HPV Screening Test for the Detection of Precancerous Cervical Lesions and Cervical Cancer in Israeli Women

2021 ◽  
pp. 1-7
Author(s):  
Tali Feinberg ◽  
Einav Yehuda-Shnaidman ◽  
Tamar Wolf ◽  
Judith Sandbank ◽  
Jacob Segal ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Screening Test ◽  
The Other ◽  
Premalignant Lesions ◽  
First Year ◽  
Screening Methods ◽  
Age Group ◽  
Cervical Lesions ◽  
Precancerous Cervical Lesions ◽  
Cytology Screening

<b><i>Objectives:</i></b> This work is aimed to summarize the first year of the high-risk human papillomavirus (hrHPV) screening test and compare it to the cytology screening test, regarding positivity rates and premalignant lesions diagnosed in the Israeli population. A specific consideration is for the age group 25–30 that is not considered mandatory for the HPV primary screening testing. <b><i>Methods:</i></b> A retrospective study was performed in women who were screened for prevention of cervical cancer in Maccabi HealthCare HMO from March 2017 to March 2019. Screening methods included hrHPV typing for types 16, 18, and the other 12 hrHPV types and the PAP LBC test. <b><i>Results:</i></b> A total of 115,807 cervical samples were tested for HPV presence and 91% (105,225) were found negative for hrHPV. The other 9% (10,582) were positive for one or more of the 14 hrHPV types tested, and 37% (3,916) of them showed abnormal PAP LBC results. In the age group of 25–30, 3,104 (17.5%) women were found positive for hr­HPV (825 had hrHPV types 16 and/or 18), of which 42% (1,293) of them showed abnormal PAP LBC results. During the hrHPV versus PAP LBC screening era, 258 more women were diagnosed with precancerous cervical lesions (CIN2/3), 70% increased detection versus cytology screening. <b><i>Conclusions:</i></b> The hrHPV screening test is currently the best method for the detection of precancerous cervical lesions and cervical cancer, and it is better started at age 25.

Urine test for HPV genotypes as a predictor of precancerous cervical lesions and for cervical cancer screening

2018 ◽  
Vol 141 (3) ◽  
pp. 332-336 ◽  
Author(s):  
Ahmed M. Maged ◽  
Hany Saad ◽  
Emad Salah ◽  
Hadeer Meshaal ◽  
Mostafa AbdElbar ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Screening ◽  
Cervical Cancer Screening ◽  
Urine Test ◽  
Cervical Lesions ◽  
Hpv Genotypes ◽  
Precancerous Cervical Lesions

scholarly journals Determinants of precancerous cervical lesion among women screened for cervical cancer in south Ethiopia: A case-control study

2019 ◽  
Author(s):  
Tesfalidet Tekelab Beyene ◽  
Mohammed Akibu ◽  
Henok Bekele ◽  
Wengelawit Seyoum
Keyword(s):  
Cervical Cancer ◽  
Cancer Screening ◽  
Cervical Cancer Screening ◽  
Sexual Behaviour ◽  
Case Control Study ◽  
Case Control ◽  
Sexual Partners ◽  
Cervical Lesions ◽  
Precancerous Cervical Lesions ◽  
Control Study

Abstract Background Nearly 90% of deaths from cervical cancer occurred in low resource setting. In Ethiopia the magnitude of cervical cancer was 17%. Precancerous cervical lesions may progress to cervical cancer. Early screening and treatment of precancerous cervical lesions is a cost effective way to avert the growth of cervical cancer. However, there is a limited research on risk factors of precancerous cervical lesions in Ethiopia. Therefore the aim of this study was to identify determinants of precancerous cervical lesions in south Ethiopia.Method A facility based case-control study was carried out in five health facilities in south Ethiopia between 8 May to 28 September 2018. Interviewer administered questionnaires were used to collect data from 98 cases and 197 controls. Multivariate logistic regression was employed to identify determinants of precancerous cervical lesions.Results Women aged 30-39 years (AOR = 2.51, 95% CI: 1.03 – 6.08), monthly income < 42 USD and 43-66 USD (AOR = 3.41, 95% CI: 1.34 – 6.08; AOR = 3.63, 95% CI: 1.31 – 9.88), initiation of first sexual intercourse at age less than or equal to 20 (AOR = 2.39, 95% CI: 1.14 – 5.47), having more than one life time sexual partners (AOR=4.70, 95% CI:2.02–10.95), having a partner/ husband with more than one lifetime sexual partners (AOR=2.98, 95% CI: 1.35–6.65) had higher odds of precancerous cervical lesions.Conclusion Strategies to prevent precancerous cervical lesions should focus on modification of life style and sexual behaviour. The findings of this study highlight implications for policy makers by suggesting that targeting older women for cervical cancer screening, addressing inequalities and education relating to risky sexual behaviour may reduce precancerous cervical lesions. Further longitudinal study is needed to assess awareness of women about cervical cancer screening.

scholarly journals Role of Colposcopy in Detection of Dysplastic Cervical Lesion as a Screening Tool

2018 ◽  
Vol 4 (Supplement 2) ◽  
pp. 33s-33s
Author(s):  
P. Gyawali ◽  
S.R. KC ◽  
S. Ghimire
Keyword(s):  
Cervical Cancer ◽  
Cervical Carcinoma ◽  
Screening Tool ◽  
Cervical Lesion ◽  
Histopathological Diagnosis ◽  
Low Grade ◽  
High Grade ◽  
Age Group ◽  
Cervical Lesions ◽  
Papanicolaou Test

Background: Age standardized cervical cancer incidence rate in Nepal is 19.2/100,000 woman, compared with 14.0 worldwide. Similarly, mortality rate is 12.0 women which is significant in comparison with 6.8 worldwide. Cervical intraepithelial neoplasm is a precursor lesion, having high transformation rate into the cervical carcinoma. Data clearly indicates that CIN 2 and 3 has more progression into cervical carcinoma. Despite the fact that Papanicolaou test has remained an important tool in the screening for cervical cancer and has contributed in significant decrease in cervical cancer, sensitivity and specificity of conventional Papanicolaou test is quite low. Colposcopy is visual inspection of cervix under magnification. Study revealed that the positive predictive rate of the colposcopic impression is better as the cervical lesion is more severe. Aim: To find out the significance of colposcopy in the detection of dysplastic cervical lesions and possible use of this method as a screening tool. Methods: This is an observational study done at Cancer Care Foundation, Nepal done from a period of January 2015 to February 2018. Permission was obtained from ethical committee and written consent was obtained from the patients. All the patients suspected having dysplastic or invasive lesions or in whom colposcopy-guided biopsy was performed; were included in the study. Relevant data were collected which included age, colposcopic diagnosis, histopathological diagnosis. Data were entered into Microsoft Excel and statistical analysis was done from statistical package SPSS 21. Results: 6109 females were screened through colposcopy. Out of these 900 patients underwent colposcopy-guided biopsy for being suspected of dysplastic lesions or inflammatory lesions. Mean age of females was 40.65 years. With colposcopy, 407 (45.2%) were suspected to have low grade lesion, followed by 401 (44.6%) high grade lesion and 15 (1.7%) carcinoma. Nonneoplastic lesions were suspected in 77 (8.6%) females. In the histopathological examination low grade dysplasia was observed in 403 (44.8%) followed by 250 (27.8%) high grade dysplasia and 8 (0.9%) carcinoma in-situ or invasive carcinoma. Similarly, 239 (26.6%) patients had nonneoplastic lesions. In colposcopy, high grade lesions were suspected more frequently in females of 41-50 years age group than in 31-40 years age group ( P < 0.01). Correlation between increasing age and dysplastic lesions were also observed ( P < 0.05). There was significant correlation between colposcopic diagnosis and histopathological diagnosis with a P value < 0.01. The sensitivity of colposcopy to diagnose dysplastic lesions were high 96.44% with positive predictive value of 62.65%. The specificity of colposcopy to diagnose various grades of dysplastic lesions is 34.98%. Conclusion: Colposcopy is highly sensitive method of screening dysplastic cervical lesions and should be used more frequently as a screening purpose.

scholarly journals PAPILLOMAVIRAL CARCINOGENESIS. SIGNIFICANT ACHIEVEMENTS AND SPECIFIC CHALLENGES. PART 3. THREE LEVELS OF CERVICAL CANCER PREVENTION AND TREATMENT

2020 ◽  
Vol 19 (3) ◽  
pp. 6-11
Author(s):  
G. M. Volgareva
Keyword(s):  
Cervical Cancer ◽  
Cancer Prevention ◽  
Cervical Cancer Prevention ◽  
Cancer Diagnostics ◽  
Human Papillomaviruses ◽  
World Health ◽  
Cervical Lesions ◽  
Precancerous Cervical Lesions ◽  
Health Organization ◽  
And Control

Efficient prophylactic vaccines have been developed to prevent cervical cancer, a frequent female oncological disease caused by carcinogenic human papillomaviruses. World Health Organization worked out the program for prophylaxis of cervical cancer and control of the disease. It includes preventive adolescent vaccinations, screening of precancerous cervical lesions in women as well as cervical cancer treatment if originated. Cervical cancer diagnostics is being improved, development of therapeutic human papillomaviruses vaccines is in progress. The review deals with major achievements and certain challenges in the field of cervical cancer prevention.Part I see: Volgareva G.M. Papillomaviral carcinogenesis. Major achievements and certain challenges. Part I. General notions of papillomaviruses. Human papillomavirusesassociated cancers. Russian Journal of Biotherapy 2020;19(1):6–12.Part 2 see: Volgareva G.M. Papillomaviral carcinogenesis. Major achievements and certain challenges. Part 2. HPV-associated cancers in Russia. Preventive HPV vaccines. Russian Journal of Biotherapy 2020;19(2):31–8.

scholarly journals Magnitude and associated factors of VIA positive test results for cervical cancer screening among refugee women aged 25–49 years in North Ethiopia

BMC Cancer ◽  
2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Gebretsadik Hailemariam ◽  
Hailay Gebreyesus ◽  
Tewolde Wubayehu ◽  
Tsgehana Gebregyorgis ◽  
Kidanemariam Gebrecherkos ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Screening ◽  
Associated Factors ◽  
Previous History ◽  
Test Results ◽  
Cervical Lesions ◽  
Sexually Transmitted ◽  
Refugee Women ◽  
History Of ◽  
Precancerous Cervical Lesions

Abstract Background Worldwide cervical cancer is the third most common malignancy in women. It usually arises from the cervical area which is susceptible to Human Papilloma virus induced malignancy changes. In low-resource setting visual inspection with acetic acid (VIA) is an alternative sensitive cervical screening method. Therefore the aim of this study was to assess the magnitude and associated factors of VIA positive test results for Cervical Cancer screening among Eritrean refugee women aged 25–49 years in northern Ethiopia refugee camps. Methods A community based cross-sectional study was conducted among 412 Eritrean refugee women aged 25–49 years from august 10 to September 25, 2018. Study subjects were selected by simple random sampling method. Data were collected using pretested structured questioner through Face-to-face interview and cervical examination. Data were coded and entered to Epi info software version 7 and then exported to Statistical package for Social Science (SPSS) version 21 for analysis. Bivariable and multivariable logistic regression analysis was made to test the association between the independent variables and the outcome variable. P-value of less than 0.05 with 95% CI was considered to declare statistical significance. Result In this study the magnitude of VIA positive precancerous cervical lesions was 9% (95% CI: 6.3–11.8%). Previous history of sexually transmitted infections (STI) [AOR (95%CI) = 2.84(1.07–7.53)] and presence of STI during cervical examination [AOR (95%CI) =3.97(1.75–9.00)] were found significantly associated with VIA positive precancerous cervical lesions. Conclusions In this study the magnitude of VIA positive precancerous cervical lesions was high. Previous history of sexually transmitted infections (STI) and presence of STI during cervical examination were found associated with VIA positive precancerous cervical lesions. Efforts such as early screening for sexually transmitted disease shall be done to prevent precancerous cervical lesions.

Association between Toll-like Receptor and Tumor Necrosis Factor Immunological Pathways in Uterine Cervical Neoplasms

2016 ◽  
Vol 103 (1) ◽  
pp. 81-86 ◽  
Author(s):  
Lucas G.G. de Matos ◽  
Eduardo B. Cândido ◽  
Paula V.T. Vidigal ◽  
Polyanna H.C. Bordoni ◽  
Rivia M. Lamaita ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Tumor Necrosis ◽  
Critical Role ◽  
Immunological Response ◽  
Intraepithelial Neoplasia ◽  
Hpv Infection ◽  
Membrane Receptors ◽  
Premalignant Lesions ◽  
Cervical Lesions ◽  
Tnf Α

Introduction The immune system plays a critical role in the defense against human papillomavirus (HPV) infection and its persistence. Toll-like receptors (TLRs) are membrane receptors responsible for activation of the innate immune response, and an association between TLR expression and uterine cervical cancer has been shown. Tumor necrosis factors (TNFs) are among the main mediators of skin and mucosa inflammation. The aim of this study was to demonstrate the association between TLR and TNF immune expression and cervical cancer and premalignant cervical lesions. Methods A total of 64 embedded tissues were obtained from gynecological procedures, including 35 specimens with cervical intraepithelial neoplasia (CIN) and 10 specimens with cervical squamous cell carcinoma (CSCC) as well as 19 normal cervical samples. The expression of TLR2, TLR3, TLR4, TNF-α and TNF-β was measured by immunohistochemistry and graded into low and high levels of expression. Results There was an association between the expression levels of TLR2 and those of TNF-α and TNF-β (p = 0.01 and p = 0.021, respectively) in the cervical cancer and CIN groups. TLR4 expression was associated with TNF-α and TNF-β expression (p = 0.016 and p = 0.025, respectively) in these 2 groups. By contrast, TLR3 was not statistically associated with TNF-α or TNF-β in any of the groups. Conclusions There might be an association of the TLR2 and TLR4 pathways with the immunological response of TNF-α and TNF-β in cervical cancer. These markers are also expressed at higher levels in cervical cancer and premalignant lesions compared to normal controls.

scholarly journals Human Papilloma Virus L1 Gene Methylation as a Potential Biomarker for Precancerous Cervical Lesion: a Preliminary Report

2017 ◽  
pp. 120
Author(s):  
Suzanna P Mongan ◽  
Andrijono Andrijono ◽  
Hartono Tjahadi
Keyword(s):  
Cervical Cancer ◽  
Precancerous Lesions ◽  
Bisulfite Conversion ◽  
Cervical Lesions ◽  
Gene Methylation ◽  
Hpv 16 ◽  
Hpv Dna ◽  
Precancerous Cervical Lesions ◽  
Hpv 18 ◽  
Thin Band

Objective: To determine whether HPV L1 gene methylation can be used in triage of precancerous cervical lesions. The main objective is to determine the genotype of HPV in cervical precancerous lesions and to determine the percentage, the sensitivity, specificity, positive predictive value, negative predictive value, and likelihood ratio of DNA HPV L1 methylation in precancerous cervical lesions. Methods: A number of 57 samples of paraffin blocks (FFPE) from precancerous lesions and cervical cancer biopsies in the Department of Pathology Faculty of Medicine-Cipto Mangunkusumo General Hospital that had been re-evaluated by the pathologist, underwent extraction of HPV DNA. The genotypes of HPV DNA were examined using primers GP5 / 6 and specific HPV 16, HPV 18 and HPV 52 probes and analyzed by real time PCR. Sequencing was performed on samples with unknown HPV DNA type that were detected using the specific probes to determine the type of HPV. Bisulfite conversion procedure was then performed for the samples that met the inclusion criteria. Results: There were 30 samples (52.6%) with CIN 1, 12 samples (21.1%) CIN 2, 9 samples (15.8%) CIN 3 and 6 samples (10.5%) of cervical cancer. Most of the samples were 36-45 years (35.1%). Of the total 57 samples, 55 samples were successfully extracted and determined the DNA genotyping of HPV (96.5%). HPV 16 infections both in the form of single or multiple was found to be 76.36%. The samples were mostly dominated by co-infection of HPV16 and 18 (49.1%) followed by HPV 16 (24.6%) and HPV 18 (14.0%). Based on the sequencing results there were other types of high risk HPV infection found: HPV 33, HPV 35, HPV 58 and also undeterminate risk HPV 53 and low risk HPV 54. After several procedures of optimization for methylation examination of HPV DNA L1 there was thin band found in electrophoresis procedure in 8 of 42 samples (19%) of HPV 16 after bisulfite conversion but once it was purified there weren’t any band found so we can not proceed to the stage sequencing. Until now we are still in the stage of optimizing the methylation procedure. Conclusion: HPV 16 infection were most commonly found in the form of single or multiple. Co-infection of HPV 16 and 18 were found in the majority of the samples. There were no significant correlation between HPV type and the severity of cervical lesions. Until now, the examination of DNA methylation HPV L1 already obtained eight samples of HPV 16 with a thin band on electrophoresis but the result could not be concluded because it is still in the process of optimization. [Indones J Obstet Gynecol 2017; 5-2: 120-126] Keywords: HPV DNA genotype, L1 gene methylation, precancerous cervical lesions

scholarly journals HUBUNGAN ANTARA LESI PRAKANKER SERVIKS DENGAN SOSIODEMOGRAFI PEREMPUAN DI KECAMATAN LEGOK KABUPATEN TANGERANG TAHUN 2018

2020 ◽  
Vol 4 (1) ◽  
pp. 193 ◽  
Author(s):  
Destiyana Cika Claritha ◽  
Chandra Dewi ◽  
Shintia Christina
Keyword(s):  
Breast Cancer ◽  
Cervical Cancer ◽  
Analytical Study ◽  
Precancerous Lesions ◽  
Total Sample ◽  
Cervical Lesions ◽  
Cervical Intraepithelial Lesions ◽  
Cervical Precancerous Lesions ◽  
Precancerous Cervical Lesions ◽  
Intraepithelial Lesions

Cervical and breast cancer are the highest prevalence cancer in Indonesia in 2013 which caused death to Indonesian women, cervical cancer by 0.8‰ and breast cancer by 0.5‰. Precancerous lesions of the cervix also known as cervical intraepithelial lesions (Cervical Intraepithelial Neoplastic) are the beginning of changes to cervical carcinoma. In general, precancerous lesions of the cervix originate from the squamous columnar junction in the uterine cervix, which undergoes the process of metaplasia. This study aims to determine whether there is a relationship between precancerous cervical lesions and sociodemography of women in Kecamatan Legok Kabupaten Tangerang in 2018. This study uses an analytical study with cross sectionaI approach. The population is all women in Kecamatan Legok Kabupaten Tangerang who had sexual relations. Total sample are 47 people. Keywords: cervical cancer, cervical precancerous lesions, parity ABSTRAKPenyakit kanker serviks dan payudara merupakan penyakit kanker dengan prevalensi tertinggi di Indonesia pada tahun 2013 yang menyebabkan kematian pada perempuan Indonesia, yaitu kanker serviks sebesar 0,8‰ dan kanker payudara sebesar 0,5‰. Lesi prakanker pada serviks dikenal juga dengan sebutan lesi intraepitelial serviks (Cervical Intraephitelial Neoplasia) merupakan awal dari perubahan menuju karsinoma serviks. Pada umumnya lesi prakanker serviks ini berawal dari daerah squamocolumnar junction pada serviks uteri yang mengalami proses metaplasia. Penelitian ini bertujuan untuk mengetahui adakah hubungan antara lesi prakanker serviks dengn sosiodemografi perempuan di Kecamatan Legok Kabupaten Tangerang tahun 2018. Penelitian ini merupakan studi analitik dengan pendekatan cross sectionaI. Populasi penelitian adalah semua perempuan di Kecamatan Legok Kabupaten Tangerang yang sudah berhubungan seksual. Total sampel 47 orang.

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