Urine test for HPV genotypes as a predictor of precancerous cervical lesions and for cervical cancer screening

2018 ◽  
Vol 141 (3) ◽  
pp. 332-336 ◽  
Author(s):  
Ahmed M. Maged ◽  
Hany Saad ◽  
Emad Salah ◽  
Hadeer Meshaal ◽  
Mostafa AbdElbar ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Screening ◽  
Cervical Cancer Screening ◽  
Urine Test ◽  
Cervical Lesions ◽  
Hpv Genotypes ◽  
Precancerous Cervical Lesions

scholarly journals Determinants of precancerous cervical lesion among women screened for cervical cancer in south Ethiopia: A case-control study

2019 ◽  
Author(s):  
Tesfalidet Tekelab Beyene ◽  
Mohammed Akibu ◽  
Henok Bekele ◽  
Wengelawit Seyoum
Keyword(s):  
Cervical Cancer ◽  
Cancer Screening ◽  
Cervical Cancer Screening ◽  
Sexual Behaviour ◽  
Case Control Study ◽  
Case Control ◽  
Sexual Partners ◽  
Cervical Lesions ◽  
Precancerous Cervical Lesions ◽  
Control Study

Abstract Background Nearly 90% of deaths from cervical cancer occurred in low resource setting. In Ethiopia the magnitude of cervical cancer was 17%. Precancerous cervical lesions may progress to cervical cancer. Early screening and treatment of precancerous cervical lesions is a cost effective way to avert the growth of cervical cancer. However, there is a limited research on risk factors of precancerous cervical lesions in Ethiopia. Therefore the aim of this study was to identify determinants of precancerous cervical lesions in south Ethiopia.Method A facility based case-control study was carried out in five health facilities in south Ethiopia between 8 May to 28 September 2018. Interviewer administered questionnaires were used to collect data from 98 cases and 197 controls. Multivariate logistic regression was employed to identify determinants of precancerous cervical lesions.Results Women aged 30-39 years (AOR = 2.51, 95% CI: 1.03 – 6.08), monthly income < 42 USD and 43-66 USD (AOR = 3.41, 95% CI: 1.34 – 6.08; AOR = 3.63, 95% CI: 1.31 – 9.88), initiation of first sexual intercourse at age less than or equal to 20 (AOR = 2.39, 95% CI: 1.14 – 5.47), having more than one life time sexual partners (AOR=4.70, 95% CI:2.02–10.95), having a partner/ husband with more than one lifetime sexual partners (AOR=2.98, 95% CI: 1.35–6.65) had higher odds of precancerous cervical lesions.Conclusion Strategies to prevent precancerous cervical lesions should focus on modification of life style and sexual behaviour. The findings of this study highlight implications for policy makers by suggesting that targeting older women for cervical cancer screening, addressing inequalities and education relating to risky sexual behaviour may reduce precancerous cervical lesions. Further longitudinal study is needed to assess awareness of women about cervical cancer screening.

scholarly journals The burden of 14 hr-HPV genotypes in women attending routine cervical cancer screening in 20 states of Mexico: a cross-sectional study

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Abraham Campos-Romero ◽  
Karen S. Anderson ◽  
Adhemar Longatto-Filho ◽  
Marco A. Luna-Ruiz Esparza ◽  
David J. Morán-Portela ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Screening ◽  
Cervical Cancer Screening ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Hpv Genotypes

Can we substitute brush cytology for biopsy in the evaluation of cervical lesions under the guidance of colposcopy?

2005 ◽  
Vol 15 (3) ◽  
pp. 489-492
Author(s):  
Z. Eftekhar ◽  
N. Izadi-Mood ◽  
F. Yarandi ◽  
M. Khodamoradi ◽  
P. Rahimi-Moghaddam
Keyword(s):  
Cervical Cancer ◽  
Cancer Screening ◽  
Cervical Cancer Screening ◽  
Standard Method ◽  
Uterine Cervix ◽  
Gold Standard ◽  
Brush Cytology ◽  
Cervical Lesions ◽  
Gold Standard Method ◽  
Special Expertise

In cervical cancer screening, colposcopically directed biopsy is the gold standard method for identifying intraepithelial and occult invasive lesions of the uterine cervix. As biopsy needs special expertise and the procedure is not convenient for the patients, we sought to evaluate colposcopically directed brush cytology as a substitute for biopsy of cervical lesions. We studied a series of 150 women who were referred for colposcopic evaluation. Colposcopically directed brush cytology and biopsy were performed for all patients with abnormal colposcopic findings. A total of 40 samples were excluded due to unsatisfactory report of brush cytology. Of the remaining 110 samples, 34 abnormal pathologies were reported in biopsy evaluations, while only 9 abnormal cytologies were reported in brush cytology specimens. Brush cytology sensitivity and specificity were 26% and 97%, respectively. We conclude that colposcopically directed brush cytology is not a safe substitute for biopsy in the evaluation of cervical lesions.

scholarly journals Screen, Notify, See, and Treat: Initial Results of Cervical Cancer Screening and Treatment in Rwanda

2021 ◽  
pp. 632-638
Author(s):  
Marie-Aimee Muhimpundu ◽  
Fidele Ngabo ◽  
Felix Sayinzoga ◽  
Jean Paul Balinda ◽  
John Rusine ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Screening ◽  
Service Delivery ◽  
Cervical Cancer Screening ◽  
Health Workers ◽  
Screening Program ◽  
Public Awareness ◽  
Cervical Lesions ◽  
District Hospitals

PURPOSE To describe the first year results of Rwanda's Screen, Notify, See, and Treat cervical cancer screening program, including challenges encountered and revisions made to improve service delivery. METHODS Through public radio broadcasts, meetings of local leaders, church networks, and local women's groups, public awareness of cervical cancer screening opportunities was increased and community health workers were enlisted to recruit and inform eligible women of the locations and dates on which services would be available. Screening was performed using human papillomavirus (HPV) DNA testing technology, followed by visual inspection with acetic acid (VIA), and cryotherapy, biopsy, and surgical treatment for those who tested HPV-positive. These services were provided by five district hospitals and 15 health centers to HIV-negative women of age 35-45 and HIV-positive women of age 30-50. Service utilization data were collected from the program's initiation in September 2013 to October 2014. RESULTS Of 7,520 cervical samples tested, 874 (11.6%) screened HPV-positive, leading 780 (89%) patients to undergo VIA. Cervical lesions were found in 204 patients (26.2%) during VIA; of these, 151 were treated with cryoablation and 15 were referred for biopsies. Eight patients underwent complete hysterectomy to treat advanced cervical cancer. Challenges to service delivery included recruitment of eligible patients, patient loss to follow-up, maintaining HIV status confidentiality, and efficient use of consumable resources. CONCLUSION Providing cervical cancer screening services through public health facilities is a feasible and valuable component of comprehensive women's health care in resource-limited settings. Special caution is warranted in ensuring proper adherence to follow-up and maintaining patient confidentiality.

scholarly journals Cost analysis of different cervical cancer screening strategies in Mexico

2014 ◽  
Vol 56 (5) ◽  
pp. 492 ◽  
Author(s):  
Christyn M Beal ◽  
Jorge Salmerón ◽  
Yvonne N Flores ◽  
Leticia Torres ◽  
Víctor Granados-García ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Screening ◽  
Cervical Cancer Screening ◽  
Cost Effective ◽  
Poor Quality ◽  
Cervical Lesions ◽  
Hpv 16 ◽  
Papilloma Virus ◽  
Primary Screening ◽  
Screening Strategies

Objective. To compare the costs and number of unde- tected cases of four cervical cancer screening strategies (CCSS) in Mexico. Materials and methods. We estimated the costs and outcomes of the following CCSS: a) conventional Papanicolaou smear (Pap) alone; b) high-risk human papilloma virus testing (HR-HPV) as primary screening with Pap as reflex triage; c) HR-HPV as primary screening with HPV-16/18 typing, liquid-based cytology (LBC) and immunostaining for p16/Ki67 testing as reflex triage, and d) co-testing with HR-HPV and LBC with HPV-16/18 typing and immunostaining for p16/Ki67 as reflex triage. The outcome of interest was high-grade cervical lesions or cervical cancer. Results. HR-HPV testing, HPV typing, LBC testing and immunostaining is the best alternative because it is the least expensive option with an acceptable number of missed cases. Conclusions. The opportunity costs of a poor quality CCSS is many false negatives. Combining multiple tests may be a more cost-effective way to screen for cervical cancer in Mexico.

scholarly journals Magnitude and associated factors of VIA positive test results for cervical cancer screening among refugee women aged 25–49 years in North Ethiopia

BMC Cancer ◽  
2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Gebretsadik Hailemariam ◽  
Hailay Gebreyesus ◽  
Tewolde Wubayehu ◽  
Tsgehana Gebregyorgis ◽  
Kidanemariam Gebrecherkos ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Screening ◽  
Associated Factors ◽  
Previous History ◽  
Test Results ◽  
Cervical Lesions ◽  
Sexually Transmitted ◽  
Refugee Women ◽  
History Of ◽  
Precancerous Cervical Lesions

Abstract Background Worldwide cervical cancer is the third most common malignancy in women. It usually arises from the cervical area which is susceptible to Human Papilloma virus induced malignancy changes. In low-resource setting visual inspection with acetic acid (VIA) is an alternative sensitive cervical screening method. Therefore the aim of this study was to assess the magnitude and associated factors of VIA positive test results for Cervical Cancer screening among Eritrean refugee women aged 25–49 years in northern Ethiopia refugee camps. Methods A community based cross-sectional study was conducted among 412 Eritrean refugee women aged 25–49 years from august 10 to September 25, 2018. Study subjects were selected by simple random sampling method. Data were collected using pretested structured questioner through Face-to-face interview and cervical examination. Data were coded and entered to Epi info software version 7 and then exported to Statistical package for Social Science (SPSS) version 21 for analysis. Bivariable and multivariable logistic regression analysis was made to test the association between the independent variables and the outcome variable. P-value of less than 0.05 with 95% CI was considered to declare statistical significance. Result In this study the magnitude of VIA positive precancerous cervical lesions was 9% (95% CI: 6.3–11.8%). Previous history of sexually transmitted infections (STI) [AOR (95%CI) = 2.84(1.07–7.53)] and presence of STI during cervical examination [AOR (95%CI) =3.97(1.75–9.00)] were found significantly associated with VIA positive precancerous cervical lesions. Conclusions In this study the magnitude of VIA positive precancerous cervical lesions was high. Previous history of sexually transmitted infections (STI) and presence of STI during cervical examination were found associated with VIA positive precancerous cervical lesions. Efforts such as early screening for sexually transmitted disease shall be done to prevent precancerous cervical lesions.

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