scholarly journals The Association Between Uric Acid and Symmetric Dimethylarginine Levels in the Patients Undergoing Twice-weekly Hemodialysis

2021 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Aida Lydia ◽  
Yassir Yassir ◽  
Rudy Hidayat ◽  
Suhendro Suwarto
Keyword(s):  
Uric Acid ◽  
Venous Blood ◽  
Tertiary Hospital ◽  
Cross Sectional Study ◽  
Hemodialysis Patients ◽  
Bivariate Analysis ◽  
Symmetric Dimethylarginine ◽  
Cross Sectional ◽  
Increased Risk ◽  
History Of

Background: Uric acid (UA) levels are associated with increased risk of cardiovascular events and mortality in hemodialysis patients. However, there are still conflicting data on the mechanism of increased risks related to uric acid levels. Objectives: This study assessed the association between uric acid levels and symmetric dimethylarginine (SDMA), as a marker of cardiovascular disease, in the subjects undergoing hemodialysis twice weekly. Methods: This was a cross-sectional study conducted in a tertiary hospital in Jakarta, Indonesia. We included all the adults who underwent hemodialysis twice weekly for at least three months in our hospital. Subjects already on uric acid lowering therapy, pregnant or lactating women and those with a history of malignancy were excluded. Uric acid and SDMA levels were measured at the same time in pre-dialysis venous blood samples. Bivariate analysis was performed using the Mann-Whitney U test or one-way ANOVA. Results: A total of 126 subjects were included. The median level of UA was 8.4 mg/dL (IQR: 2.6, min: 4.1, max: 13.6), and 72 subjects (57.14%) had UA levels of 8 mg/dL or higher. The median SDMA level was 535.5 (312.7) mmol/dL (min: 119.7, max: 1895.5). Subjects with UA levels > 8 mg/dL had significantly higher SDMA levels compared to subjects with UA levels < 8 mg/dL (550.1 (IQR: 357.25) vs 491.35 (IQR: 181.1), P: 0.0475). Conclusions: In twice-weekly hemodialysis patients, UA levels above 8 mg/dL were associated with increased SDMA levels.

scholarly journals SARS-CoV-2 seroprevalence and asymptomatic viral carriage in healthcare workers: a cross-sectional study

Thorax ◽  
2020 ◽  
Vol 75 (12) ◽  
pp. 1089-1094 ◽  
Author(s):  
Adrian Shields ◽  
Sian E Faustini ◽  
Marisol Perez-Toledo ◽  
Sian Jossi ◽  
Erin Aldera ◽  
...  
Keyword(s):  
Intensive Care ◽  
Healthcare Workers ◽  
Venous Blood ◽  
Cross Sectional Study ◽  
Nasopharyngeal Swab ◽  
Sectional Study ◽  
University Hospitals ◽  
Cross Sectional ◽  
General Internal ◽  
Increased Risk

ObjectiveTo determine the rates of asymptomatic viral carriage and seroprevalence of SARS-CoV-2 antibodies in healthcare workers.DesignA cross-sectional study of asymptomatic healthcare workers undertaken on 24/25 April 2020.SettingUniversity Hospitals Birmingham NHS Foundation Trust (UHBFT), UK.Participants545 asymptomatic healthcare workers were recruited while at work. Participants were invited to participate via the UHBFT social media. Exclusion criteria included current symptoms consistent with COVID-19. No potential participants were excluded.InterventionParticipants volunteered a nasopharyngeal swab and a venous blood sample that were tested for SARS-CoV-2 RNA and anti-SARS-CoV-2 spike glycoprotein antibodies, respectively. Results were interpreted in the context of prior illnesses and the hospital departments in which participants worked.Main outcome measureProportion of participants demonstrating infection and positive SARS-CoV-2 serology.ResultsThe point prevalence of SARS-CoV-2 viral carriage was 2.4% (n=13/545). The overall seroprevalence of SARS-CoV-2 antibodies was 24.4% (n=126/516). Participants who reported prior symptomatic illness had higher seroprevalence (37.5% vs 17.1%, χ2=21.1034, p<0.0001) and quantitatively greater antibody responses than those who had remained asymptomatic. Seroprevalence was greatest among those working in housekeeping (34.5%), acute medicine (33.3%) and general internal medicine (30.3%), with lower rates observed in participants working in intensive care (14.8%). BAME (Black, Asian and minority ethnic) ethnicity was associated with a significantly increased risk of seropositivity (OR: 1.92, 95% CI 1.14 to 3.23, p=0.01). Working on the intensive care unit was associated with a significantly lower risk of seropositivity compared with working in other areas of the hospital (OR: 0.28, 95% CI 0.09 to 0.78, p=0.02).Conclusions and relevanceWe identify differences in the occupational risk of exposure to SARS-CoV-2 between hospital departments and confirm asymptomatic seroconversion occurs in healthcare workers. Further investigation of these observations is required to inform future infection control and occupational health practices.

scholarly journals Medico-social Profile of Women Experiencing Menopausal Syndrome Attending a Periurban Hospital

2017 ◽  
Vol 35 (4) ◽  
pp. 179-183
Author(s):  
Saria Tasnim ◽  
FH Anamul Hoque ◽  
Summyia Nazmeen
Keyword(s):  
Health Care Services ◽  
Psychological Symptoms ◽  
Family Relationship ◽  
Tertiary Hospital ◽  
Cross Sectional Study ◽  
Menopausal Syndrome ◽  
Cross Sectional ◽  
Care Services ◽  
Nutritional Characteristics ◽  
History Of

Women’s health is a global concern now a days. Studies on issues relating to menopause is lacking Bangladesh and those been conducted mainly focus on physical and psychological symptoms around the time of menopause. This cross sectional study was done to explore the sociomedical context and nutritional characteristics of a group of women approaching menopause A total 106 women aged 45-60 years attending Gynae outpatient department of a tertiary hospital between March- May, 2013 was interviewed using structured questionnaire after obtaining informed written consent. Height and weight was measured using standardized procedure. Data analysed using SPSS. Mean age was 50.3± 5.3 years, about 75.5% were between 45-50 years, 85.1% had more than 2 children and 72.6% had history of Abortion. Mean age at menopause 44.65 ± 6.4 years, range 32-58 yrs. Mean BMI was 25± 4.2 and 43.4% were overweight or Obese. Chronic illness like hypertension and arthritis was present in (15.09%) and diabetes mellitus in 10.3% . The family relationship with children was good in 78.09%, husband was reported caring in 72.3% and 2.8% receive abusive behavior from husband. Only 8.5% were self earning, 24.5% and & 17.9% were dependent on children and husband respectively. With increasing life expectancy and improvements of health care services there is greater chance of survival for a women beyond menopause. Sociocultural and medical characteristics of midlife women is important to explore their specific health needs. Ensuring quality of life for this special group of women will help to better utilize their potential for development of the country.J Bangladesh Coll Phys Surg 2017; 35(4): 179-183

scholarly journals OVARIAN MALIGNANCY

2018 ◽  
Vol 25 (02) ◽  
pp. 237-241
Author(s):  
Shabana Rafiq ◽  
Razia Bibi ◽  
Samina Ashraf
Keyword(s):  
Cross Sectional Study ◽  
Reproductive Age ◽  
Ovarian Malignancy ◽  
Ovarian Mass ◽  
Sectional Study ◽  
Women Of Reproductive Age ◽  
Cross Sectional ◽  
Increased Risk ◽  
History Of ◽  
Study Setting

Objectives: To determine the frequency of ovarian malignancy in women ofreproductive age presenting with ovarian mass and to determine frequency of factors leadingto ovarian malignancy. Study Design: Cross sectional study. Setting: Department of Obstetrics& Gynaecology, Lady Wallington Hospital, Lahore. Period with Dates: From 05.11.11 to26.06.12. Results: The result of our study reveals majority of the patients between 21-30 yearsi.e. 45.88%(n=39), common age was 24.21+3.76 years, 43.53%(n=37) were nulliparous (inmajority), while frequency of ovarian malignancy in women of reproductive age presenting withovarian mass was recorded in 14.11%(n=12) while frequency of factors leading to ovarianmalignancy was 91.67%(n=11) patients were nulliparous while family history of ovarianmalignancy was in 8.33%(n=1) patients. Conclusions: The frequency of ovarian malignancy ishigher among reproductive age females with increased risk of nulliparity.

Evaluating depression and suicidality in tetrabenazine users with Huntington disease

Neurology ◽  
2018 ◽  
Vol 91 (3) ◽  
pp. e202-e207 ◽  
Author(s):  
Jordan L. Schultz ◽  
Annie Killoran ◽  
Peg C. Nopoulos ◽  
Chloe C. Chabal ◽  
David J. Moser ◽  
...  
Keyword(s):  
Suicidal Ideation ◽  
Huntington Disease ◽  
Cross Sectional Study ◽  
Cag Repeat ◽  
Cross Sectional ◽  
Increased Risk ◽  
History Of ◽  
Antidepressant Use ◽  
History Of Depression ◽  
Total Functional Capacity

ObjectiveTo determine whether tetrabenazine (TBZ) use is associated with an increased incidence of depression and/or suicidal ideation.MethodsIn this retrospective cross-sectional study of the Enroll-HD database, we used multiple logistic regression analyses to determine whether TBZ use is associated with an increased incidence of depression and/or suicidal ideation. For both dependent variables (depression and suicidality), separate analyses were conducted on (1) all participants, (2) only participants with a history of depression, and (3) only participants with no history of depression. Adjustments were made for CAG repeat length, total motor score, total functional capacity, Symbol Digit Modalities Test score, sex, disease duration, history of depression (when applicable), antipsychotic use, and antidepressant use.ResultsCompared to participants who were not using TBZ (n = 3,548), TBZ users (n = 543) did not have an increased risk of depression (odds ratio [OR] = 0.78, p = 0.064). Participants taking TBZ actually had a relatively lower risk of suicidality (OR = 0.61, p = 0.043). Among only participants with a history of depression, those using TBZ had a lower incidence of depression (OR = 0.71, p = 0.016) and suicidal ideation (OR = 0.57, p = 0.028) compared to those not using TBZ. Finally, among only participants with no history of depression, TBZ use was not associated with a higher incidence of depression (OR = 1.59, p = 0.18) or suicidality (OR = 1.43, p = 0.66) compared to those who were not using TBZ.ConclusionsTBZ use was not associated with an increased incidence of depression or suicidality. These findings suggest that TBZ may be safe to use in patients with Huntington disease who have a history of depression.

scholarly journals Prevalence and Clinical Features of Atopic Dermatitis in China

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Xin Wang ◽  
Lin-Feng Li ◽  
Da-yu Zhao ◽  
Yi-wei Shen
Keyword(s):  
Atopic Dermatitis ◽  
Bacterial Infection ◽  
Clinical Features ◽  
Population Based ◽  
Cross Sectional Study ◽  
Morbidity Rate ◽  
Cross Sectional ◽  
Increased Risk ◽  
Tertiary Hospitals ◽  
History Of

Background. The epidemiology of atopic dermatitis (AD) in Chinese outpatients is yet to be clarified.Objectives. To investigate population-based prevalence and clinical features of AD in Chinese outpatients.Methods. A multicenter cross-sectional study was conducted in outpatients with eczema or dermatitis from 39 tertiary hospitals in 15 provinces.Results. This study included 682 patients diagnosed with AD, with the mean age of28.8±20.1years and the median course of5.3±6.9years. AD patients had more severe itching (30.4% versus 13.8%,p<0.001) and clinically suspected bacterial infection (21.7% versus 16.1%,p<0.001) than those of other types of dermatitis. Older patients were more susceptible to have a history of flexion dermatitis (p<0.001), bacterial infection (p=0.005), and severe itching (p<0.001). Outpatients with clinically suspected bacterial infection had 3.53-fold increased risk of AD than those without it (p<0.001). The morbidity rate of AD in the (20–25°N) region is 2.86 times higher than that in the (40–45°N) region [OR (95% CI): 0.352 (0.241–0.514),p<0.001].Conclusions. AD is characterized by unique clinical/demographic features. Bacterial infection and latitude region may have an impact on the incidence of AD in China.

scholarly journals Timing of presentation and correlation with computed tomography in pediatric patients with minor head trauma

2018 ◽  
Vol 5 (6) ◽  
pp. 2038
Author(s):  
Karthick Jayapal ◽  
Hassan Adnan Mansour
Keyword(s):  
Computed Tomography ◽  
Head Trauma ◽  
Cross Sectional Study ◽  
Minor Head Trauma ◽  
Cross Sectional ◽  
Increased Risk ◽  
Key Factor ◽  
History Of ◽  
Study Participants ◽  
Type Of Injury

Background: The presentation of minor head trauma warrants immediate and accurate diagnosis for early clinical management among children. Computed Tomography is the gold standard tool for the diagnosis of Traumatic Brain Injury (TBI) among the children. The timing of presentation may have a significant role in predicting the incidence of TBI. This study was done to compare the CT findings among children who presented within and after 24 hours with minor head trauma.Methods: This cross-sectional study was carried out among 992 children between 2-15 years reporting with a history of head injury. All the participants were clinically examined, and relevant history of type of injury and timing of presentation was recorded. CT scan was taken as per PECARN criteria. Data was entered and analysed using SPSS ver 15 software.Results: Majority of the participants belonged to 6-10 years of age (45.2%) and were males (58.5%). About 81.7% of the participants presented within 24 hours. The overall prevalence of TBI among the study participants was 58.6% [55.5-61.6].It was observed that hematoma predominantly presented after 24 hours (74.2%) and majority of the falls presented after 24 hours (92.8%).Patients who presented after 24 hours were at increased risk of presenting as TBI (67.03%) compared to those presenting within 24 hours (56.8%;p<0.05).Conclusions: This study has emphasized the need for including the timing of presentation as a key factor for facilitating early diagnosis and rapid case management of pediatric head trauma.

scholarly journals Predictors of impaired pulmonary function in people living with HIV in an urban African setting

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Sarah E. Van Riel ◽  
Kerstin Klipstein-Grobusch ◽  
Roos E. Barth ◽  
Diederick E. Grobbee ◽  
Charles Feldman ◽  
...  
Keyword(s):  
Lung Function ◽  
Characteristic Curve ◽  
Cross Sectional Study ◽  
Forced Expiratory Volume ◽  
Normal Lung ◽  
People Living With Hiv ◽  
Cross Sectional ◽  
Increased Risk ◽  
Impaired Lung Function ◽  
History Of

Background: Studies have associated HIV with an increased risk of obstructive lung disease (OLD).Objectives: We aimed to identify the predictive factors for impaired lung function in an urban, African, HIV-positive population.Method: A cross-sectional study was performed in Johannesburg, South Africa, from July 2016 to November 2017. A questionnaire was administered and pre- and post-bronchodilator spirometry conducted. The predictors investigated included age, sex, antiretroviral treatment (ART) duration, body mass index, history of tuberculosis (TB) or pneumonia, occupational exposure, environmental exposure, smoking and symptoms of OLD (cough, wheeze, mucus and dyspnoea). Impaired lung function was defined as a forced expiratory volume in 1 second/forced vital capacity (FEV1/FVC) ratio of 0.70, or below the 20th percentile of normal.Results: The 98 ART-naïve participants (mean age = 34.0, standard deviation [s.d.] = 8.2), 85 participants on first-line ART (mean age = 36.9, s.d. = 6.6) and 189 participants on second-line ART (mean age = 43.5, s.d. = 7.9) were predominantly female (65.6%). Of the participants, 64 (17.2%) had impaired lung function and 308 had normal lung function. Linear regression identified age (β = –0.003, P 0.01), male sex (β = –0.016, P = 0.03) and history of TB or pneumonia (β = –0.024, P 0.01) as independent predictors of a lower FEV1/FVC ratio. Following logistic regression, only a history of TB or pneumonia (odds ratio = 2.58, 95% confidence interval = 1.47–4.52) was significantly related to impaired lung function (area under the receiver operating characteristic curve = 0.64).Conclusion: Our data show that a history of TB or pneumonia predicts impaired lung function. In order to improve timely access to spirometry, clinicians should be alert to the possibility of impaired lung function in people with a history of TB or pneumonia.

scholarly journals Patients’ Perception towards General and Pelvic Examination by Male Medical Students: A Cross-sectional Study in a Multi-ethnic Population

2021 ◽  
Vol 20 (4) ◽  
Author(s):  
Valliammai Jayanthi Thirunavuk Arasoo ◽  
Nisha Angela Dominic ◽  
Vanassa Ratnasingam ◽  
Md Inzamum Ul Islam ◽  
Erin Ziyi Lee ◽  
...  
Keyword(s):  
Medical Students ◽  
Tertiary Hospital ◽  
Cross Sectional Study ◽  
Public Health Care ◽  
Male Students ◽  
Pelvic Examination ◽  
Sectional Study ◽  
Health Care Centre ◽  
Cross Sectional ◽  
History Of

Introduction Male medical students globally have difficulty in obtaining consent to perform pelvic examination. We sought to identify independent factors influencing women consenting to male medical students performing general and pelvic examination under supervision. Methods This cross-sectional study conducted at a tertiary hospital and a public health care centre in Johor Bahru, Malaysia recruited 369 women above 18 years old who have had  sexual intercourse before and no prior hysterectomy. A validated self-administered bilingual questionnaire was used to collect data on factors that influence them consenting to male medical students examining them and performing pelvic examination when indicated. Results The respondents were largely below 30 years old (52.9%), Malays (73.4%) and Muslims (75.3%). The consent rates for general and pelvic examination were 27.4% and 18.9%, respectively. Being a Muslim, having an occupation and being introduced by a male medical specialist increased the likelihood of women consenting to general examination. However, a history of being examined by male students decreased the likelihood by 64%. Believing that male doctors should have the skills to treat patients in women's health was the only independent factor that increased the likelihood for women to consent for pelvic examination to be conducted by male medical students.  Conclusion Believing that male doctors should be skilled in treating women positively influences decision to consent. Explaining earnestly to women on how they aid in developing the skills of future doctors should be prioritised. Keywords: patients’ perception; male medical students; pelvic examination

scholarly journals Aetiopathological and demographic profile of diabetic foot: a prospective cross sectional study from a tertiary hospital in South India

2017 ◽  
Vol 4 (4) ◽  
pp. 1305
Author(s):  
Ragesh Kalikottu Valappil ◽  
Sheena Krishnan ◽  
Siddharth Matad ◽  
Shameej Kinakool Vayalipath
Keyword(s):  
Glycemic Control ◽  
Diabetic Foot ◽  
Foot Ulcer ◽  
Tertiary Hospital ◽  
Cross Sectional Study ◽  
Poor Glycemic Control ◽  
Sectional Study ◽  
Cross Sectional ◽  
Female Ratio ◽  
History Of

Background: Diabetes mellitus is a chronic disorder affecting large segment of population and is a major public health problem.Methods: A prospective cross sectional study of 150 patients conducted in the Department of Surgery at Government Medical College, Kozhikode, Kerala, IndiaResults: Maximum numbers of patients were in the age group of 60-69. Male to female ratio is 3.04:1.50% had duration of diabetes <10 years and 50% had duration ≥10. years. 81 (54%) patients had neuropathy, 53 (35.3%) had PVD, 41 (27.3%) had history of prior foot ulcer, 70 (46.7%) had poor glycemic control (RBS >200 mg/dl) at the time of admission and 44 (29.3%) had history of smoking.Conclusions: Most important risk factors for diabetic foot ulcers were neuropathy (54%), poor glycemic control (46.7%) and PVD (35.3%), diabetic foot requires a comprehensive management.

scholarly journals Factors related to pain management adequacy in patients receiving palliative care: data from a tertiary hospital in Indonesia

2020 ◽  
Vol 29 (4) ◽  
pp. 399-402
Author(s):  
Hamzah Shatri ◽  
Ratih Arianita Agung ◽  
Vera Abdullah ◽  
Dina Elita ◽  
Rudi Putranto ◽  
...  
Keyword(s):  
Palliative Care ◽  
Pain Management ◽  
Pain Intensity ◽  
Tertiary Hospital ◽  
Cross Sectional Study ◽  
Bivariate Analysis ◽  
Opioid Use ◽  
Cross Sectional ◽  
Pain Management Index ◽  
Adequate Pain Management

BACKGROUND Adequate pain management must be applied to improve the quality of life, particularly in patients receiving palliative care. Thus, this study aimed to determine the factors related to pain management adequacy in patients receiving palliative care. METHODS This cross-sectional study included all patients sent for consultation to the palliative care team complaining of pain in Cipto Mangunkusumo Hospital, Jakarta, Indonesia from 2016 to 2018. All data such as gender, age, employment status, disease type, primary cancer location, pain intensity, analgesic drug treatment duration, and the presence of anxiety and depression were retrieved from medical records. Pain management adequacy was evaluated using the pain management index. Logistic regression included all variables with p<0.25 related to pain management adequacyin bivariate analysis. RESULTS Out of 175 patients with pain, 85.7% reported having adequate pain management. Pain was more adequately treated in patients with employment (p = 0.001), milder pain intensity (p<0.001), those using opioids (p<0.001), and those who did not experience anxiety (p = 0.05). Factors related to pain management adequacy were opioid use (OR = 3.23, 95% CI = 1.71–6.13) and milder pain (OR = 11.15, 95% CI = 3.89–31.99). CONCLUSIONS Most of the patients received adequate pain management which related to opioid use and milder pain.

Sign in / Sign up

Export Citation Format

Share Document