Combination of Local PUVA-Therapy and Interferon Alpha-2A in the Treatment of Tumoral Stage Mycosis Fungoides

Dermatology ◽  
1996 ◽  
Vol 193 (1) ◽  
pp. 74-75
Author(s):  
N. Delpuget-Berlin ◽  
P. Bernard ◽  
C. Bedane ◽  
P.-M. Dang ◽  
J.-M. Bonnetblanc
Keyword(s):  
Mycosis Fungoides ◽  
Interferon Alpha ◽  
Puva Therapy

scholarly journals Bath‐water PUVA Therapy with 8‐Methoxypsoralen in Mycosis Fungoides

2005 ◽  
Vol 85 (4) ◽  
pp. 329-332 ◽  
Author(s):  
Florian Weber ◽  
Matthias Schmuth ◽  
Norbert Sepp ◽  
Peter Fritsch
Keyword(s):  
Mycosis Fungoides ◽  
Puva Therapy ◽  
Bath Water

scholarly journals Efficiency of phototherapy in patients with mycosis fungoides: preliminary results of a comparative non-randomized study

2020 ◽  
Vol 96 (5) ◽  
pp. 24-30
Author(s):  
A. E. Karamova ◽  
M. B. Zhilova ◽  
L. F. Znamenskaya ◽  
A. A. Vorontsova
Keyword(s):  
Mycosis Fungoides ◽  
Assessment Tool ◽  
Research Evaluation ◽  
Therapy Group ◽  
Randomized Study ◽  
Skin Lesions ◽  
Puva Therapy ◽  
Level Of Evidence ◽  
European Organization ◽  
Significant Difference

Clinical reasoning. There is a need to optimize the use of UV-B-311 nm and PUVA-therapy in patients with mycosis fungoides to determine the duration of the treatment regimen, the number of sessions per week, and ultraviolet irradiation regimen. Goal of research. Evaluation of the effect of the type and duration phototherapy on efficacy in patients with mycosis fungoides. Principle. A comparative, non-randomized study of the effectiveness of phototherapy in patients with mycosis fungoides in the early stages. Evaluation of the effectiveness of UV-B-311 nm and PUVA therapy was performed using the BSA index (area of skin lesions) and Modified Severity-Weighted Assessment Tool (mSWAT), as well as according to the criteria proposed by the International Society for Skin Lymphomas (ISCL), the European Organization for the Study and Cancer Treatment (EORTC) and United States Cutaneous Lymphoma Consortium (USCLC). Results. The study included 14 patients with mycosis fungoides, 5 of whom received treatment with UV-B-311 nm, 9 PUVA therapy. A strong correlation was found between the duration of UV-B-311 nm therapy with mSWAT delta (R = 0.90; p = 0.038) and BSA delta (R = 0.90; p = 0.038), while similar correlation was not found in the PUVA-therapy group (mSWAT (R = 0.24; p = 0.527); BSA (R = 0.09; p = 0.823)). When comparing the effectiveness of therapy between the treatment group UV-B-311 nm and PUVA therapy, delta mSWAT and BSA at the 20th procedure, delta mSWAT and BSA after the end of therapy did not have a statistically significant difference between the UVB-311 nm and PUVA groups. Conclusion. Statistically significant correlation was found between the number of procedures and the effectiveness of therapy In the UV-B-311 nm group. An increase in the number of PUVA therapy procedures (after 20) does not lead to a statistically significant increase in the effectiveness of treatment. Additional research is needed to increase the level of evidence of the results and develop optimal phototherapy regimens.

scholarly journals PUVA Induced Bullous Pemphigoid in a Patient with Mycosis Fungoides

2017 ◽  
Vol 2017 ◽  
pp. 1-3 ◽  
Author(s):  
Birgül Özkesici ◽  
Saliha Koç ◽  
Ayşe Akman-Karakaş ◽  
Ertan Yılmaz ◽  
İbrahim Cumhur Başsorgun ◽  
...  
Keyword(s):  
Basement Membrane ◽  
Mycosis Fungoides ◽  
Bullous Pemphigoid ◽  
Normal Skin ◽  
The Elderly ◽  
Physical Factor ◽  
Direct Immunofluorescence ◽  
Puva Therapy ◽  
Inducing Factors ◽  
Upper Abdomen

Background. Bullous pemphigoid is an autoimmune subepidermal blistering skin disease in which autoantibodies are directed against components of the basement membrane. The disease primarily affects the elderly people and in most of the patients inducing factors cannot be identified. Herein, we report a case of BP that occurred in a patient who was receiving PUVA therapy for the treatment of mycosis fungoides. Main Observation. A 26-year-old woman with mycosis fungoides developed blisters while receiving PUVA therapy. On physical examination tense bullae on the normal skin, remnants of blisters, and erosions were observed on her breasts, the chest wall, and the upper abdomen. Histopathological investigations revealed subepidermal blisters with eosinophilic infiltration and in direct immunofluorescence examination linear deposition of IgG along the basement membrane zone was observed. The diagnosis of bullous pemphigoid was also confirmed by ELISA and BIOCHIP mosaic-based indirect immunofluorescence test. Conclusions. PUVA therapy is an extremely rare physical factor capable of inducing bullous pemphigoid. So the development of blistering lesions during PUVA therapy may be suggestive sign of a bullous disease such as bullous pemphigoid and it should be excluded with proper clinical and laboratory approaches immediately after withdrawal of PUVA therapy.

Bcl-2 expression in mycosis fungoides before and after PUVA therapy

2010 ◽  
Vol 26 (2) ◽  
pp. 107-109
Author(s):  
Hani Weshahy ◽  
Doa Mahgoub ◽  
Nermine El-Eishy ◽  
Amira Mohamed El-Tawdy ◽  
Dalia Ahmed Bassiouny ◽  
...  
Keyword(s):  
Mycosis Fungoides ◽  
Puva Therapy ◽  
Before And After

Long-term experience with low-dose interferon-alpha and PUVA in the management of early mycosis fungoides

2005 ◽  
Vol 75 (2) ◽  
pp. 136-145 ◽  
Author(s):  
Serena Rupoli ◽  
Gaia Goteri ◽  
Stefano Pulini ◽  
Alessandra Filosa ◽  
Angela Tassetti ◽  
...  
Keyword(s):  
Mycosis Fungoides ◽  
Interferon Alpha ◽  
Low Dose ◽  
Long Term Experience
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