Snail Soothing and Repairing Cream Improves Skin Hydration after Ablative Fractional CO2 Laser: A Split-Face Randomized Double-Blinded Placebo-Controlled Trial

2021 ◽  
pp. 1-9
Author(s):  
Chinathip Theerawattanawit ◽  
Tiwanun Promvaranon ◽  
Pawinee Rerknimitr ◽  
Pravit Asawanonda ◽  
Nopadon Noppakun ◽  
...  
Keyword(s):  
Carbon Dioxide Laser ◽  
Controlled Trial ◽  
Skin Barrier ◽  
Transepidermal Water Loss ◽  
Skin Hydration ◽  
Clinical Assessments ◽  
Fractional Carbon Dioxide Laser ◽  
Double Blinded ◽  
Antioxidant Effects ◽  
Split Face

<b><i>Background:</i></b> Ablative fractional carbon dioxide laser (AFCO2) resurfacing causes transient skin barrier disruption characterized by decreased skin hydration and increased transepidermal water loss (TEWL). Snail Soothing and Repairing (SSR) cream, containing several glycoproteins with potential antimicrobial and antioxidant effects, may benefit skin hydration promotion after the laser treatment. <b><i>Objective:</i></b> To evaluate the efficacy and safety of SSR cream in skin hydration promotion after AFCO2 resurfacing. <b><i>Method:</i></b> The study was a double-blinded, split-face, placebo-controlled trial in participants aged 18–50 years with atrophic acne scars on both cheeks. After AFCO2 resurfacing, participants applied the product or placebo on either cheek twice daily for 14 days. Corneometry, TEWL, colorimetry, and clinical assessments (edema, erythema, crusting, pruritus, and tightness score) were evaluated at baseline, day 7, and day 14 after AFCO2 resurfacing. <b><i>Results:</i></b> From 22 participants in the study, the SSR cream-treated sides showed significantly higher corneometry levels than placebo-treated sides at day 14 (<i>p</i> = 0.033), while TEWL and colorimetry levels were not different at any study visits. Pruritus and tightness scores of the SSR side were lower, but not significant, than the placebo. Other clinical assessments (edema, erythema, and crusting) showed similar results. No significant adverse events took place. <b><i>Conclusion:</i></b> The SSR cream significantly improved skin hydration, highlighting skin barrier restoration after AFCO2 resurfacing, with a good safety profile.

Evaluation of autologous adipose‐derived stem cells vs. fractional carbon dioxide laser in the treatment of post acne scars: a split‐face study

2019 ◽  
Vol 58 (10) ◽  
pp. 1212-1222 ◽  
Author(s):  
Rania S. Abou Eitta ◽  
Aisha A. Ismail ◽  
Rania A. Abdelmaksoud ◽  
Naser A. Ghezlan ◽  
Radwa A. Mehanna
Keyword(s):  
Carbon Dioxide ◽  
Stem Cells ◽  
Carbon Dioxide Laser ◽  
Adipose Derived Stem Cells ◽  
Acne Scars ◽  
Fractional Carbon Dioxide Laser ◽  
Split Face

scholarly journals Moisturizing effect of a cosmetic formulation containing pequi oil (Caryocar brasiliense) from the Brazilian cerrado biome

2014 ◽  
Vol 50 (1) ◽  
pp. 131-136 ◽  
Author(s):  
Wanessa Costa Silva Faria ◽  
Gabriel Azevedo de Brito Damasceno ◽  
Márcio Ferrari
Keyword(s):  
Stratum Corneum ◽  
Water Content ◽  
Skin Barrier ◽  
Transepidermal Water Loss ◽  
Skin Hydration ◽  
Skin Barrier Function ◽  
Brazilian Cerrado ◽  
Single Application ◽  
Caryocar Brasiliense ◽  
Stratum Corneum Water Content

Caryocar brasiliense, popularly known in Brazil as “pequi”, is a species widely distributed in the Brazilian Cerrado. The seeds are surrounded by a woody endocarp coated with a yellow fleshy mesocarp rich in oil and vitamin A, whose oil has a useful role in the treatment of skin aging and protection of human skin against UV-induced damage and skin hydration. The aim of this study was to evaluate the effect of cosmetic formulations containing pequi oil (Caryocar brasiliense) on skin hydration, after a single application. Hydration effect assessment was performed by applying the formulations under study (Control – no formulation, vehicle, and vehicle + pequi oil) onto forearm skin of 30 human volunteers. Skin capacitance and Transepidermal Water Loss (TEWL) measurements were analyzed before, and at 1, 2 and 3 hours after, a single application. Evaluation results of a single application of the vehicle containing pequi oil showed an increase in stratum corneum water content, indicating a skin moisturizing effect. Results of the evaluation of immediate effects of TEWL demonstrated that the vehicle containing pequi oil significantly increased skin moisture during the 3 h evaluation period. The formulations containing pequi oil showed clinical efficacy, increasing stratum corneum water content and enhancing skin barrier function.

scholarly journals Effects of Venusia Max Lotion on skin hydration and skin barrier in patients with dry skin

2021 ◽  
Vol 1 ◽  
pp. 41
Author(s):  
Monil Yogesh Neena Gala ◽  
Snehal Sameer Muchhala ◽  
Sujeet Narayan Charugulla ◽  
Rahul Rathod ◽  
Amey Mane ◽  
...  
Keyword(s):  
Skin Barrier ◽  
Barrier Properties ◽  
Transepidermal Water Loss ◽  
Control Site ◽  
Skin Hydration ◽  
Animal Origin ◽  
Dry Skin ◽  
Time Points ◽  
Test Product ◽  
Study Test

Objectives: The objectives of the study were to evaluate skin hydration and transepidermal water loss (TEWL), after the application of the test product (Venusia Max Lotion [Paraben, Alcohol, Mineral Oil, and Animal Origin (PAMA)] free). Material and Methods: The study was a single-center, non-randomized, observational study. Test product was compared to control sites after application on volar forearms of women with dry skin. Hydration and TEWL measurements at baseline, after 12 hours, 24 hours and 36 hours of product application were done under the occluded and unoccluded condition. Results: The study was completed with 30 female subjects. Increase in the mean MMSC values was significantly greater on test product site as compared to control site, at all-time points. For TEWL readings over 36 h, when kept occluded and unoccluded, respectively, there were no significant differences in TEWL readings between the test product site and control site at any time points. Conclusion: The test product, Venusia Max Lotion (PAMA free), can be useful in maintaining the skin barrier properties and significantly improving skin hydration in individuals with dry skin or dry skin-related conditions.

scholarly journals The Effect of Conditioned Media of Adipose-Derived Stem Cells on Wound Healing after Ablative Fractional Carbon Dioxide Laser Resurfacing

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Bing-Rong Zhou ◽  
Yang Xu ◽  
Shi-Lei Guo ◽  
Yan Xu ◽  
Ying Wang ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Stem Cells ◽  
Wound Healing ◽  
Skin Color ◽  
Carbon Dioxide Laser ◽  
Transepidermal Water Loss ◽  
Control Group ◽  
Adipose Derived Stem Cells ◽  
Laser Resurfacing ◽  
Fractional Carbon Dioxide Laser

Objective.To evaluate the benefits of conditioned medium of Adipose-derived stem cells (ADSC-CM) on wound healing after fractional carbon dioxide laser resurfacing (FxCR) on human skin.Materials and Methods.Nineteen subjects were treated with FxCR on the bilateral inner arms. ADSC-CM was applied on FxCR site of one randomly selected arm. Transepidermal water loss (TEWL), skin color, and gross-elasticity of FxCR site on both arms were measured. Skin samples were taken by biopsy from three subjects 3 weeks after treatment for histopathological manifestations and mRNA expressions of procollagen types I and III, elastin genes were noted.Results.The index of erythema, melanin, and TEWL of the ADSC-CM-treated skin were significantly lower than those of the control side. The mRNA expression of type III procollagen in ADSC-CM-treated group at 3 weeks posttreatment was 2.6 times of that of the control group.Conclusion.Application of allograft ADSC-CM is an effective method for enhancing wound healing after FxCR, by reducing transient adverse effects such as erythema, hyperpigmentation, and increased TEWL.

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