthias Schmidt ◽  
Stefan Krämer ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Lymph Node Metastases ◽  
Ki 67 ◽  
Node Metastases

Expression of ERα, ERβ and Ki-67 in primary tumors and lymph node metastases in breast cancer

2004 ◽  
Author(s):  
Mariusz Koda ◽  
Stanislaw Sulkowski ◽  
Luiza Kanczuga-Koda ◽  
Eva Surmacz ◽  
Mariola Sulkowska
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Lymph Node Metastases ◽  
Ki 67 ◽  
Primary Tumors ◽  
Node Metastases

scholarly journals The effect of chemotherapy on Ki-67, Bcl-2 and Bak expression in primary tumors and lymph node metastases of breast cancer

2007 ◽  
Author(s):  
Mariusz Koda ◽  
Mariola Sulkowska ◽  
Luiza Kanczuga-Koda ◽  
Jakub Tomaszewski ◽  
Waldemar Kucharczuk ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Lymph Node Metastases ◽  
Ki 67 ◽  
Primary Tumors ◽  
Node Metastases

Cytokeratin 7 negative invasive breast carcinoma: clinicopathological and immunohistochemical analysis of 14 cases with clinical follow-up

2015 ◽  
Vol 68 (6) ◽  
pp. 484-487 ◽  
Author(s):  
Neda A Moatamed ◽  
Annie Wu ◽  
Khaled Sarah ◽  
Sophia K Apple
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastases ◽  
Proliferation Index ◽  
Axillary Lymph ◽  
Cytokeratin 7 ◽  
Ki 67 ◽  
Her 2 ◽  
Node Metastases ◽  
Work Up

Cytokeratin 7 (CK 7) negative breast tumours are reported to occur rarely. We studied 14 CK 7 negative cases of primary invasive ductal carcinoma (IDC) detected during sentinel lymph node metastases work-up and immunohistochemistry panel in the work-up of metastatic carcinoma of unknown origin. Axillary lymph node metastases were present in seven patients (50%). Oestrogen receptor (ER) was strongly positive in all cases: progesterone receptor in 78%, Her-2/neu in 7% and high proliferation index with Ki-67 >20% was seen in 71% of the cases.Metastatic and/or recurrence were found in 8 of 14 patients (57%) with the mean clinical follow-up of 55 months. Metastatic sites include multiple bones, brain, spinal cord, liver, pancreas, ovary, lung, lymph node other than ipsilateral axillary and skin. 12 of 14 patients received adjuvant chemotherapy. All 14 patients received hormonal therapy and radiation therapy. Morphologically, IDC with neuroendocrine features was noted in 57%. Synaptophysin stain was positive in 57% and chromogranin was positive in 21% of the cases. In conclusion, these CK 7 negative breast carcinomas were ER positive, mostly Her-2/neu negative, had high Ki-67 and frequently showed neuroendocrine differentiation. More than half of these cases had a poor outcome.

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