Longitudinal Erythro-Leukoxanthonychia Developing after PUVA Therapy

2021 ◽  
pp. 1-4
Author(s):  
Mohamed Hussein Medhat El-Komy ◽  
Basma Gaballa ◽  
Mona R.E. Abdel-Halim
Keyword(s):  
Puva Therapy

Malignant melanoma after psoralen and ultraviolet A (PUVA) therapy

1998 ◽  
Vol 138 (6) ◽  
pp. 1100-1101 ◽  
Author(s):  
Wolf ◽  
SchOllnast ◽  
Hofer ◽  
Smolle ◽  
Kerl
Keyword(s):  
Malignant Melanoma ◽  
Puva Therapy ◽  
Ultraviolet A

Woronoff's rings with PUVA therapy

1979 ◽  
Vol 115 (1) ◽  
pp. 105-105 ◽  
Author(s):  
A. P. Warin
Keyword(s):  
Puva Therapy

Study on Switch from High-concentration to Low-concentration Tacalcitol during Concomitant Use of Bath-PUVA Therapy

2007 ◽  
Vol 69 (6) ◽  
pp. 660-664
Author(s):  
Maki IWAKIRI ◽  
Noriko YASAKA ◽  
Kotaro ITO ◽  
Yuichi YOSHIDA ◽  
Yumiko KUBOTA ◽  
...  
Keyword(s):  
Puva Therapy ◽  
High Concentration ◽  
Low Concentration

Combination of Local PUVA-Therapy and Interferon Alpha-2A in the Treatment of Tumoral Stage Mycosis Fungoides

Dermatology ◽  
1996 ◽  
Vol 193 (1) ◽  
pp. 74-75
Author(s):  
N. Delpuget-Berlin ◽  
P. Bernard ◽  
C. Bedane ◽  
P.-M. Dang ◽  
J.-M. Bonnetblanc
Keyword(s):  
Mycosis Fungoides ◽  
Interferon Alpha ◽  
Puva Therapy

An Evaluation of PUVA-Therapy for Alopecia areata

Dermatology ◽  
1984 ◽  
Vol 168 (5) ◽  
pp. 250-252 ◽  
Author(s):  
W.W. van der Schaar ◽  
J.H. Sillevis Smitt
Keyword(s):  
Alopecia Areata ◽  
Puva Therapy

Dose Measurement in PUVA Therapy

Dermatology ◽  
1979 ◽  
Vol 159 (2) ◽  
pp. 176-179
Author(s):  
J. De Bersaques
Keyword(s):  
Dose Measurement ◽  
Puva Therapy

Celery soup causing severe phototoxity during PUVA therapy

1996 ◽  
Vol 135 (2) ◽  
pp. 334-334 ◽  
Author(s):  
M. J. Boffa ◽  
E. Gilmour ◽  
R. D. Ead
Keyword(s):  
Puva Therapy

THE RELATIONSHIP OF SKIN CANCER TO PUVA THERAPY IN AUSTRALIA

1981 ◽  
Vol 22 (3) ◽  
pp. 100-103 ◽  
Author(s):  
E. Lobel ◽  
K. Paver ◽  
R. King ◽  
J. Le Guay ◽  
K. Poyzer ◽  
...  
Keyword(s):  
Skin Cancer ◽  
Puva Therapy ◽  
Relationship Of ◽  
The Relationship

scholarly journals PUVA bath therapy strongly suppresses immunological and epidermal activation in psoriasis: a possible cellular basis for remittive therapy.

1994 ◽  
Vol 180 (1) ◽  
pp. 283-296 ◽  
Author(s):  
V P Vallat ◽  
P Gilleaudeau ◽  
L Battat ◽  
J Wolfe ◽  
R Nabeya ◽  
...  
Keyword(s):  
T Cells ◽  
Growth Factor ◽  
Interleukin 2 ◽  
Epidermal Keratinocytes ◽  
Therapeutic Effects ◽  
Sustained Remission ◽  
Puva Therapy ◽  
Cellular Basis ◽  
Bath Therapy ◽  
Puva Treatment

Psoriasis is characterized by alterations in both the epidermis and dermis of the skin. Epidermal keratinocytes display marked proliferative activation and differentiate along an "alternate" or "regenerative" pathway, while the dermis becomes infiltrated with leukocytes, particularly interleukin 2 (IL-2) receptor-bearing "activated" T cells. Psoralens, administered by the oral route, have therapeutic effects in psoriasis when photochemically activated by ultraviolet A light (PUVA therapy). Recently psoralen bath therapy has been introduced to more effectively deliver this agent to the diseased skin. We have correlated the efficacy of PUVA bath therapy with its effects on specific molecular and cellular parameters of disease, in 10 consecutive patients with recalcitrant psoriasis. Rapid clearing of lesions occurred in 8 out of 10 patients. Biopsies were taken from lesional and nonlesional skin before and after a single round of therapy, and observation was continued in our Clinical Research Center at The Rockefeller University. Enumeration of cycling keratinocytes with the Ki-67 monoclonal antibody showed that PUVA reduced cell proliferation by 73%. The pathological increase in insulin-like growth factor 1 (IGF-1) receptors was reversed, whereas epidermal growth factor (EGF) receptors, which are also increased in psoriasis, remained unchanged. Keratinocyte proteins that are expressed in abnormal sites of the epidermis during psoriasis, i.e., keratin 16, filaggrin, and involucrin, were, after PUVA treatment, localized to their normal sites. Epidermal and dermal T-lymphocytes (CD3+), as well as CD4+, CD8+, and IL-2 receptor+ subsets, were strongly suppressed by PUVA, with virtual elimination of IL-2 receptor+ T cells in some patients. Consistent with diminished lymphocyte activation, HLA-DR expression by epidermal keratinocytes was markedly reduced in treated skin. In comparison to cyclosporine treatment of psoriasis, PUVA therapy leads to more complete reversal of pathological epidermal and lymphocytic activation, changes which we propose to be the cellular basis for a more sustained remission of disease after PUVA treatment.

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