scholarly journals Impact of Polypharmacy on Health-Related Quality of Life in Dialysis Patients

2021 ◽  
pp. 1-10
Author(s):  
Julia M.T. Colombijn ◽  
Anna A. Bonenkamp ◽  
Anita van Eck van der Sluijs ◽  
Joost A. Bijlsma ◽  
Arnold H. Boonstra ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Short Form ◽  
Health Related Quality ◽  
Dialysis Patients ◽  
Self Rated Health ◽  
Significant Difference ◽  
Related Quality ◽  
Health Related ◽  
The Mean

<b><i>Introduction:</i></b> Dialysis patients are often prescribed a large number of medications to improve metabolic control and manage coexisting comorbidities. However, some studies suggest that a large number of medications could also detrimentally affect patients’ health-related quality of life (HRQoL). Therefore, this study aims to provide insight in the association between the number of types of medications and HRQoL in dialysis patients. <b><i>Methods:</i></b> A multicentre cohort study was conducted among dialysis patients from Dutch dialysis centres 3 months after initiation of dialysis as part of the ongoing prospective DOMESTICO study. The number of types of medications, defined as the number of concomitantly prescribed types of drugs, was obtained from electronic patient records. Primary outcome was HRQoL measured with the Physical Component Summary (PCS) score and Mental Component Summary (MCS) score (range 0–100) of the Short Form 12. Secondary outcomes were number of symptoms (range 0–30) measured with the Dialysis Symptoms Index and self-rated health (range 0–100) measured with the EuroQol-5D-5L. Data were analysed using linear regression and adjusted for possible confounders, including comorbidity. Analyses for MCS and number of symptoms were performed after categorizing patients in tertiles according to their number of medications because assumptions of linearity were violated for these outcomes. <b><i>Results:</i></b> A total of 162 patients were included. Mean age of patients was 58 ± 17 years, 35% were female, and 80% underwent haemodialysis. The mean number of medications was 12.2 ± 4.5. Mean PCS and MCS were 36.6 ± 10.2 and 46.8 ± 10.0, respectively. The mean number of symptoms was 12.3 ± 6.9 and the mean self-rated health 60.1 ± 20.6. In adjusted analyses, PCS was 0.6 point lower for each additional medication (95% confidence interval [95% CI]: −0.9 to –0.2; <i>p</i> = 0.002). MCS was 4.9 point lower (95% CI: −8.8 to –1.0; <i>p</i> = 0.01) and 1.0 point lower (95% CI: −5.1–3.1; <i>p</i> = 0.63) for the highest and middle tertiles of medications, respectively, than for the lowest tertile. Patients in the highest tertile of medications reported 4.1 more symptoms than in the lowest tertile (95% CI: 1.5–6.6; <i>p</i> = 0.002), but no significant difference in the number of symptoms was observed between the middle and lowest tertiles. Self-rated health was 1.5 point lower for each medication (95% CI: −2.2 to –0.7; <i>p</i> &#x3c; 0.001). <b><i>Discussion/Conclusion:</i></b> After adjustment for comorbidity and other confounders, a higher number of medications were associated with a lower PCS, MCS, and self-rated health in dialysis patients and with more symptoms.

MO822POLYPHARMACY NEGATIVELY AFFECTS HEALTH-RELATED QUALITY OF LIFE IN DIALYSIS PATIENTS

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
Julia Colombijn ◽  
Anna Bonenkamp ◽  
Anita Van Eck van der Sluijs ◽  
Alferso C Abrahams ◽  
Joost Bijlsma ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Health Related Quality ◽  
Dialysis Patients ◽  
Self Rated Health ◽  
Therapeutic Benefits ◽  
Significant Difference ◽  
Related Quality ◽  
Health Related ◽  
The Mean

Abstract Background and Aims Dialysis patients are often prescribed a large number of medications to improve metabolic control and manage co-existing comorbidities. However, several studies suggest that a large number of medications can also detrimentally affect their health-related quality of life (HRQoL). Therefore, this study aims to provide insight in the association between the number of medications and various aspects of HRQoL in dialysis patients. Method A multicentre study was conducted among dialysis patients from Dutch dialysis centres three months after initiation of dialysis as part of the ongoing prospective DOMESTICO study. The number of medications, defined as the number of concomitantly prescribed types of drugs, was obtained from electronic patient records. Primary outcome was HRQoL measured with the Physical Component Summary (PCS) score and Mental Component Summary (MCS) score (range 0-100) of the Short Form 12. Secondary outcomes were number of symptoms (range 0-30) measured with the Dialysis Symptoms Index and self-rated health (range 0-100) measured with the visual analogue scale of the EuroQol-5D-5L. Data were analysed using linear regression and adjusted for possible confounders, including age, sex, dialysis modality, and comorbidity. Analyses for MCS and number of symptoms were performed after categorising patients in tertiles according to their number of medications because assumptions of linearity were violated for these outcomes. Results A total of 162 patients were included. Mean age of patients was 58 ± 17 years, 35% were female, and 80% underwent haemodialysis. The mean number of medications was 12.2 ± 4.5. Mean PCS and MCS were 36.6 ± 10.2 and 46.8 ± 10.0, respectively. The mean number of symptoms was 12.3 ± 6.9 and mean self-rated health 60.1 ± 20.6. In adjusted analyses, PCS was 0.6 point lower for each additional medication (95%CI -0.9 – -0.2; p=0.002). MCS was 4.9 point lower (95%CI -8.8 – -1.0; p=0.01) and 1.0 point lower (95%CI -5.1 – 3.1; p=0.63) for the highest and middle tertiles of medications, respectively, compared to the lowest tertile. Patients in the highest tertile of medications reported 4.1 more symptoms compared to the lowest tertile (95%CI 1.5 – 6.6; p=0.002) but no significant difference in the number of symptoms was observed between the middle and lowest tertile. Self-rated health was 1.5 point lower for each medication (95%CI -2.2 – -0.7; p&lt;0.001). Conclusion After adjustment for comorbidity and other confounders, a higher number of medications was associated with a lower PCS, MCS, and self-rated health in dialysis patients and with more symptoms. This suggests that it may be relevant to weigh expected therapeutic benefits of medication against their possible harmful effects on HRQoL. An unfavourable balance between expected benefits and impact on HRQoL might be ground to deviate from clinical guidelines, especially for patients with a limited life-expectancy and for whom a kidney transplant is unattainable.

scholarly journals Evaluation Of Oral Health-Related Quality Of Life In Children With Hematological Malignances

2021 ◽  
Author(s):  
Sevcihan Gunen Yilmaz ◽  
munevver kilic
Keyword(s):  
Quality Of Life ◽  
Oral Health ◽  
Hodgkin Lymphoma ◽  
Hematological Malignancies ◽  
Health Related Quality ◽  
Significant Difference ◽  
Related Quality ◽  
Health Related ◽  
The Mean

Objective: Chemotherapy and radiotherapy, used to treat childhood hematological malignancies (HM), can negatively impact oral tissues and organs. This study aimed to evaluate oral health-related quality of life in children with HM. Material and Methods: A total of 59 children, including 29 undergoing HM (21 for acute lymphocytic leukemia, 2 for acute myelocytic leukemia, 4 for Hodgkin lymphoma, and 2 for non-Hodgkin lymphoma) and 30 healthy volunteers, were included in this cross-sectional study. The mean age of the entire study group was 78.63 ± 34.41 months. The mean age of the HM and control groups was 87.12 ± 35.04 and 70.95 ± 34.85 months, respectively. The Simplified Oral Hygiene Index (SOHI), Decayed, Missing, and Filled Teeth (DMFT) index, and Turkish version of the Early Childhood Oral Health Impact Scale (ECOHIS-T) were administered to all children. The data were analyzed using SPSS software (version 22.0). Results: The age and gender distributions of the two groups were similar. The SOHI was significantly higher in the HM group, whereas the DMFT score was similar between the groups. No significant difference in the total ECOHIS-T score was observed between the two groups, but there was a group difference in the responses to questions on pain and psychological processes. Conclusions: Oral health and self-care were negatively affected by childhood HM and the treatment thereof. Close clinical dental follow-up of such patients is required. Keywords: Hematological malignancies, DMFT, Oral health-related quality of life

scholarly journals Impact of Oral Health-Related Quality of Life among Addicts' People in Ahvaz City; Iran

2021 ◽  
Author(s):  
Fatemh Saki ◽  
Hashem Mohamadian ◽  
Fataneh GhorbanyJavadpour ◽  
Maria Cheraghi
Keyword(s):  
Quality Of Life ◽  
Oral Health ◽  
Periodontal Diseases ◽  
Health Related Quality ◽  
Total Quality ◽  
Significant Difference ◽  
Related Quality ◽  
Health Related ◽  
The Mean

Abstract Backgrounds: Quality of life related to oral health impact profile-14 (OHIP-14) is one of the important dimensions of quality of life. Since using narcotics or stimulants increases the incidence of periodontal diseases, we aimed to determine impact of Oral health-related quality of life in narcotic or stimulant addicts who referred to maintenance methadone therapy (MMT) centers in Ahvaz City, Iran.Methods: It was descriptive-analytical cross-sectional study which has conducted on 187 narcotic and stimulant addicts who referred to MMT centers in Ahvaz city; 2020. The data collection tools included the demographic variables and the standard OHIP-14 questionnaires. Descriptive statistics, independent t-test, one-way analysis of variance, and LMS test were run at the significance level of less than 0.05. Results: The mean and standard deviation of the participants' age was 36.03 ± 8.98 years. The quality-of-life scores related to oral health were 34.89 ± 6.50 totally as well as 37.37 and 33.96 in narcotic and stimulant addicts, respectively. The total quality of life related to OHIP-14 did not have a significant relationship with variables of age, life companions, level of education, number of children, economic status, employment status, insurance status, underlying disease, toothbrush use status, last dentist visit, and number of missing teeth (P> 0.05). However, a significant difference was found between the quality of life related to oral health based on the type of substance used (narcotic or stimulant), so that the mean quality of life related to oral health was higher in narcotic addicts than stimulant users (P <0.05). Conclusion: The quality of life related to OHIP-14 was more unfavorable in stimulant users than narcotic users. So, policy makers and authorities are required to focus their interventions and research programs to improve health-related quality of life in addicts, especially stimulant users.

DETERMINANTS OF HEALTH STATUS AMONG PATIENTS WITH KNEE OR HIP OSTEOARTHRITIS: THE ROLE OF DEMOGRAPHIC, CLINICAL AND HEALTH RELATED QUALITY OF LIFE VARIABLES

2014 ◽  
Vol 17 (01) ◽  
pp. 1450004 ◽  
Author(s):  
Mohsen Saffari ◽  
Mohammad Kazem Emami Meybodi ◽  
Ghader Ghanizadeh ◽  
Harold G. Koenig
Keyword(s):  
Quality Of Life ◽  
Health Status ◽  
Short Form ◽  
Health Related Quality ◽  
Convenience Sample ◽  
Related Quality ◽  
Health Related ◽  
Duration Of Disease ◽  
The Mean

Osteoarthritis (OA) is a common chronic disease especially among older adults and has a considerable negative impact on health status (HS). This study investigated associations between demographic, clinical and health related quality of life (HRQOL) factors and the HS of patients with knee or hip OA. We surveyed a convenience sample of 356 patients from two general hospitals in Tehran, Iran. The short form health survey (SF-12), EuroQol (EQ-5D) and a demographic questionnaire were administered. Clinical variables such as body mass undex (BMI), duration of disease and radiographic evidence of the severity of OA were also collected. Two hierarchical regression models identified independent factors related to HS. The mean age of participants was 63.0 (SD, 12.3) and majority were female (90.7%). More than three-quarters were overweight or obese and over two-thirds had an OA severity grade of 3 or 4 based on Kellgren–Lawrence scale. The mean score on the physical and mental components of the SF-12 were 30.50 (SD, 9.63) and 44.38 (SD, 8.64), respectively. The mean scores for HS were 0.47 (SD, 0.34) on the EQ-5D and 63.23 (SD 17.58) on the EQ-VAS. Residence, duration of disease, BMI, OA joint, pain, vitality and mental health (MH) were identified as significant predictors of HS. Future studies are needed to better understand factors that may affect the HS of patients with knee or hip OA.

scholarly journals Hemodialysis patients perceived exercise benefits and barriers: the association with health-related quality of life

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Mansour Ghafourifard ◽  
Banafshe Mehrizade ◽  
Hadi Hassankhani ◽  
Mohammad Heidari
Keyword(s):  
Quality Of Life ◽  
Kidney Disease ◽  
Short Form ◽  
Pearson Correlation ◽  
Hemodialysis Patients ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related ◽  
The Mean

Abstract Background Patients on hemodialysis have less exercise capacity and lower health-related quality of life than healthy individuals without chronic kidney disease (CKD). One of the factors that may influence exercise behavior among these patients is their perception of exercise benefits and barriers. The present study aimed to assess the perception of hemodialysis patients about exercise benefits and barriers and its association with patients’ health-related quality of life. Methods In this cross-sectional study, 227 patients undergoing hemodialysis were randomly selected from two dialysis centers. Data collection was carried out using dialysis patient-perceived exercise benefits and barriers scale (DPEBBS) and kidney disease quality of life short form (KDQOL-SF). Data were analyzed using SPSS software ver. 21. Results The mean score of DPEBBS was 68.2 ± 7.4 (range: 24 to 96) and the mean KDQOL score was 48.9 ± 23.3 (range: 0 to 100). Data analysis by Pearson correlation coefficient showed a positive and significant relationship between the mean scores of DPEBBS and the total score of KDQOL (r = 0.55, p < 0.001). Moreover, there was a positive relationship between the mean scores of DPEBBS and the mean score of all domains of KDQOL. Conclusion Although most of the patients undergoing hemodialysis had a positive perception of the exercise, the majority of them do not engage in exercise; it could be contributed to the barriers of exercise such as tiredness, muscle fatigue, and fear of arteriovenous fistula injury. Providing exercise facilities, encouraging the patients by the health care provider to engage in exercise programs, and incorporation of exercise professionals into hemodialysis centers could help the patients to engage in regular exercise.

scholarly journals Association of income and health-related quality of life in atrial fibrillation

Open Heart ◽  
2019 ◽  
Vol 6 (1) ◽  
pp. e000974 ◽  
Author(s):  
Emily Guhl ◽  
Andrew Althouse ◽  
Michael Sharbaugh ◽  
Alexandra M Pusateri ◽  
Michael Paasche-Orlow ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Mental Health ◽  
Atrial Fibrillation ◽  
Daily Activity ◽  
Short Form ◽  
Health Related Quality ◽  
Significant Difference ◽  
Related Quality ◽  
Health Related

ObjectiveHealth-related quality of life (HRQoL) is a patient-centred benchmark promoted by clinical guidelines in atrial fibrillation (AF). Income is associated with health outcomes, but how income effects HRQoL in AF has limited investigation.MethodsWe enrolled a convenience cohort with AF receiving care at a regional healthcare system and assessed demographics, medical history, AF treatment, income, education and health literacy. We defined income as a categorical variable (<$20 000; $20 000–$49 999; $50 000–$99 999; >$100 000). We used two complementary HRQoL measures: (1) the atrial fibrillation effect on quality of life (AFEQT), measuring composite and domain scores (daily activity, symptoms, treatment concerns, treatment satisfaction; range 0–100); (2) the 12-item Short Form Survey (SF-12), measuring general HRQoL with physical and mental health domains (range 0–100). We related income to HRQoL and adjusted for relevant covariates.ResultsIn 295 individuals with AF (age 71±10, 40% women), we observed significant differences in HRQoL by income. Higher mean composite AFEQT scores were observed for higher income groups: participants with income <$20 000 had the lowest HRQoL (n=35, 68.2±21.4), and those with income >$100 000 had the highest HRQoL (n=64, 81.9±17.0; p=0.04). We also observed a significant difference by income in the AFEQT daily activity domain (p=0.02). Lower income was also associated with lower HRQoL in the mental health composite score of the SF-12 (59.7±21.5, income <$20 000 vs 79.3±16.3, income >$100 000; p<0.01).ConclusionWe determined that income was associated with HRQoL in a cohort with prevalent AF. Given the marked differences, we consider income as essential for understanding patient-centred outcomes in AF.

Musculoskeletal Symptoms in Hemodialysis Patients and their Effect on Health-Related Quality of Life

2020 ◽  
Vol 49 (3) ◽  
pp. 289-294
Author(s):  
Sara Ezzat ◽  
Samar Tharwat ◽  
Sherihan Abdelsalam ◽  
Ehab E. Eltoraby
Keyword(s):  
Quality Of Life ◽  
Negative Impact ◽  
Short Form ◽  
Musculoskeletal Symptoms ◽  
Health Related Quality ◽  
Related Quality ◽  
Important Health ◽  
Health Related ◽  
The Mean

Background/Aims: Hemodialysis (HD) represents one of the most commonly used modalities as a renal replacement therapy. Health-related quality of life (HRQoL) is much lower in HD patients than general population. Musculoskeletal (MSK) symptoms are one of the most important health problems that affect patients on maintenance HD. The main purpose of this study was to investigate the association between MSK symptoms and HRQoL among HD patients. Methods: The study was carried out on 200 patients with chronic renal failure on chronic HD at different nephrology units in Egypt. They completed the Arabic version of the Kidney Disease and Quality of Life-Short Form 1.3 Questionnaire and answered the questions of MSK discomfort form based on the Nordic MSK Questionnaire. Results: The mean age of the patients was 50.6 years, 61% were males. Of the 200 HD patients, 180 patients (90%) had MSK manifestations. The most commonly affected part was knee joint (51.5%). Regarding HRQoL, patients with MSK symptoms had significantly lower scores than did patients without on the physical role (p = 0.035), pain domain (p = 0.003), general health (p = 0.017), quality of social interaction (p = 0.046), and sleep domain (p = 0.022). Conclusion: MSK manifestations have a negative impact on HRQoL in HD patients. So, early identification and treatment are highly recommended.

scholarly journals HEALTH-RELATED QUALITY OF LIFE (HRQOL) IN OLDER ADULT SUBJECTS WITH KNEE OSTEOARTHRITIS PAIN

2021 ◽  
Vol 9 (5) ◽  
pp. 952-959
Author(s):  
Nimitha K.J ◽  
◽  
Bhupendra Singh ◽  
Radhey Shyam Gangwar ◽  
RN Srivastava ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Knee Osteoarthritis ◽  
Older Adult ◽  
Short Form ◽  
Health Related Quality ◽  
Osteoarthritis Pain ◽  
Significant Difference ◽  
Related Quality ◽  
Health Related

Aim of the study: The study aims to find the health-related quality of life (HRQoL) in older adult subjects with knee osteoarthritis pain. Material and methods: A cross-sectional, telephonic study was done on knee osteoarthritis subjects above 50 years of age. Socio-demographic scales and details,(ShalliBavoria, et al., 2020) i.e., WOMAC (Western Ontario and McMaster Universities Osteoarthritis Index), SF-12 (Short Form survey), PHQ-9 (Patient Health Questionnaire) et al were applied( Soo-Hyun Park and Byeong-Hun Kang., 2020). Information was retrospectively compiled and a semi-structured proforma was selected to gather the clinical variables. Results: Results were identified by domains of Health related quality of life.Results showed that there is significant difference in general health related quality of life based on the KL grading of KOA.(P=0.02,P=0.04)Study concluded that general HRQoL worsens with higher grading of KOA.The results showed that there was a substantial discrepancy witnessed between males and females where females encountered more pain.As stiffness increases HRQoL decreases. More severity of pain was observed in depressed people.(Roger B. Fillingim, et al., 2020) Conclusion: Daily challenges and actions, of which some may be unusual to sufferers in a pastoral setting in India, underlie sedentary and effective strategies to Osteoarthritis and its control. The study concluded that a significant difference in pain and general quality of life-based on the KL grading of KOA (P=0.02, P=0.04) was observed.(Hye-Young Shim, etal, 2018) It was also found that there is a considerable difference in pain based on the duration of ]knee osteoarthritis (P=0.05).( Aliasghar A. Kiadalir, et al., 2017).

scholarly journals Effect of a Worksite Walking Competition on Health-Related Quality of Life Among University Employees

2015 ◽  
Vol 12 (3) ◽  
Author(s):  
Breanna Orozco ◽  
Lisa Leininger ◽  
Kendra Contente
Keyword(s):  
Quality Of Life ◽  
Health Promotion ◽  
Short Form ◽  
Control Group ◽  
Health Related Quality ◽  
University Employees ◽  
Significant Difference ◽  
Related Quality ◽  
Health Related

Worksite health promotion programs (WHPPs) aim to improve the health and wellness of employees in an effort to improve health related quality of life (HRQOL). The effect of exercise on improving HRQOL is well documented among clinical populations. However, few studies have examined the effect of WHPPs on HRQOL. The purpose of this study was to investigate the effect of a six-week “Workplace Walk-Off Competition” (WWC) on HRQOL among university employees. One hundred and nine university employees were included in this study (WWC group: n=47, Control group: n=62). All study participants completed the Short Form 12 Question, Version 2 (SF-12v2), a HRQOL questionnaire, before and after the WWC. The SF-12v2 questionnaire determines HRQOL based on two components and reports scores for a physical component summary (PCS) score and a mental component summary (MCS) score. A two-way repeated measures ANOVA was performed on PCS and MCS scores, followed by dependent t-tests for each group. There was no significant difference in PCS or MCS scores between the groups. Further, there were no statistically significant changes in PCS or MCS scores (p>.05) among either group, following the six-week WWC. Although much research deems WHPPs effective for improving many health indicators, this short-term program was not effective in improving PCS and MCS components of HRQOL. KEYWORDS: Quality of Life, Health Promotion, Walking Competition, University Employees

Depressive symptoms and health-related quality of life in patients attending government – owned psychiatric clinics in Nigeria

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Deborah O. Aluh ◽  
Maxwell O. Adibe ◽  
Abubakar Abba ◽  
Chukwudi E. Sam-Eze ◽  
Abdulmuminu Isah
Keyword(s):  
Quality Of Life ◽  
Depressive Symptoms ◽  
Sociodemographic Characteristics ◽  
Health Related Quality ◽  
Content Type ◽  
Significant Difference ◽  
Related Quality ◽  
Health Related ◽  
The Mean

Purpose Depression and its symptoms negatively influence the health-related quality of life of patients. This paper aims to explore the occurrence of depressive symptoms and their relationship with health-related quality of life and sociodemographic characteristics. Design/methodology/approach It was a cross-sectional study conducted among patients attending the outpatient psychiatric clinics of two Nigerian hospitals. Data were collected using sociodemographic, PHQ-9 and 15 D questionnaires from a convenience sample of patients. Statistical Product and Services Solution Software (SPSS) version 21.0 was used to evaluate depressive symptoms, health-related quality of life, sociodemographic characteristics and the associations among them. Findings The mean depressive symptoms and health-related quality of life scores were found to be 12.118 ± 4.373 and 0.829 ± 0.141, respectively. The result showed a significant negative correlation (r = −0.318, p < 0.001) between respondents’ depressive symptoms and health-related quality of life. Patients with comorbid conditions reported a significantly higher level of depressive symptoms (p = 0.002) and lower health-related quality of life (p < 0.001). There was a significant difference in the mean health-related quality of life of the respondents across their level of education and marital status. Originality/value Depressive symptoms are a common occurrence in psychiatric conditions. This study provides an insight into the associations between depressive symptoms, socio-demographic factors and the health-related quality of life of psychiatric patients in a low-income country.

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