scholarly journals Plasma Xanthine Oxidoreductase Activity Associated with Glycemic Control in Patients with Pre-Dialysis Chronic Kidney Disease

2021 ◽  
pp. 1-9
Author(s):  
Shinya Nakatani ◽  
Eiji Ishimura ◽  
Takayo Murase ◽  
Takashi Nakamura ◽  
Ayumi Nakatani ◽  
...  
Keyword(s):  
Uric Acid ◽  
Glycemic Control ◽  
Multiple Regression ◽  
Plasma Glucose ◽  
Hemoglobin A1c ◽  
Cross Sectional Study ◽  
Xanthine Oxidoreductase ◽  
Oxidoreductase Activity ◽  
Cross Sectional ◽  
Increased Risk

<b><i>Introduction:</i></b> Xanthine oxidoreductase (XOR) activity plays an important role as a pivotal source of reactive oxygen species, which is associated with cardiovascular disease (CVD) events. Patients with CKD have increased risk of CVD events. In the present study, factors associated with plasma XOR activity in pre-dialysis CKD patients were investigated. <b><i>Methods:</i></b> In this cross-sectional study, plasma XOR activity in 118 pre-dialysis CKD patients (age 68 [57–75] years; 64 males, 26 with diabetes mellitus [DM]) was determined using a newly established highly sensitive assay based on (<sup>13</sup>C<sub>2</sub>,<sup>15</sup>N<sub>2</sub>) xanthine and liquid chromatography/triple quadrupole mass spectrometry. <b><i>Results:</i></b> Plasma glucose, hemoglobin A1c, and estimated glomerular filtration (eGFR) were significantly and positively correlated with plasma logarithmically transformed XOR (ln-XOR) activity. In multiple regression analyses, eGFR and hemoglobin A1c or plasma glucose were significantly, independently, and positively associated with plasma ln-XOR activity after adjusting for several confounders. Plasma XOR activity was significantly higher in CKD patients with (<i>n</i> = 26) than in those without (<i>n</i> = 92) DM (62.7 [32.3–122] vs. 25.7 [13.4–45.8] pmol/h/mL, <i>p</i> &#x3c; 0.001). A total of 38 patients were taking uric acid-lowering drugs. Multiple regression analysis of CKD patients not administered uric acid-lowering drugs (<i>n</i> = 80) showed no significant association between eGFR and plasma ln-XOR activity. In contrast, association between glycemic control and plasma ln-XOR activity was significant even in CKD patients without uric acid-lowering drug treatment. <b><i>Conclusions:</i></b> These results indicate the importance of glycemic control in CKD patients in regard to decreased XOR, possibly leading to a decrease in CVD events.

Association Between Serum Uric Acid and Prediabetes in the Korean General Population

2019 ◽  
Vol 31 (8) ◽  
pp. 719-727
Author(s):  
Ryoung Jin Park ◽  
Min Gu Kang
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Hemoglobin A1c ◽  
Multiple Logistic Regression Analysis ◽  
Fasting Blood Glucose ◽  
Density Lipoprotein ◽  
Cross Sectional Study ◽  
Activity Level ◽  
Cross Sectional ◽  
Increased Risk

The purpose of this study is to examine the relation of serum uric acid with prediabetes in Korea. We conducted a cross-sectional study in 4633 individuals aged 20 to 81 years who participated in the 2016 Korean National Health and Nutrition Examination Survey. Participants are considered to have prediabetes if they have one or more of the following: impaired fasting glucose (fasting blood glucose levels between 5.6 and 6.9 mmol/L); impaired hemoglobin A1c (hemoglobin A1c ranges of 5.7% to 6.4% [39-46 mmol/mol]). Multiple logistic regression analysis was used to compute odds ratios (ORs) and 95% confidence intervals (CIs). Prediabetes was more prevalent in the hyperuricemia group compared with the normal-range group among men (OR = 1.51; 95% CI = 1.11-2.05; P < .01) and women (OR = 1.84; 95% CI = 1.01-3.37; P = .04) after adjustment for age, body mass index, abdominal obesity, blood pressure, triglyceride, high-density lipoprotein cholesterol, renal function, alcohol consumption, smoking, and physical activity level. For a standard deviation increment in uric acid, the odds of having prediabetes as compared with that of not having prediabetes increased about 114% in men ( P = .05) and 116% in women ( P = .01). Higher levels of uric acid were associated with an increased risk of prediabetes among the general Korean population.

scholarly journals Xanthine oxidoreductase activity is associated with serum uric acid and glycemic control in hemodialysis patients

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Ayumi Nakatani ◽  
Shinya Nakatani ◽  
Eiji Ishimura ◽  
Takayo Murase ◽  
Takashi Nakamura ◽  
...  
Keyword(s):  
Uric Acid ◽  
Glycemic Control ◽  
Serum Uric Acid ◽  
Hemodialysis Patients ◽  
Xanthine Oxidoreductase ◽  
Oxidoreductase Activity

scholarly journals The Association Between Uric Acid and Symmetric Dimethylarginine Levels in the Patients Undergoing Twice-weekly Hemodialysis

2021 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Aida Lydia ◽  
Yassir Yassir ◽  
Rudy Hidayat ◽  
Suhendro Suwarto
Keyword(s):  
Uric Acid ◽  
Venous Blood ◽  
Tertiary Hospital ◽  
Cross Sectional Study ◽  
Hemodialysis Patients ◽  
Bivariate Analysis ◽  
Symmetric Dimethylarginine ◽  
Cross Sectional ◽  
Increased Risk ◽  
History Of

Background: Uric acid (UA) levels are associated with increased risk of cardiovascular events and mortality in hemodialysis patients. However, there are still conflicting data on the mechanism of increased risks related to uric acid levels. Objectives: This study assessed the association between uric acid levels and symmetric dimethylarginine (SDMA), as a marker of cardiovascular disease, in the subjects undergoing hemodialysis twice weekly. Methods: This was a cross-sectional study conducted in a tertiary hospital in Jakarta, Indonesia. We included all the adults who underwent hemodialysis twice weekly for at least three months in our hospital. Subjects already on uric acid lowering therapy, pregnant or lactating women and those with a history of malignancy were excluded. Uric acid and SDMA levels were measured at the same time in pre-dialysis venous blood samples. Bivariate analysis was performed using the Mann-Whitney U test or one-way ANOVA. Results: A total of 126 subjects were included. The median level of UA was 8.4 mg/dL (IQR: 2.6, min: 4.1, max: 13.6), and 72 subjects (57.14%) had UA levels of 8 mg/dL or higher. The median SDMA level was 535.5 (312.7) mmol/dL (min: 119.7, max: 1895.5). Subjects with UA levels > 8 mg/dL had significantly higher SDMA levels compared to subjects with UA levels < 8 mg/dL (550.1 (IQR: 357.25) vs 491.35 (IQR: 181.1), P: 0.0475). Conclusions: In twice-weekly hemodialysis patients, UA levels above 8 mg/dL were associated with increased SDMA levels.

scholarly journals Identifying the Risk Factors and the Prevalence of Poor Glycemic Control among Diabetic Outpatients in a Rural Region in Saudi Arabia

2021 ◽  
pp. 15-23
Author(s):  
Ziyad S. Almalki ◽  
Nehad Jaser Ahmed ◽  
Abdullah K. Alahmari ◽  
Ahmed M. Alshehri ◽  
Sheikah Abdullah Alyahya ◽  
...  
Keyword(s):  
Risk Factors ◽  
Saudi Arabia ◽  
Glycemic Control ◽  
Cross Sectional Study ◽  
Poor Glycemic Control ◽  
Diabetic Patients ◽  
Cross Sectional ◽  
Rural Region ◽  
Increased Risk ◽  
Hba1c Levels

Aim: This cross-sectional study aimed to assess the prevalence of poor glycemic control and risk factors associated with it among diabetic patients in the central rural region of Saudi Arabia. Methods: The study included a review of diabetic patients’ medical record in King Khaled Hospital in Al-Kharj from the beginning of January 2019 to the end of June 2019. Poor glycemic control was defined as the current use of diabetic-lowering medication associated with HbA1c levels ≥7%. Multivariate analysis was done to identify the associated factors of poor glycemic control. Results: Of 1,010 consecutive outpatients’ diabetic patients were involved in the study sample, poor glycemic control presented in 496 (49.1%). Individuals who were at risk to have poor glycemic control those between 45 and 65 years with odds ratio (OR) of 1.927 (95% CI: 1.143–3.248), obese 1.496 (95% CI: 1.085–2.063) and diagnosed with asthma 2.062 (95% CI: 1.637–3.504). Conclusion: The extent of poor glycemic control in the study sample was found high. Age, obesity, and having asthma are the most important factors of increased risk of poor glycemic control. Improving glycemic control would need rigorous efforts by addressing these factors.

Pyrazinamide Induced Hyperuricemia in the Induction Phase of Anti-Tuberculosis Therapy

2021 ◽  
Vol 15 (5) ◽  
pp. 1136-1138
Author(s):  
N. Muhammad ◽  
S. Mehboob ◽  
M. Abbas
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Cross Sectional Study ◽  
Health Concern ◽  
Induction Phase ◽  
Global Public Health ◽  
Metabolic Disturbances ◽  
Cross Sectional ◽  
Intensive Phase ◽  
Increased Risk

Background: Tuberculosis (TB) is a global public health concern; although there are several recognized anti-tuberculosis drugs (ATDs) that effectively combat Mycobacterium tuberculosis (MTB), the associated adverse effects lead to frequent discontinuation. Objective: To assess the metabolic disturbances resulting from Pyrazinamide, the altered serum uric acid (SUA) levels among TB patients in District Bunir. Study Design: Cross-sectional study Place and Duration of Study: Department of Medicine, Bilal Medical Trust Hospital, Bunir-KPK from 1st January to 30th September 2019. Methodology: One hundred and nine tuberculosis patients were included in the study. All these patients were on ATD with Pyrazinamide and were regularly followed up, and their SUA levels were determined at weeks 0, 4 and 8. Results: The serum uric acid levels were high in almost 85.3% in the intensive phase of anit-TB Therapy (ATT). Among female TB patients, the incidence rate of hyperuricemia was comparatively higher than males (88.1% vs. 81.0%), but there were no significant gender disparities. Conclusion: The anti-tuberculosis drug with pyrazinamide is associated with an increased risk of hyperuricemia. Therefore, the illness needs to be closely monitored during the intensive phase of therapy. Key words: Pyrazinamide, Tuberculosis, Hyperuricaemia

scholarly journals Prevalence and associated factors of hyperuricemia among urban adults aged 35–79 years in southwestern China: a community-based cross-sectional study

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Xiao-Bo Huang ◽  
Wen-Qiang Zhang ◽  
Wei-Wei Tang ◽  
Ya Liu ◽  
Yuan Ning ◽  
...  
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Large Scale ◽  
Cross Sectional Study ◽  
Southwestern China ◽  
Current Cigarette Smoking ◽  
Cross Sectional ◽  
Major Health Problem ◽  
Increased Risk ◽  
Urban Adults

Abstract Hyperuricemia is prevalent throughout the world. However, a well-designed large-scale epidemiological investigation of hyperuricemia in southwestern China is lacking. A regional representative sample of 10,141 participants were included using multistage, stratified sampling in Chengdu and Chongqing from September 2013 to March 2014. Hyperuricemia was defined as the self-reported of the doctor's diagnosis of hyperuricemia, or serum uric acid > 420 μmol/L in men or serum uric acid > 360 μmol/L in women. The overall age- and sex-standardized prevalence of hyperuricemia among adults aged 35–79 years was 13.5%. Compared with women, the prevalence of hyperuricemia in men was higher (17.3% versus 10.0%). Hypertension, hyperlipidemia, overweight or obesity, central obesity were associated with an increased risk for hyperuricemia both in men and in women. Married men and women were not susceptible to hyperuricemia. Current cigarette smoking was an associated risk factor of hyperuricemia only in women. Hyperuricemia has become a major health problem among urban adults aged 35–79 years in southwestern China, and special attention should be paid to men. Comorbidities associated with hyperuricemia and causality worth further investigation.

scholarly journals Glycemic Control during Pregnancy—A Predictor of Vitamin C Status at Labor in Type 1 Diabetic Women?

Antioxidants ◽  
2019 ◽  
Vol 8 (6) ◽  
pp. 153
Author(s):  
Bente Juhl ◽  
Finn F. Lauszus ◽  
Jens Lykkesfeldt
Keyword(s):  
Glycemic Control ◽  
Vitamin C ◽  
Experimental Studies ◽  
Late Pregnancy ◽  
First Trimester ◽  
Cross Sectional Study ◽  
Third Trimester ◽  
Cross Sectional ◽  
Increased Risk

Several experimental studies have suggested that vitamin C (vitC) deficiency during pregnancy may be detrimental to fetal development, and observational studies have shown that vitC status is lower during pregnancy and in people with diabetes. A cross-sectional study in pregnant type 1 diabetic women found that poor maternal vitC status was a significant predictor for obstetric complications of pregnancy when measured within four weeks before labor. The plasma vitC concentration was significantly negatively correlated to HbA1c, the biomarker of glycemic control well-known to be associated with the outcome of the diabetic pregnancy. Here, we evaluated HbA1c during pregnancy in relation to the measured vitC levels in late pregnancy based on data from 46 women from the same cohort. Regression analysis showed that HbA1c of first trimester, the combined mean HbA1c of first and second trimester, mean HbA1c of the whole pregnancy (first, second and third trimester combined), and HbA1c of third trimester alone were all associated with vitC in late pregnancy (p = 0.03, n = 45; p = 0.034, n = 43; p = 0.017, n = 42; and p = 0.008, n = 46, respectively). In third trimester, when adjusted for creatinine clearance, the association between vitC and HbA1c persisted (p = 0.029). Women in third trimester with HbA1c above 7.0% had an increased risk of having poor vitC status compared to women with HbA1c below this level (11 out of 21 vs. 2 out of 25 women, p < 0.001). The results suggest that high HbA1c is associated with poor maternal vitC status and potentially inadequate supply of vitC for the neonate. HbA1c may thus be a relevant substitute biomarker for identifying pregnant women who might benefit from vitC supplementation.

scholarly journals High serum uric acid concentration is a risk factor for radiographic spondyloarthritis: a cross-sectional study

2020 ◽  
Author(s):  
Yupeng Lai ◽  
Yanpeng Zhang ◽  
Zhihao Lei ◽  
Yihong Huang ◽  
Tongxin Ni ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Uric Acid ◽  
Risk Factor ◽  
Multiple Imputation ◽  
Serum Uric Acid ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Increased Risk ◽  
Serum Uric Acid Concentration

Abstract Background: Cardiovascular disease is a kind of comorbidity of spondyloarthritis (SpA). Hyperuricaemia is a risk factor of cardiovascular disease. Previous SpA study concerning cardiovascular disease and hyperuricaemia found that hyperuricaemia is more prevalent in radiographic SpA. Thus, we evaluated the association of serum uric acid (SUA) concentration and radiographic SpA. Methods: We made use of data from a cross-sectional study in Chinese Shenzhen Second People’s Hospital from 2016 to 2018, which included 202 SpA patients diagnosed by rheumatologists. This study detected the prevalence of comorbidities and risk factors of SpA patients. Using data from this study, we evaluated the association between radiographic images of SpA and SUA concentration. We compared the SUA concentration between radiographic SpA group and non-radiographic SpA group, with logistic regression models. Stratified and interaction analyses were also performed to further confirm the consistence of the relationship. Multiple imputation was used to deal with missing data.Results: This research studied 202 SpA patients’ data including their SUA, sacroiliac images, and other relevant laboratory data. Elevated SUA concentration was found to be associated independently with the increased risk of radiographic SpA after adjusted for confounders. The risk for developing radiographic SpA increased 13% [adjusted odds ratio (OR) = 1·13, 95% confidence interval (CI):(1·05, 1·22), p=0·0014] for per 10umol/L SUA increased. Stratified analyses, interaction analyses and multiple imputation analyses also confirmed the consistence of the association.Conclusions: Based on this Chinese population cross-sectional study, we identify that elevated SUA concentration is a risk factor for developing radiographic SpA.

Correlation of Glycemic Control Parameters in Non-Diabetic Persons with Cardiovascular Risk Scores - Results from a Cross- Sectional Study

2017 ◽  
Vol 68 (1) ◽  
pp. 108-110
Author(s):  
Gina Botnariu ◽  
Norina Forna ◽  
Alina Popa ◽  
Raluca Popescu ◽  
Alina Onofriescu ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Glycemic Control ◽  
Tolerance Test ◽  
Cross Sectional Study ◽  
Risk Scores ◽  
Oral Glucose ◽  
Cross Sectional ◽  
University Of Edinburgh ◽  
Fasting Glycaemia ◽  
The University

To assess the correlation between main parameters of glycemic control and cardiovascular risk scores in non-diabetic persons. Risk scores were calculated by using the University of Edinburgh Risk Calculator. Risk scores are used to estimate the probability of cardiovascular disease in individuals who have not already developed major atherosclerotic disease. We correlated the results of these scores with the parameters that describes the glycaemic profile: preprandial glicaemia, HbA1c and 1 hour and 2 h post-prandial glycaemia, determined during Oral Glucose Tolerance Test (OGTT).Both fasting glycaemia and HbA1c significantly correlated with cardiovascular risk scores calculated for a period of 10 years. The recorded post-prandial glycaemic values at 1h and 2h after glucose loading didn�t significantly correlate with calculated scores, in the study group. The observed correlations underline the importance of glycaemia in the pathogenesis of cardiovascular diseases.

scholarly journals SARS-CoV-2 seroprevalence and asymptomatic viral carriage in healthcare workers: a cross-sectional study

Thorax ◽  
2020 ◽  
Vol 75 (12) ◽  
pp. 1089-1094 ◽  
Author(s):  
Adrian Shields ◽  
Sian E Faustini ◽  
Marisol Perez-Toledo ◽  
Sian Jossi ◽  
Erin Aldera ◽  
...  
Keyword(s):  
Intensive Care ◽  
Healthcare Workers ◽  
Venous Blood ◽  
Cross Sectional Study ◽  
Nasopharyngeal Swab ◽  
Sectional Study ◽  
University Hospitals ◽  
Cross Sectional ◽  
General Internal ◽  
Increased Risk

ObjectiveTo determine the rates of asymptomatic viral carriage and seroprevalence of SARS-CoV-2 antibodies in healthcare workers.DesignA cross-sectional study of asymptomatic healthcare workers undertaken on 24/25 April 2020.SettingUniversity Hospitals Birmingham NHS Foundation Trust (UHBFT), UK.Participants545 asymptomatic healthcare workers were recruited while at work. Participants were invited to participate via the UHBFT social media. Exclusion criteria included current symptoms consistent with COVID-19. No potential participants were excluded.InterventionParticipants volunteered a nasopharyngeal swab and a venous blood sample that were tested for SARS-CoV-2 RNA and anti-SARS-CoV-2 spike glycoprotein antibodies, respectively. Results were interpreted in the context of prior illnesses and the hospital departments in which participants worked.Main outcome measureProportion of participants demonstrating infection and positive SARS-CoV-2 serology.ResultsThe point prevalence of SARS-CoV-2 viral carriage was 2.4% (n=13/545). The overall seroprevalence of SARS-CoV-2 antibodies was 24.4% (n=126/516). Participants who reported prior symptomatic illness had higher seroprevalence (37.5% vs 17.1%, χ2=21.1034, p<0.0001) and quantitatively greater antibody responses than those who had remained asymptomatic. Seroprevalence was greatest among those working in housekeeping (34.5%), acute medicine (33.3%) and general internal medicine (30.3%), with lower rates observed in participants working in intensive care (14.8%). BAME (Black, Asian and minority ethnic) ethnicity was associated with a significantly increased risk of seropositivity (OR: 1.92, 95% CI 1.14 to 3.23, p=0.01). Working on the intensive care unit was associated with a significantly lower risk of seropositivity compared with working in other areas of the hospital (OR: 0.28, 95% CI 0.09 to 0.78, p=0.02).Conclusions and relevanceWe identify differences in the occupational risk of exposure to SARS-CoV-2 between hospital departments and confirm asymptomatic seroconversion occurs in healthcare workers. Further investigation of these observations is required to inform future infection control and occupational health practices.

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