Atemwegsallergien: Schimmelpilz-Sensibilisierungen bei Asthma-Patienten in Betracht ziehen

2021 ◽  
pp. 1-2
Author(s):  
Marcus Joest

<b>Background:</b> Fungal spores are ubiquitous allergens. Severe forms of asthma are particularly highly associated with fungal sensitization. National and international asthma guidelines recommend the implementation of allergen immunotherapy if indicated. Thus, detection and treatment of relevant allergies are key components of primary care of these patients. <b>Objectives:</b> The aims of the study were (i) to investigate trends in the prevalence of sensitization to twelve fungi in central Germany over the last 20 years and (ii) to dissect specific sensitization patterns among the 3 most important fungi: <i>Aspergillus</i>, <i>Alternaria</i>, and <i>Cladosporium</i>. <b>Methods:</b> This single-center study evaluated skin prick test (SPT) results of 3,358 patients with suspected airway allergies over a period of 20 years (1998–2017). <b>Results:</b> While 19.2% of all study patients had positive test results to at least 1 of the 3 fungi (<i>Alternaria</i>, <i>Aspergillus</i>, or <i>Cladosporium</i>) in the first study decade, this rate increased to 22.5% in the second decade. Slight increases in sensitization rates to almost all fungi were observed over the 20-year period. In the last decade, polysensitization to <i>Alternaria</i>, <i>Aspergillus</i>, and <i>Cladosporium</i>increased significantly. Sensitization to fungi is age-dependent and peaks in the age-group of 21–40 years during the second decade. <b>Conclusion:</b> Fungi are relevant allergens for perennial and seasonal allergy symptoms. We currently recommend including <i>Aspergillus</i>, <i>Alternaria</i>, and <i>Cladosporium</i>in the standard series of SPTs for airway allergies.

Author(s):  
Susann Forkel ◽  
Caroline Beutner ◽  
Silke S. Schröder ◽  
Oliver Bader ◽  
Sidhi Gupta ◽  
...  

<b><i>Background:</i></b> Fungal spores are ubiquitous allergens. Severe forms of asthma are particularly highly associated with fungal sensitization. National and international asthma guidelines recommend the implementation of allergen immunotherapy if indicated. Thus, detection and treatment of relevant allergies are key components of primary care of these patients. <b><i>Objectives:</i></b> The aims of the study were (i) to investigate trends in the prevalence of sensitization to twelve fungi in central Germany over the last 20 years and (ii) to dissect specific sensitization patterns among the 3 most important fungi: <i>Aspergillus</i>, <i>Alternaria</i>, and <i>Cladosporium</i>. <b><i>Methods:</i></b> This single-center study evaluated skin prick test (SPT) results of 3,358 patients with suspected airway allergies over a period of 20 years (1998–2017). <b><i>Results:</i></b> While 19.2% of all study patients had positive test results to at least 1 of the 3 fungi (<i>Alternaria</i>, <i>Aspergillus</i>, or <i>Cladosporium</i>) in the first study decade, this rate increased to 22.5% in the second decade. Slight increases in sensitization rates to almost all fungi were observed over the 20-year period. In the last decade, polysensitization to <i>Alternaria</i>, <i>Aspergillus</i>, and <i>Cladosporium</i> increased significantly. Sensitization to fungi is age-dependent and peaks in the age-group of 21–40 years during the second decade. <b><i>Conclusion:</i></b> Fungi are relevant allergens for perennial and seasonal allergy symptoms. We currently recommend including <i>Aspergillus</i>, <i>Alternaria</i>, and <i>Cladosporium</i> in the standard series of SPTs for airway allergies.


Vaccines ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 152
Author(s):  
Beatrice Zanella ◽  
Angela Bechini ◽  
Benedetta Bonito ◽  
Marco Del Riccio ◽  
Alessandra Ninci ◽  
...  

Background: Varicella is a well-known infectious disease that can have severe complications, also in young children. The Universal Varicella Vaccination (UVV) program was introduced in Tuscany (Italy) in 2003, with a two-dose vaccine schedule given to children between their 13th and 15th month, and at 5–6 years old, as a monovalent for varicella (V) or tetravalent (measles, mumps, rubella and varicella (MMRV)) formulation. Although varicella notifications have dramatically fallen in the last two decades, varicella disease underreporting remains a challenge. Methods: A qualitative immunoenzymatic test (ELISA) was used to measure the presence of anti-varicella antibodies in 165 sera of subjects aged 1–18 years residing in the province of Florence (Italy). Information regarding the anamnestic and vaccination status (including disease notification) was also collected. Results: Our study showed an overall varicella seropositivity of 75.8% (reaching the maximum at 96.3% in the 15–18 years age group). We found that varicella disease notification had been recorded for only 7/165 subjects; however, since 42/165 recalled having had the disease, we can hypothesize that some of them must have been underreported. Furthermore, our study showed that the presence of antibodies after the varicella vaccination remained over time, lasting up to 12 years. Conclusions: Although varicella seroprevalence is <95% in almost all our age groups (except for the 15–18 years age group), our data are encouraging and reflect the success of the introduction of the UVV program and the vaccination campaigns promoted in the Tuscany region.


Author(s):  
Emine Colgecen ◽  
Kemal Özyurt ◽  
Yavuz Selim İntepe ◽  
Zeliha Kapusuz Gencer ◽  
Mahmut Özkırış ◽  
...  

1982 ◽  
Vol 14 (1) ◽  
pp. 7-16 ◽  
Author(s):  
M. A. Khalifa

SummaryIn a survey of 1475 urban Moslem wives in the age group 15–49 living in the capital city of the Sudan, knowledge of birth control was reported by almost all respondents while a significant proportion had used contraception at least once. The mean age of the users was 32·8 years, their duration of marriage was 15·1 years and their mean number of surviving children was 4·6. Those who had never used contraception had a higher mean age, a longer duration of marriage and more surviving children. Most of the users had an urban residential background and belonged to the high socioeconomic class. They held favourable attitudes to family planning. Although they thought that having a large family (more than five children) was not desirable, their mean preferred family size was no different from that of the never users.The results indicate that contraception is used for the purpose of spacing births rather than limiting their ultimate number. At this early stage of contraceptive adoption in Sudan, the characteristics of the pioneer acceptors are similar to those observed in other African countries.


1981 ◽  
Author(s):  
Deborah W. Berman

This study develops a simplified comparative procedure for use in preliminary yacht design to predict Equilibrium sideforce, resistance, leeway angle and speed made good to windward for a canoe hull sailing yacht within specific form parameters on any of five standard series keels. These forces, angles and speeds are predicted for any yacht hull resembling one of nine models - ranging from light to medium-heavy length to displacement ratio - (190 to 351) - of the Delft Systematic Series for which there is numerical data. The forces are calculated at speed to length ratio of 1. 3 and heel angle of 30° to enable the designer to make use of existing comparative sail plan and rigging data. The five keels of varying aspect and area ratio, spanning current design practice, are part of a matrix developed at the Davidson Laboratory. In this paper, a canoe yacht hull form similar to Model 7 of the Delft Series is tank tested on 3 Standard Series keels and compared to results obtained from testing a 5.5 m hull, which is similar to Model 8, on the same keels. A prediction procedure is developed and checked against test results. A few Equations, selected values from included tabulations, a calculator, pencil and paper will yield quantitative information for the yacht designer in the selection of a keel for the hull of a sailing yacht.


2007 ◽  
Vol 35 (1) ◽  
pp. 21-24 ◽  
Author(s):  
E. Dibek Misirlioğlu ◽  
M. Reha Cengizlier

2020 ◽  
pp. 1-4
Author(s):  
Sonal Khade Ahuja ◽  
Ashish Deshmukh ◽  
Sanmitra Aiholli ◽  
Omkar Kulkarni

Background: Periorbital hypermelanosis also called dark circles form the major percentage of dermatology consultations. Importance of these disorders is growing as they cause easy visible cosmetic disfigurement and significant psychosocial consequences. Aims: To assess the patients of POH disorders for demographic, etiological and clinical profile. Methods: This prospective hospital-based clinical study, conducted in a tertiary medical center over a period of two years, involved 200 patients with POH disorders, assessed using detailed history taking and clinical examination for demographic, etiological and clinical data. Data is statistically described in frequencies (number of cases) and percentages(%) . Results: Majority of patients were in age group 18-40 years. Females dominated the study with a number of 169 (84.5%) , only 31 (15.5%) were males. Most of the patients belonged to Grade 2 (53%), grade 3 was seen in 27% patients followed by grade 1 (16.5% ) and grade 4 (3.5% ) POH. Family history was positive in 81.5% patients. POH was observed mostly in housewives 93 (46.5%) and patients with indoor occupation 69 (34.5%) and less commonly in patients with outdoor occupation 29 (14.5%). Almost all cases of POH gave history of exacerbation following sun exposure. Not a single patient showed hepatic, renal complaints, hypothyroidism or ecchymosis. Majority of patients (86.5%) had altered Sleeping habits. Alcohol and smoking did not have a significant co-relation with POH. It was found that only five percent females on oral contraceptives developed POH and there was no change in Pigmentation of POH in relation to menstrual cycle in any of the females. Limitations: The quantitative assessment of melanin by specialized instrument ( mexameter) could not be done because of lack of resources.


Author(s):  
J. P. M. van der Valk ◽  
R. Gerth van Wijk ◽  
E. Hoorn ◽  
L. Groenendijk ◽  
I. M. Groenendijk ◽  
...  

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